Case Report

Volume: 6 | Issue: 1 | Published: Jan 01, 1970 | Pages: 11 - 16 | DOI: 10.24911/ejmcr/173-1622061632

A case report of sodium glucose co-transporter 2 inhibitor associated euglycemic diabetic ketoacidosis: a diagnostic challenge


Authors: Andrew Richardson , Claire Vincent


Article Info

Authors

Andrew Richardson

Trainee, Raigmore Hospital, Scotland, UK

Claire Vincent

Acute Medicine Consultant, Raigmore Hospital, Scotland, UK

Publication History

Received: August 06, 2021

Revised: September 02, 2021

Accepted: September 02, 2021

Published: January 01, 1970


Abstract


Background: Type 2 diabetes (T2DM) is becoming more prevalent worldwide and sodium-glucose co-transporter-2 (SGLT2) inhibitors are being increasingly used in its management. However, they have been associated with the serious complication of euglycemic diabetic ketoacidosis (EDKA). Case Presentation: A 51-year-old female on canagliflozin for T2DM presented with a 2-week history of vomiting and abdominal pain. With a blood glucose of 9.0 mmol/l, a diagnosis of diabetic ketoacidosis was at first overlooked and the patient was initially managed for pyelonephritis. However, a diagnosis of EDKA was subsequently reached on day 3 after a blood gas revealed a high anion gap metabolic acidosis with ketones of 3.9 mmol/l. Conclusion: This case demonstrates the diagnostic challenge posed by the atypical presentation of SGLT2 inhibitor-associated EDKA. Furthermore, it underlines the need for patient education concerning stopping these medications during illness and highlights how their association with urinary tract infections may further increase the risk of EDKA.

Keywords: Case report, diabetes, SGLT2 inhibitors, euglycemic diabetic ketoacidosis, medication related complication, green


Pubmed Style

Andrew Richardson, Claire Vincent. A case report of sodium glucose co-transporter 2 inhibitor associated euglycemic diabetic ketoacidosis: a diagnostic challenge. EJMCR. 1970; 01 (January 1970): 11-16. doi:10.24911/ejmcr/173-1622061632

Web Style

Andrew Richardson, Claire Vincent. A case report of sodium glucose co-transporter 2 inhibitor associated euglycemic diabetic ketoacidosis: a diagnostic challenge. https://ejmcr.com/articles/1081 [Access: December 25, 2024]. doi:10.24911/ejmcr/173-1622061632

AMA (American Medical Association) Style

Andrew Richardson, Claire Vincent. A case report of sodium glucose co-transporter 2 inhibitor associated euglycemic diabetic ketoacidosis: a diagnostic challenge. EJMCR. 1970; 01 (January 1970): 11-16. doi:10.24911/ejmcr/173-1622061632

Vancouver/ICMJE Style

Andrew Richardson, Claire Vincent. A case report of sodium glucose co-transporter 2 inhibitor associated euglycemic diabetic ketoacidosis: a diagnostic challenge. EJMCR. (1970), [cited December 25, 2024]; 01 (January 1970): 11-16. doi:10.24911/ejmcr/173-1622061632

Harvard Style

Andrew Richardson, Claire Vincent (1970) A case report of sodium glucose co-transporter 2 inhibitor associated euglycemic diabetic ketoacidosis: a diagnostic challenge. EJMCR, 01 (January 1970): 11-16. doi:10.24911/ejmcr/173-1622061632

Chicago Style

Andrew Richardson, Claire Vincent. "A case report of sodium glucose co-transporter 2 inhibitor associated euglycemic diabetic ketoacidosis: a diagnostic challenge." 01 (1970), 11-16. doi:10.24911/ejmcr/173-1622061632

MLA (The Modern Language Association) Style

Andrew Richardson, Claire Vincent. "A case report of sodium glucose co-transporter 2 inhibitor associated euglycemic diabetic ketoacidosis: a diagnostic challenge." 01.January 1970 (1970), 11-16. Print. doi:10.24911/ejmcr/173-1622061632

APA (American Psychological Association) Style

Andrew Richardson, Claire Vincent (1970) A case report of sodium glucose co-transporter 2 inhibitor associated euglycemic diabetic ketoacidosis: a diagnostic challenge. , 01 (January 1970), 11-16. doi:10.24911/ejmcr/173-1622061632