EJMCR. 2020; 4(1): 39-42

Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome

Authors: Arnab Ghosh, Manish Bhartiya, Salil Gupta, Shashindran VK, Puneet Saxena.

ABSTRACT

Background: Klinefelter-syndrome (KS) is recognized as 47, XXY or XXY, two or more X chromosome in males giving rise to a set of clinical signs and symptoms. These individuals are predisposed to certain malignancies. The association of Hodgkinlymphoma (HL) with KS is very rare and reported only in a single case in literature. Moreover, it is extremely rare to have Chronic- Demyelinating-Inflammatory-Polyneuropathy (CIDP) as initial presentation of HL. The association of CIDP in HL in a case of Klinefelter-syndrome has never reported together. Case Presentation: We report a case of 47-year old Indian male who presented with CIDP and was eventually diagnosed with Nodular sclerosis variant of HL. Karyotyping revealed KS. Institution of treatment of HL improved his neurological symptoms. However, administration of androgens was deferred till the completion of chemotherapy. Unfortunately, he could not tolerate Chemotherapy and died of Renal Failure during the fourth cycle. Conclusion: This case report depicts an extremely rare combination of CIDP, HL with KS. It also signifies that all CIDP cases should be evaluated for occult malignancy and if malignancy is found patient should undergo karyotyping for under-diagnosed chromosomal abnormalities such as KS as in this case.

Keywords:
Case report, Hodgkin Lymphoma, CIDP, Klinefelter syndrome, para-neoplastic syndrome


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Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome


Authors
Arnab Ghosh
Assistant Professor, Armed Forces Medical College, Pune, India
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Manish Bhartiya
Senior Resident (DM), Neurology, All India Institute of Medical Sciences, New Delhi, India
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Salil Gupta
Professor & HoD (Medicine & Neurology), Army Hospital (R&R), New Delhi, India
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Shashindran VK
Former Professor & HoD (Medicine), Armed Forces Medical College, Pune, India
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Puneet Saxena
Associate Professor, Respiratory & Critical Care Medicine CH (WC), Chandimandir, India
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Correspondence to:
. Arnab Ghosh, Dept of Medicine, Armed Forces Medical College, India; afmc.arnab@gmail.com

Publication history
Received 27 Jul 2019
Accepted 10 Dec 2019
Published in print 12 Feb 2020

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Pubmed Style

Ghosh A, Bhartiya M, Gupta S, VK S, Saxena P. Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome. EJMCR. 2020; 4(1): 39-42. doi:10.24911/ejmcr/173-1564156095


Web Style

Ghosh A, Bhartiya M, Gupta S, VK S, Saxena P. Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome. https://www.ejmcr.com/?mno=58715 [Access: February 22, 2020]. doi:10.24911/ejmcr/173-1564156095


AMA (American Medical Association) Style

Ghosh A, Bhartiya M, Gupta S, VK S, Saxena P. Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome. EJMCR. 2020; 4(1): 39-42. doi:10.24911/ejmcr/173-1564156095


Vancouver/ICMJE Style

Ghosh A, Bhartiya M, Gupta S, VK S, Saxena P. Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome. EJMCR. (2020), [cited February 22, 2020]; 4(1): 39-42. doi:10.24911/ejmcr/173-1564156095


Harvard Style

Ghosh, A., Bhartiya, . M., Gupta, . S., VK, . S. & Saxena, . P. (2020) Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome. EJMCR, 4 (1), 39-42. doi:10.24911/ejmcr/173-1564156095


Turabian Style

Ghosh, Arnab, Manish Bhartiya, Salil Gupta, Shashindran VK, and Puneet Saxena. 2020. Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome. European Journal of Medical Case Reports, 4 (1), 39-42. doi:10.24911/ejmcr/173-1564156095


Chicago Style

Ghosh, Arnab, Manish Bhartiya, Salil Gupta, Shashindran VK, and Puneet Saxena. "Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome." European Journal of Medical Case Reports 4 (2020), 39-42. doi:10.24911/ejmcr/173-1564156095


MLA (The Modern Language Association) Style

Ghosh, Arnab, Manish Bhartiya, Salil Gupta, Shashindran VK, and Puneet Saxena. "Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome." European Journal of Medical Case Reports 4.1 (2020), 39-42. Print. doi:10.24911/ejmcr/173-1564156095


APA (American Psychological Association) Style

Ghosh, A., Bhartiya, . M., Gupta, . S., VK, . S. & Saxena, . P. (2020) Hodgkin Lymphoma presenting as a complex paraneoplastic neurological syndrome in an eventually diagnosed case of Klinefelter Syndrome. European Journal of Medical Case Reports, 4 (1), 39-42. doi:10.24911/ejmcr/173-1564156095


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