Case Report
Volume: 4 | Issue: 9 | Published: Sep 28, 2020 | Pages: 296 - 300 | DOI: 10.24911/ejmcr/173-1581872222
An atypical case of AA amyloidosis and its association with pulmonary silicosis
Authors: Filipa Guimarases , Miguel Borges Silva , Joao Correia-Pinto , Ana Branco , Antonio Furtado , Fatima Magalhaes , Jose Vasco Barreto , Raquel Calisto , Nidia Pereira
Article Info
Authors
Filipa Guimarases
Internal Medicine Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal
Miguel Borges Silva
Internal Medicine Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal
Joao Correia-Pinto
Pathologic Anatomy Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal
Ana Branco
Nephrology Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal
Antonio Furtado
Internal Medicine Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal
Fatima Magalhaes
Pathologic Anatomy Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal
Jose Vasco Barreto
Internal Medicine Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal
Raquel Calisto
Internal Medicine Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal
Nidia Pereira
Internal Medicine Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal
Publication History
Received: February 16, 2020
Revised: June 24, 2020
Accepted: July 10, 2020
Published: September 28, 2020
Abstract
Background: Amyloid fibrils are protein polymers. Functional amyloids play a beneficial role in a variety of physiologic processes. Amyloidosis results from the accumulation of pathogenic amyloids in a variety of tissues. Case Presentation: The authors present a case of a 60-year-old male with a pseudotumoral silicosis, a history of intermittent fever, and renal insufficiency with intermittent proteinuria (maximum of 3 g/dl). The diagnosis of amyloidosis was made from multiple biopsies. During the investigation, it was never possible to characterize the subtype of amyloidosis [the patient had findings either in favor of AL amyloidosis and AA amyloidosis (AA)]. A definite diagnosis was only obtained from an autopsy, and AA was found to be the subtype. Conclusion: At the time of this publication and to the best of authorsÂ’ knowledge, AA has never been described to be associated with pseudotumoral form of pulmonary silicosis. We believe that an inflammatory response associated with pulmonary silicosis was the trigger to the development of AA.
Keywords: Amyloidosis AA, amyloidosis AL, systemic amyloidosis, pseudotumoral silicosis, green
Pubmed Style
Filipa Guimarases, Miguel Borges Silva, Joao Correia-Pinto, Ana Branco, Antonio Furtado, Fatima Magalhaes, Jose Vasco Barreto, Raquel Calisto, Nidia Pereira. An atypical case of AA amyloidosis and its association with pulmonary silicosis. EJMCR. 2020; 28 (September 2020): 296-300. doi:10.24911/ejmcr/173-1581872222
Web Style
Filipa Guimarases, Miguel Borges Silva, Joao Correia-Pinto, Ana Branco, Antonio Furtado, Fatima Magalhaes, Jose Vasco Barreto, Raquel Calisto, Nidia Pereira. An atypical case of AA amyloidosis and its association with pulmonary silicosis. https://ejmcr.com/articles/1395 [Access: December 25, 2024]. doi:10.24911/ejmcr/173-1581872222
AMA (American Medical Association) Style
Filipa Guimarases, Miguel Borges Silva, Joao Correia-Pinto, Ana Branco, Antonio Furtado, Fatima Magalhaes, Jose Vasco Barreto, Raquel Calisto, Nidia Pereira. An atypical case of AA amyloidosis and its association with pulmonary silicosis. EJMCR. 2020; 28 (September 2020): 296-300. doi:10.24911/ejmcr/173-1581872222
Vancouver/ICMJE Style
Filipa Guimarases, Miguel Borges Silva, Joao Correia-Pinto, Ana Branco, Antonio Furtado, Fatima Magalhaes, Jose Vasco Barreto, Raquel Calisto, Nidia Pereira. An atypical case of AA amyloidosis and its association with pulmonary silicosis. EJMCR. (2020), [cited December 25, 2024]; 28 (September 2020): 296-300. doi:10.24911/ejmcr/173-1581872222
Harvard Style
Filipa Guimarases, Miguel Borges Silva, Joao Correia-Pinto, Ana Branco, Antonio Furtado, Fatima Magalhaes, Jose Vasco Barreto, Raquel Calisto, Nidia Pereira (2020) An atypical case of AA amyloidosis and its association with pulmonary silicosis. EJMCR, 28 (September 2020): 296-300. doi:10.24911/ejmcr/173-1581872222
Chicago Style
Filipa Guimarases, Miguel Borges Silva, Joao Correia-Pinto, Ana Branco, Antonio Furtado, Fatima Magalhaes, Jose Vasco Barreto, Raquel Calisto, Nidia Pereira. "An atypical case of AA amyloidosis and its association with pulmonary silicosis." 28 (2020), 296-300. doi:10.24911/ejmcr/173-1581872222
MLA (The Modern Language Association) Style
Filipa Guimarases, Miguel Borges Silva, Joao Correia-Pinto, Ana Branco, Antonio Furtado, Fatima Magalhaes, Jose Vasco Barreto, Raquel Calisto, Nidia Pereira. "An atypical case of AA amyloidosis and its association with pulmonary silicosis." 28.September 2020 (2020), 296-300. Print. doi:10.24911/ejmcr/173-1581872222
APA (American Psychological Association) Style
Filipa Guimarases, Miguel Borges Silva, Joao Correia-Pinto, Ana Branco, Antonio Furtado, Fatima Magalhaes, Jose Vasco Barreto, Raquel Calisto, Nidia Pereira (2020) An atypical case of AA amyloidosis and its association with pulmonary silicosis. , 28 (September 2020), 296-300. doi:10.24911/ejmcr/173-1581872222