EJMCR. 2019; 3(2): 87-90

Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report

Authors: Asim Hassan , Bilal Jaja, Motasim Elamin, Saud Al Sifri.

ABSTRACT

Background: With the introduction of recombinant formulations insulin allergy is rare, occurring in less than 1% of patients treated with insulin. However, it is a serious situation requiring immediate attention, both due to the hypersensitivity reaction and severe life threatening glucose disequilibrium. Case presentation: A case of a 68-year-old male known diabetic for 35 years noticed some generalized itching, accompanied with maculopapular, mixed vasculitic and bullous lesions. Humalog Mix50/50 was stopped and patient was started on different combinations but to no avail. Before insulin desensitization a trial of degludec was given. Fortunately, the patient tolerated degludec and vildagliptin, and sugars came under control. Conclusion: This combination of multi-hexamer-forming ultra-long-acting insulin plus a DPP4 inhibitor vildagliptin could be an effective combination in controlling blood sugars in patients who have severe allergy to multiple drugs including oral hypoglycemic agents and various insulin preparations.

Keywords:
Insulin, allergy, Combination therapy, degludec, vildagliptin, case report


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Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report


Authors
Asim Hassan
Department of Diabetes and Endocrinology, Armed Forces Hospital AlHada, Taif, Saudi Arabia
PubMed articlesGoogle scholar articles

Bilal Jaja
Department of Diabetes and Endocrinology, Armed Forces Hospital AlHada, Taif, Saudi Arabia
PubMed articlesGoogle scholar articles

Motasim Elamin
Department of Diabetes and Endocrinology, Armed Forces Hospital AlHada, Taif, Saudi Arabia
PubMed articlesGoogle scholar articles

Saud Al Sifri
Department of Diabetes and Endocrinology, Armed Forces Hospital AlHada, Taif, Saudi Arabia
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Correspondence to:
. Asim Hassan, Department of Diabetes and Endocrinology, Armed Forces Hospital AlHada, Taif, Saudi Arabia; drahassan2@hotmail.com

Publication history
Received 23 Mar 2019
Accepted 07 Apr 2019
Published in print 29 May 2019

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Pubmed Style

AH, Jaja B, Elamin M, Sifri SA, . Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. EJMCR. 2019; 3(2): 87-90. doi:10.24911/ejmcr/173-1553374788


Web Style

AH, Jaja B, Elamin M, Sifri SA, . Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. https://www.ejmcr.com/?mno=38944 [Access: January 17, 2020]. doi:10.24911/ejmcr/173-1553374788


AMA (American Medical Association) Style

AH, Jaja B, Elamin M, Sifri SA, . Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. EJMCR. 2019; 3(2): 87-90. doi:10.24911/ejmcr/173-1553374788


Vancouver/ICMJE Style

AH, Jaja B, Elamin M, Sifri SA, . Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. EJMCR. (2019), [cited January 17, 2020]; 3(2): 87-90. doi:10.24911/ejmcr/173-1553374788


Harvard Style

, A. H., Jaja, . B., Elamin, . M., Sifri, . S. A. & (2019) Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. EJMCR, 3 (2), 87-90. doi:10.24911/ejmcr/173-1553374788


Turabian Style

, Asim Hassan, Bilal Jaja, Motasim Elamin, Saud Al Sifri, and . 2019. Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. European Journal of Medical Case Reports, 3 (2), 87-90. doi:10.24911/ejmcr/173-1553374788


Chicago Style

, Asim Hassan, Bilal Jaja, Motasim Elamin, Saud Al Sifri, and . "Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report." European Journal of Medical Case Reports 3 (2019), 87-90. doi:10.24911/ejmcr/173-1553374788


MLA (The Modern Language Association) Style

, Asim Hassan, Bilal Jaja, Motasim Elamin, Saud Al Sifri, and . "Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report." European Journal of Medical Case Reports 3.2 (2019), 87-90. Print. doi:10.24911/ejmcr/173-1553374788


APA (American Psychological Association) Style

, A. H., Jaja, . B., Elamin, . M., Sifri, . S. A. & (2019) Insulin Allergy Successfully Managed Using a Combination Of Multi-hexamer-forming Insulin Degludec and Vildagliptin-A case report. European Journal of Medical Case Reports, 3 (2), 87-90. doi:10.24911/ejmcr/173-1553374788


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