EJMCR. 2020; 4(2): 65-69

POEMS syndrome: atypical presentation and therapeutic consideration

Authors: Ayman S. Abukamar, Majdi M. Abu-Awida, Saeed M. Abughazaleh, Ahmad R. Abdallah, Hamza M. Al-Zghool.

ABSTRACT

Background: Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare plasma cell dyscrasia, which could be presented as treatment-resistant polyneuropathy before the emergence of other systemic complications. Case Presentation: A 43-year-old male patient presented with progressive lower limb weakness and difficulty in walking, in addition to erectile dysfunction. After the diagnosis of POEMS syndrome, the patient was treated according to the standardized chemotherapeutic regimen for multiple myeloma that includes lenalidomide, without considering the increased risk of thromboembolic complications given that the patient had decreased ambulation due to his polyneuropathy and polycythemia. This warrants a better treatment regimen for these patients to eliminate any possible episode of thromboembolic complications, which might become fatal in the future. Conclusion: Although rare, it was recommended that deep vein thrombosis risk and its link to the proper treatment plan in patients with POEMS syndrome should be studied further.

Keywords:
Case report, POEMS, polyneuropathy, thromboembolic, polycythemia, lenalidomide


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POEMS syndrome: atypical presentation and therapeutic consideration


Authors
Ayman S Abukamar
Hematology and Oncology Department, Royal Medical Services of Jordanian Army (RMS), Amman, Jordan
PubMed articlesGoogle scholar articles

Majdi M Abu-Awida
Neurology Department, Royal Medical Services of Jordanian Army (RMS), Amman, Jordan
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Saeed M Abughazaleh
Student at Medical School, Hashemite University, Jerash, Jordan
PubMed articlesGoogle scholar articles

Ahmad R Abdallah
Internship in University of Jordan Hospital, Amman, Jordan
PubMed articlesGoogle scholar articles

Hamza M Al-Zghool
Student at Medical School, Hashemite University, Jerash, Jordan
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Correspondence to:
. Saeed M. Abughazaleh, Student at Medical School, Hashemite University, Jerash, Jordan.; saeedgazaleh1996@gmail.com

Publication history
Received 16 Jun 2019
Revised 05 Feb 2020
Accepted 08 Feb 2020
Published online 29 Feb 2020
Published in print 12 Mar 2020

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Pubmed Style

Abukamar AS, Abu-Awida MM, Abughazaleh SM, Abdallah AR, Al-Zghool HM. POEMS syndrome: atypical presentation and therapeutic consideration. EJMCR. 2020; 4(2): 65-69. doi:10.24911/ejmcr/173-1560698497


Web Style

Abukamar AS, Abu-Awida MM, Abughazaleh SM, Abdallah AR, Al-Zghool HM. POEMS syndrome: atypical presentation and therapeutic consideration. https://www.ejmcr.com/?mno=53023 [Access: March 29, 2020]. doi:10.24911/ejmcr/173-1560698497


AMA (American Medical Association) Style

Abukamar AS, Abu-Awida MM, Abughazaleh SM, Abdallah AR, Al-Zghool HM. POEMS syndrome: atypical presentation and therapeutic consideration. EJMCR. 2020; 4(2): 65-69. doi:10.24911/ejmcr/173-1560698497


Vancouver/ICMJE Style

Abukamar AS, Abu-Awida MM, Abughazaleh SM, Abdallah AR, Al-Zghool HM. POEMS syndrome: atypical presentation and therapeutic consideration. EJMCR. (2020), [cited March 29, 2020]; 4(2): 65-69. doi:10.24911/ejmcr/173-1560698497


Harvard Style

Abukamar, A. S., Abu-Awida, . M. M., Abughazaleh, . S. M., Abdallah, . A. R. & Al-Zghool, . H. M. (2020) POEMS syndrome: atypical presentation and therapeutic consideration. EJMCR, 4 (2), 65-69. doi:10.24911/ejmcr/173-1560698497


Turabian Style

Abukamar, Ayman S., Majdi M. Abu-Awida, Saeed M. Abughazaleh, Ahmad R. Abdallah, and Hamza M. Al-Zghool. 2020. POEMS syndrome: atypical presentation and therapeutic consideration. European Journal of Medical Case Reports, 4 (2), 65-69. doi:10.24911/ejmcr/173-1560698497


Chicago Style

Abukamar, Ayman S., Majdi M. Abu-Awida, Saeed M. Abughazaleh, Ahmad R. Abdallah, and Hamza M. Al-Zghool. "POEMS syndrome: atypical presentation and therapeutic consideration." European Journal of Medical Case Reports 4 (2020), 65-69. doi:10.24911/ejmcr/173-1560698497


MLA (The Modern Language Association) Style

Abukamar, Ayman S., Majdi M. Abu-Awida, Saeed M. Abughazaleh, Ahmad R. Abdallah, and Hamza M. Al-Zghool. "POEMS syndrome: atypical presentation and therapeutic consideration." European Journal of Medical Case Reports 4.2 (2020), 65-69. Print. doi:10.24911/ejmcr/173-1560698497


APA (American Psychological Association) Style

Abukamar, A. S., Abu-Awida, . M. M., Abughazaleh, . S. M., Abdallah, . A. R. & Al-Zghool, . H. M. (2020) POEMS syndrome: atypical presentation and therapeutic consideration. European Journal of Medical Case Reports, 4 (2), 65-69. doi:10.24911/ejmcr/173-1560698497


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