EJMCR. 2020; 4(9): 296-300

An atypical case of AA amyloidosis and its association with pulmonary silicosis

Authors: Filipa Guimarases, Miguel Borges Silva, Joao Correia-Pinto, Ana Branco, Antonio Furtado, Fatima Magalhaes, Jose Vasco Barreto, Raquel Calisto, Nidia Pereira.

ABSTRACT

Background: Amyloid fibrils are protein polymers. Functional amyloids play a beneficial role in a variety of physiologic processes. Amyloidosis results from the accumulation of pathogenic amyloids in a variety of tissues. Case Presentation: The authors present a case of a 60-year-old male with a pseudotumoral silicosis, a history of intermittent fever, and renal insufficiency with intermittent proteinuria (maximum of 3 g/dl). The diagnosis of amyloidosis was made from multiple biopsies. During the investigation, it was never possible to characterize the subtype of amyloidosis [the patient had findings either in favor of AL amyloidosis and AA amyloidosis (AA)]. A definite diagnosis was only obtained from an autopsy, and AA was found to be the subtype. Conclusion: At the time of this publication and to the best of authors’ knowledge, AA has never been described to be associated with pseudotumoral form of pulmonary silicosis. We believe that an inflammatory response associated with pulmonary silicosis was the trigger to the development of AA.

Keywords:
Amyloidosis AA, amyloidosis AL, systemic amyloidosis, pseudotumoral silicosis


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An atypical case of AA amyloidosis and its association with pulmonary silicosis


Authors
Filipa Guimarases
Internal Medicine Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal
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Miguel Borges Silva
Internal Medicine Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal
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Joao Correia-Pinto
Pathologic Anatomy Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal
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Ana Branco
Nephrology Department, Hospital Pedro Hispano, Unidade Local de Saúde de Matosinhos, Porto, Portugal
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Antonio Furtado
Internal Medicine Department, Hospital Pedro Hispano, Unidade Local de Saúde de Matosinhos, Porto, Portugal
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Fatima Magalhaes
Pathologic Anatomy Department, Hospital Pedro Hispano, Unidade Local de Saúde de Matosinhos, Porto, Portugal
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Jose Vasco Barreto
Internal Medicine Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal
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Raquel Calisto
Internal Medicine Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal
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Nidia Pereira
Internal Medicine Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal
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Correspondence to:
. Filipa Guimarães, Internal Medicine Department, Hospital Pedro Hispano, Unidade Local de Saude de Matosinhos, Porto, Portugal.; lipaguima@gmail.com

Publication history
Received 16 Feb 2020
Revised 24 Jun 2020
Accepted 10 Jul 2020
Published online 28 Sep 2020
Published in print 17 Oct 2020

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Pubmed Style

Guimarases F, Silva MB, Correia-Pinto J, Branco A, Furtado A, Magalhaes F, Barreto JV, Calisto R, Pereira N. An atypical case of AA amyloidosis and its association with pulmonary silicosis. EJMCR. 2020; 4(9): 296-300. doi:10.24911/ejmcr/173-1581872222


Web Style

Guimarases F, Silva MB, Correia-Pinto J, Branco A, Furtado A, Magalhaes F, Barreto JV, Calisto R, Pereira N. An atypical case of AA amyloidosis and its association with pulmonary silicosis. https://www.ejmcr.com/?mno=87396 [Access: October 23, 2020]. doi:10.24911/ejmcr/173-1581872222


AMA (American Medical Association) Style

Guimarases F, Silva MB, Correia-Pinto J, Branco A, Furtado A, Magalhaes F, Barreto JV, Calisto R, Pereira N. An atypical case of AA amyloidosis and its association with pulmonary silicosis. EJMCR. 2020; 4(9): 296-300. doi:10.24911/ejmcr/173-1581872222


Vancouver/ICMJE Style

Guimarases F, Silva MB, Correia-Pinto J, Branco A, Furtado A, Magalhaes F, Barreto JV, Calisto R, Pereira N. An atypical case of AA amyloidosis and its association with pulmonary silicosis. EJMCR. (2020), [cited October 23, 2020]; 4(9): 296-300. doi:10.24911/ejmcr/173-1581872222


Harvard Style

Guimarases, F., Silva, . M. B., Correia-Pinto, . J., Branco, . A., Furtado, . A., Magalhaes, . F., Barreto, . J. V., Calisto, . R. & Pereira, . N. (2020) An atypical case of AA amyloidosis and its association with pulmonary silicosis. EJMCR, 4 (9), 296-300. doi:10.24911/ejmcr/173-1581872222


Turabian Style

Guimarases, Filipa, Miguel Borges Silva, Joao Correia-Pinto, Ana Branco, Antonio Furtado, Fatima Magalhaes, Jose Vasco Barreto, Raquel Calisto, and Nidia Pereira. 2020. An atypical case of AA amyloidosis and its association with pulmonary silicosis. European Journal of Medical Case Reports, 4 (9), 296-300. doi:10.24911/ejmcr/173-1581872222


Chicago Style

Guimarases, Filipa, Miguel Borges Silva, Joao Correia-Pinto, Ana Branco, Antonio Furtado, Fatima Magalhaes, Jose Vasco Barreto, Raquel Calisto, and Nidia Pereira. "An atypical case of AA amyloidosis and its association with pulmonary silicosis." European Journal of Medical Case Reports 4 (2020), 296-300. doi:10.24911/ejmcr/173-1581872222


MLA (The Modern Language Association) Style

Guimarases, Filipa, Miguel Borges Silva, Joao Correia-Pinto, Ana Branco, Antonio Furtado, Fatima Magalhaes, Jose Vasco Barreto, Raquel Calisto, and Nidia Pereira. "An atypical case of AA amyloidosis and its association with pulmonary silicosis." European Journal of Medical Case Reports 4.9 (2020), 296-300. Print. doi:10.24911/ejmcr/173-1581872222


APA (American Psychological Association) Style

Guimarases, F., Silva, . M. B., Correia-Pinto, . J., Branco, . A., Furtado, . A., Magalhaes, . F., Barreto, . J. V., Calisto, . R. & Pereira, . N. (2020) An atypical case of AA amyloidosis and its association with pulmonary silicosis. European Journal of Medical Case Reports, 4 (9), 296-300. doi:10.24911/ejmcr/173-1581872222


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