EJMCR. 2019; 3(2): 87-90
Authors: Asim Hassan, Saud Al Sifri, Mohammed Bilal Jaja, Mohammed Motasim Ali Haj Elamin.
Background: With the introduction of recombinant formulations insulin allergy is rare, occurring in less than 1% of patients treated with insulin. However, it is a serious situation requiring immediate attention, both due to the hypersensitivity reaction and severe life threatening glucose disequilibrium. Case presentation: A case of a 68-year-old male known diabetic for 35 years noticed some generalized itching, accompanied with maculopapular, mixed vasculitic and bullous lesions. Humalog Mix50/50 was stopped and patient was started on different combinations but to no avail. Before insulin desensitization a trial of degludec was given. Fortunately, the patient tolerated degludec and vildagliptin, and sugars came under control. Conclusion: This combination of multi-hexamer-forming ultra-long-acting insulin plus a DPP4 inhibitor vildagliptin could be an effective combination in controlling blood sugars in patients who have severe allergy to multiple drugs including oral hypoglycemic agents and various insulin preparations.
Keywords:
Insulin, allergy, Combination therapy, degludec, vildagliptin, case report
Hassan A, Sifri SA, Jaja MB, Elamin MMAH. Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. EJMCR. 2019; 3(2): 87-90. doi:10.24911/ejmcr/173-1553374788
Hassan A, Sifri SA, Jaja MB, Elamin MMAH. Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. http://www.ejmcr.com/?mno=38944 [Access: June 24, 2019]. doi:10.24911/ejmcr/173-1553374788
Hassan A, Sifri SA, Jaja MB, Elamin MMAH. Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. EJMCR. 2019; 3(2): 87-90. doi:10.24911/ejmcr/173-1553374788
Hassan A, Sifri SA, Jaja MB, Elamin MMAH. Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. EJMCR. (2019), [cited June 24, 2019]; 3(2): 87-90. doi:10.24911/ejmcr/173-1553374788
Hassan, A., Sifri, . S. A., Jaja, . M. B. & Elamin, . M. M. A. H. (2019) Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. EJMCR, 3 (2), 87-90. doi:10.24911/ejmcr/173-1553374788
Hassan, Asim, Saud Al Sifri, Mohammed Bilal Jaja, and Mohammed Motasim Ali Haj Elamin. 2019. Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. European Journal of Medical Case Reports, 3 (2), 87-90. doi:10.24911/ejmcr/173-1553374788
Hassan, Asim, Saud Al Sifri, Mohammed Bilal Jaja, and Mohammed Motasim Ali Haj Elamin. "Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report." European Journal of Medical Case Reports 3 (2019), 87-90. doi:10.24911/ejmcr/173-1553374788
Hassan, Asim, Saud Al Sifri, Mohammed Bilal Jaja, and Mohammed Motasim Ali Haj Elamin. "Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report." European Journal of Medical Case Reports 3.2 (2019), 87-90. Print. doi:10.24911/ejmcr/173-1553374788
Hassan, A., Sifri, . S. A., Jaja, . M. B. & Elamin, . M. M. A. H. (2019) Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. European Journal of Medical Case Reports, 3 (2), 87-90. doi:10.24911/ejmcr/173-1553374788
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