Case Report
Volume: 4 | Issue: 1 | Published: Jan 01, 1970 | Pages: 39 - 42 | DOI: 10.24911/ejmcr/173-1564156095
Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome
Authors: Arnab Ghosh , Manish Bhartiya , Salil Gupta , Shashindran VK , Puneet Saxena
Article Info
Authors
Arnab Ghosh
Assistant Professor, Armed Forces Medical College, Pune, India
Manish Bhartiya
Senior Resident (DM), Neurology, All India Institute of Medical Sciences, New Delhi, India
Salil Gupta
Professor & HoD (Medicine & Neurology), Army Hospital (R&R), New Delhi, India
Shashindran VK
Former Professor & HoD (Medicine), Armed Forces Medical College, Pune, India
Puneet Saxena
Associate Professor, Respiratory & Critical Care Medicine CH (WC), Chandimandir, India
Publication History
Received: July 27, 2019
Accepted: December 10, 2019
Published: January 01, 1970
Abstract
Background: Klinefelter-syndrome (KS) is recognized as 47, XXY or XXY, two or more X chromosome in males giving rise to a set of clinical signs and symptoms. These individuals are predisposed to certain malignancies. The association of Hodgkinlymphoma (HL) with KS is very rare and reported only in a single case in literature. Moreover, it is extremely rare to have Chronic- Demyelinating-Inflammatory-Polyneuropathy (CIDP) as initial presentation of HL. The association of CIDP in HL in a case of Klinefelter-syndrome has never reported together. Case Presentation: We report a case of 47-year old Indian male who presented with CIDP and was eventually diagnosed with Nodular sclerosis variant of HL. Karyotyping revealed KS. Institution of treatment of HL improved his neurological symptoms. However, administration of androgens was deferred till the completion of chemotherapy. Unfortunately, he could not tolerate Chemotherapy and died of Renal Failure during the fourth cycle. Conclusion: This case report depicts an extremely rare combination of CIDP, HL with KS. It also signifies that all CIDP cases should be evaluated for occult malignancy and if malignancy is found patient should undergo karyotyping for under-diagnosed chromosomal abnormalities such as KS as in this case.
Keywords: Case report, Hodgkin Lymphoma, CIDP, Klinefelter syndrome, para-neoplastic syndrome, green
Pubmed Style
Arnab Ghosh, Manish Bhartiya, Salil Gupta, Shashindran VK, Puneet Saxena. Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome. EJMCR. 1970; 01 (January 1970): 39-42. doi:10.24911/ejmcr/173-1564156095
Web Style
Arnab Ghosh, Manish Bhartiya, Salil Gupta, Shashindran VK, Puneet Saxena. Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome. https://ejmcr.com/articles/1469 [Access: December 25, 2024]. doi:10.24911/ejmcr/173-1564156095
AMA (American Medical Association) Style
Arnab Ghosh, Manish Bhartiya, Salil Gupta, Shashindran VK, Puneet Saxena. Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome. EJMCR. 1970; 01 (January 1970): 39-42. doi:10.24911/ejmcr/173-1564156095
Vancouver/ICMJE Style
Arnab Ghosh, Manish Bhartiya, Salil Gupta, Shashindran VK, Puneet Saxena. Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome. EJMCR. (1970), [cited December 25, 2024]; 01 (January 1970): 39-42. doi:10.24911/ejmcr/173-1564156095
Harvard Style
Arnab Ghosh, Manish Bhartiya, Salil Gupta, Shashindran VK, Puneet Saxena (1970) Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome. EJMCR, 01 (January 1970): 39-42. doi:10.24911/ejmcr/173-1564156095
Chicago Style
Arnab Ghosh, Manish Bhartiya, Salil Gupta, Shashindran VK, Puneet Saxena. "Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome." 01 (1970), 39-42. doi:10.24911/ejmcr/173-1564156095
MLA (The Modern Language Association) Style
Arnab Ghosh, Manish Bhartiya, Salil Gupta, Shashindran VK, Puneet Saxena. "Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome." 01.January 1970 (1970), 39-42. Print. doi:10.24911/ejmcr/173-1564156095
APA (American Psychological Association) Style
Arnab Ghosh, Manish Bhartiya, Salil Gupta, Shashindran VK, Puneet Saxena (1970) Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome. , 01 (January 1970), 39-42. doi:10.24911/ejmcr/173-1564156095