EJMCR. 2019; 3(2): 87-90

Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report

Authors: Asim Hassan, Saud Al Sifri, Mohammed Bilal Jaja, Mohammed Motasim Ali Haj Elamin.

ABSTRACT

Background: With the introduction of recombinant formulations insulin allergy is rare, occurring in less than 1% of patients treated with insulin. However, it is a serious situation requiring immediate attention, both due to the hypersensitivity reaction and severe life threatening glucose disequilibrium. Case presentation: A case of a 68-year-old male known diabetic for 35 years noticed some generalized itching, accompanied with maculopapular, mixed vasculitic and bullous lesions. Humalog Mix50/50 was stopped and patient was started on different combinations but to no avail. Before insulin desensitization a trial of degludec was given. Fortunately, the patient tolerated degludec and vildagliptin, and sugars came under control. Conclusion: This combination of multi-hexamer-forming ultra-long-acting insulin plus a DPP4 inhibitor vildagliptin could be an effective combination in controlling blood sugars in patients who have severe allergy to multiple drugs including oral hypoglycemic agents and various insulin preparations.

Keywords:
Insulin, allergy, Combination therapy, degludec, vildagliptin, case report


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Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report


Authors
Asim Hassan
Department of Diabetes and Endocrinology, Armed Forces Hospital AlHada, Taif, Saudi Arabia
PubMed articlesGoogle scholar articles

Saud Al Sifri
Department of Diabetes and Endocrinology, Armed Forces Hospital AlHada, Taif, Saudi Arabia
PubMed articlesGoogle scholar articles

Mohammed Bilal Jaja
Department of Diabetes and Endocrinology, Armed Forces Hospital AlHada, Taif, Saudi Arabia
PubMed articlesGoogle scholar articles

Mohammed Motasim Ali Haj Elamin
Department of Diabetes and Endocrinology, Armed Forces Hospital AlHada, Taif, Saudi Arabia
PubMed articlesGoogle scholar articles


Correspondence to:
. Asim Hassan##, Department of Diabetes and Endocrinology, Armed Forces Hospital AlHada, Taif, Saudi Arabia; drahassan2@hotmail.com

Publication history
Received 23 Mar 2019
Accepted 07 Apr 2019
Published in print 29 May 2019

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Pubmed Style

Hassan A, Sifri SA, Jaja MB, Elamin MMAH. Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. EJMCR. 2019; 3(2): 87-90. doi:10.24911/ejmcr/173-1553374788


Web Style

Hassan A, Sifri SA, Jaja MB, Elamin MMAH. Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. http://www.ejmcr.com/?mno=38944 [Access: August 19, 2019]. doi:10.24911/ejmcr/173-1553374788


AMA (American Medical Association) Style

Hassan A, Sifri SA, Jaja MB, Elamin MMAH. Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. EJMCR. 2019; 3(2): 87-90. doi:10.24911/ejmcr/173-1553374788


Vancouver/ICMJE Style

Hassan A, Sifri SA, Jaja MB, Elamin MMAH. Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. EJMCR. (2019), [cited August 19, 2019]; 3(2): 87-90. doi:10.24911/ejmcr/173-1553374788


Harvard Style

Hassan, A., Sifri, . S. A., Jaja, . M. B. & Elamin, . M. M. A. H. (2019) Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. EJMCR, 3 (2), 87-90. doi:10.24911/ejmcr/173-1553374788


Turabian Style

Hassan, Asim, Saud Al Sifri, Mohammed Bilal Jaja, and Mohammed Motasim Ali Haj Elamin. 2019. Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. European Journal of Medical Case Reports, 3 (2), 87-90. doi:10.24911/ejmcr/173-1553374788


Chicago Style

Hassan, Asim, Saud Al Sifri, Mohammed Bilal Jaja, and Mohammed Motasim Ali Haj Elamin. "Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report." European Journal of Medical Case Reports 3 (2019), 87-90. doi:10.24911/ejmcr/173-1553374788


MLA (The Modern Language Association) Style

Hassan, Asim, Saud Al Sifri, Mohammed Bilal Jaja, and Mohammed Motasim Ali Haj Elamin. "Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report." European Journal of Medical Case Reports 3.2 (2019), 87-90. Print. doi:10.24911/ejmcr/173-1553374788


APA (American Psychological Association) Style

Hassan, A., Sifri, . S. A., Jaja, . M. B. & Elamin, . M. M. A. H. (2019) Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. European Journal of Medical Case Reports, 3 (2), 87-90. doi:10.24911/ejmcr/173-1553374788


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