Year 2024, Volume 8 - Issue 3

Background: Anti-Ma2 antibody associated paraneoplastic syndrome (PNS) usually presents as limbic encephalitis in the context of testicular tumors. We report a rare case of anti-Ma2 positive PNS with deviation from the classic scenario, thus expanding the phenotype of anti-ma2 associated PNS. Case presentation: This is a 53-year-old male who presented with what was later diagnosed as anti-Ma2 antibody positive cerebellar ataxia. Further workup revealed retroperitoneal lymphadenopathy which, using biopsy, was identified as metastatic clear cell renal cell carcinoma (RCC). However, imaging did not reveal a primary renal lesion. Conclusion: Physicians should be aware of non-classic presentations of paraneoplastic syndromes, especially given that they commonly precede and point towards an underlying, many times undiagnosed, malignancy.

Background: Hepatocellular carcinoma (HCC) is the most prevalent primary hepatic neoplasm, with approximately 50% of cases eventually developing metastasis. HCC metastasis to the pelvis is exceedingly rare due to the significant anatomical distance and intricate metastatic pathways involved. Case presentation: In this case report, we present a 60-year-old male with HCC metastasis to the pelvis that had infiltrated the rectum. Initially, we suspected the pelvic mass to be a GIST, but histopathological and immunohistochemical examinations revealed it to be HCC metastasis. The dissemination of the tumor was suspected to have occurred through peritoneal implantation following an RFA procedure that the patient had undergone ten months prior. A resection surgery of the sigmoid colon up to the tumor-free mid-rectum was performed. The patient is currently stable and undergoing routine outpatient care, now in the third-month post-surgery. Conclusion: This case report unveils a rare HCC metastasis to the pelvis with rectal infiltration. We conclude that in HCC patients presenting with obstructive symptoms, suspicion of metastasis to the pelvis should be considered, especially in patients who have undergone an RFA procedure. Limited diagnostic support from CT scans and colonoscopy made establishing a definitive diagnosis before surgery challenging. However, patients can attain a favorable prognosis with effective surgical intervention, underscoring the importance of prompt and effective treatment in such cases.

Introduction: Knee pain is one of the most frequent musculoskeletal symptoms in young physically active males. In some cases, it is very painful, can be hard to treat, and often lead to heterotopic ossification of the patellar tendon. To our knowledge, there are no reported cases of remission of ossification after clinical intervention. Case presentation: A 13-year-old Swedish boy with a 3-year anamnesis of severe Osgood-Schlatter with significant ossification of the patellar tendon at the point of tuberositas tibiae, was treated with injections of Liquid Platelet-Rich Fibrin (C-PRF) and Heat-Coagulated Albumin Gel (ALB-PRF) using a horizontal centrifuge system. He recovered and presented a near complete remission of ossification of the patellar tendon two months after treatment and could return to sport after a 3-year break. Conclusion: This case raises the hypothesis that Liquid Platelet-Rich Fibrin and Heat-Coagulated Albumin Gel may be an effective intervention in the treatment of Osgood-Schlatter disease. Further research is required to test this theory.

Background: Zoonoses are infectious diseases, transmittable from vertebrate animals to humans. Hemorrhagic fevers are acute zoonotic diseases that can cause mild to life-threatening illnesses characterized by fever and bleeding disorders, while Brucellosis, also an infectious zoonotic disease, typically presents with high fever, muscle and joint pain, and malaise. Case Presentation: This case report discusses a 33-year-old male patient who presented with a febrile illness, accompanied by bleeding from various orifices, mimicking hemorrhagic fever, which after investigation turned out to be an unusual presentation of Brucellosis. Conclusion: This case emphasizes the importance of considering a broad differential diagnosis in patients with fever and hemorrhagic manifestations, not only in or near regions where Brucellosis is endemic, but also due to increasing international travel and globalization, also in regions where it is not.

Background: This case report delves into the intricate interplay between medical and psychiatric domains through the detailed analysis of a 41-year-old female patient presenting with a myriad of symptoms, including decreased level of consciousness, urinary tract infection (UTI), and subsequent catatonia secondary to depression with psychotic features. Case presentation: The collaborative involvement of Internal Medicine, Neurology, Infectious Disease, and Adult Mental Health specialists underscores the necessity of a multidisciplinary approach. The temporal evolution of the patient's condition, coupled with the sequential adjustments in treatment strategies, provides insights into the nuanced manifestations of overlapping medical and psychiatric conditions. Conclusion: This report aims to highlight the intricate diagnostic process, treatment challenges, and the collaborative efforts required for the successful management of this rare and multifaceted