Background: Glomus tumors are benign and rare vascular tumors, with an incidence of less than 2% in relation to all soft tissue tumors. About 75% occur in hand, especially in the nail bed, even though these tumors may also occur in atypical locations. They are characterized by a triad composed of pain, cold intolerance, and point tenderness. Case Presentation: We present a clinical case of a male patient with 67 years old with a painful lesion on the subcutaneous tissue of the knee with 5 years of evolution. The pain exacerbated with the cold. He underwent surgical excision with pain resolution, and no recurrence or metastasis was found at 30-month follow-up. Conclusion: The rapid diagnosis of glomus tumors is important to avoid treatment delays leading to chronic pain. It is important to consider glomus tumors in the differential diagnosis of subcutaneous lesions.

Keywords: Glomus tumor, glomangioma, atypical location, knee, oncology, case report