EJMCR. 2020; 4(5): 157-160

A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?

Authors: Andreas Eleftheriou, Martin Nilsson, Fredrik Lundin.

ABSTRACT

Background: Idiopathic normal pressure hydrocephalus (iNPH) is usually regarded as a disease characterized by gait and balance disturbance, cognitive dysfunction, and urinary symptoms. The pathophysiology of iNPH is still unknown, but the increased number of familial cases raises the suspicion of a genetic component. The C9ORF72 expansion is known to cause frontotemporal lobar degeneration and ALS, and its prevalence is found among Finnish iNPH patients. Case Presentation: We report an interesting case of a patient with possible iNPH who also developed ALS. Conclusion: Our case raises the theory of coexistence of gene-induced etiology. Key Message: Our case also raises the question of a genetic link between iNPH and ALS.

Keywords:
Idiopathic normal pressure hydrocephalus, familial, C9ORF72 expansion, ALS


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A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?


Authors
Andreas Eleftheriou
Department of Neurology and Department of Biomedical and Clinical Sciences, Division of Neurobiology, Linköping University, Linköping, Sweden
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Martin Nilsson
Department of Neurosurgery in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
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Fredrik Lundin
Department of Neurology and Department of Biomedical and Clinical Sciences, Division of Neurobiology, Linköping University, Linköping, Sweden
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Correspondence to:
. Andreas Eleftheriou, Department of Neurology and Department of Biomedical and Clinical Sciences, Division of Neurobiology, Linköping University, Linköping, Sweden.; andelef2002@yahoo.gr

Publication history
Received 07 Oct 2019
Revised 19 Apr 2020
Accepted 02 May 2020
Published online 26 May 2020
Published in print 16 Jun 2020

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Pubmed Style

Eleftheriou A, Nilsson M, Lundin F. A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?. EJMCR. 2020; 4(5): 157-160. doi:10.24911/ejmcr/173-1570436579


Web Style

Eleftheriou A, Nilsson M, Lundin F. A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?. https://www.ejmcr.com/?mno=68623 [Access: July 11, 2020]. doi:10.24911/ejmcr/173-1570436579


AMA (American Medical Association) Style

Eleftheriou A, Nilsson M, Lundin F. A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?. EJMCR. 2020; 4(5): 157-160. doi:10.24911/ejmcr/173-1570436579


Vancouver/ICMJE Style

Eleftheriou A, Nilsson M, Lundin F. A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?. EJMCR. (2020), [cited July 11, 2020]; 4(5): 157-160. doi:10.24911/ejmcr/173-1570436579


Harvard Style

Eleftheriou, A., Nilsson, . M. & Lundin, . F. (2020) A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?. EJMCR, 4 (5), 157-160. doi:10.24911/ejmcr/173-1570436579


Turabian Style

Eleftheriou, Andreas, Martin Nilsson, and Fredrik Lundin. 2020. A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?. European Journal of Medical Case Reports, 4 (5), 157-160. doi:10.24911/ejmcr/173-1570436579


Chicago Style

Eleftheriou, Andreas, Martin Nilsson, and Fredrik Lundin. "A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?." European Journal of Medical Case Reports 4 (2020), 157-160. doi:10.24911/ejmcr/173-1570436579


MLA (The Modern Language Association) Style

Eleftheriou, Andreas, Martin Nilsson, and Fredrik Lundin. "A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?." European Journal of Medical Case Reports 4.5 (2020), 157-160. Print. doi:10.24911/ejmcr/173-1570436579


APA (American Psychological Association) Style

Eleftheriou, A., Nilsson, . M. & Lundin, . F. (2020) A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?. European Journal of Medical Case Reports, 4 (5), 157-160. doi:10.24911/ejmcr/173-1570436579


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