Case Report
Volume: 4 | Issue: 9 | Published: Oct 13, 2020 | Pages: 301 - 304 | DOI: 10.24911/ejmcr/173-1585218303
False-positive high sensitivity troponin I on Alinity i
Authors: Fatima Zehra Kanani , Adnan Haider Kazmi
Article Info
Authors
Fatima Zehra Kanani
Section of Chemical Pathology, The Indus Hospital, Karachi, Pakistan
Adnan Haider Kazmi
Section of Chemical Pathology, The Indus Hospital, Karachi, Pakistan
Publication History
Received: March 31, 2020
Revised: August 19, 2020
Accepted: September 14, 2020
Published: October 13, 2020
Abstract
Background: High sensitivity troponin I (Hs troponin I) is a precise and sensitive marker of myocardial injury. However, interferences by antibodies are not uncommon in immunoassays. Macrotroponin is one such phenomenon, in which immune complexes are formed between troponin and circulating antibodies, giving rise to false-positive results. Case Presentation: This is a case of a 30-year-old male with elevated high sensitivity troponin I results of 419 ng/l (99th percentile upper reference limit for males is 34.2 ng/l). The test was performed on Abbott Alinity i immunoassay analyzer (Abbott Gmbh & Co. KG, Wiesbaden, Germany). Electrocardiogram, exercise tolerance test, and echocardiogram were all unremarkable. The results of creatinine kinase-myocardial component, troponin T, and conventional troponin I on VITROS ECi Immunodiagnostics System (Ortho-Clinical Diagnostics, Rochester, NY) were within normal limits. Laboratory experiments were carried out to evaluate the case, and the investigations conducted indicated the presence of macrotroponins in the specimen, which demonstrated cross immunoreactivity with the Alinity (Abbott) assay but not with the VITROS (Ortho) assay. Conclusion: Clinicians and laboratorians should be aware of the possible interference by macrotroponin in their assays and should be alerted when there is a discordance between the laboratory and clinical findings.
Keywords: Macrotroponin, cardiac biomarkers, autoantibody, heterophile antibody, immunoassay interferences, case report, green
Pubmed Style
Fatima Zehra Kanani, Adnan Haider Kazmi. False-positive high sensitivity troponin I on Alinity i. EJMCR. 2020; 13 (October 2020): 301-304. doi:10.24911/ejmcr/173-1585218303
Web Style
Fatima Zehra Kanani, Adnan Haider Kazmi. False-positive high sensitivity troponin I on Alinity i. https://ejmcr.com/articles/1396 [Access: December 25, 2024]. doi:10.24911/ejmcr/173-1585218303
AMA (American Medical Association) Style
Fatima Zehra Kanani, Adnan Haider Kazmi. False-positive high sensitivity troponin I on Alinity i. EJMCR. 2020; 13 (October 2020): 301-304. doi:10.24911/ejmcr/173-1585218303
Vancouver/ICMJE Style
Fatima Zehra Kanani, Adnan Haider Kazmi. False-positive high sensitivity troponin I on Alinity i. EJMCR. (2020), [cited December 25, 2024]; 13 (October 2020): 301-304. doi:10.24911/ejmcr/173-1585218303
Harvard Style
Fatima Zehra Kanani, Adnan Haider Kazmi (2020) False-positive high sensitivity troponin I on Alinity i. EJMCR, 13 (October 2020): 301-304. doi:10.24911/ejmcr/173-1585218303
Chicago Style
Fatima Zehra Kanani, Adnan Haider Kazmi. "False-positive high sensitivity troponin I on Alinity i." 13 (2020), 301-304. doi:10.24911/ejmcr/173-1585218303
MLA (The Modern Language Association) Style
Fatima Zehra Kanani, Adnan Haider Kazmi. "False-positive high sensitivity troponin I on Alinity i." 13.October 2020 (2020), 301-304. Print. doi:10.24911/ejmcr/173-1585218303
APA (American Psychological Association) Style
Fatima Zehra Kanani, Adnan Haider Kazmi (2020) False-positive high sensitivity troponin I on Alinity i. , 13 (October 2020), 301-304. doi:10.24911/ejmcr/173-1585218303