EJMCR. 2018; 2(Ultrasound Case Reports): -

Delta-9-tetrahydrocannabinol for the treatment of a child with Tourette syndrome - case report

Authors: Natalia Szejko, Ewgeni Jakubovski, Carolin Fremer, Katja Kunert, Kirsten Mueller-Vahl.

ABSTRACT

Background: Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder manifesting by motor and vocal tics. In severe, treatment resistant cases of TS cannabis-based medicine could be used alternatively as a rescue therapy Case presentation: We present the case of an 8-year-old boy with severe Tourette syndrome (TS) and comorbid attention deficit/hyperactivity disorder (ADHD) who significantly benefitted from treatment with cannabis-based medicine. During an episode with increased tics he became depressed, developed suicidal ideation and exhibited separation anxiety resulting in social isolation. As treatment with various antipsychotics and Habit Reversal Training turned out to be unsuccessful, we implemented therapy with oral delta-9-tetrahydrocannabinol (THC) as oil-based drops. Starting dose was as low as 0.7 mg THC/day once a day and was gradually increased up to maximum dose of 29.4 mg THC/day resulting in a significant improvement of both tics and behavioral symptoms. Follow-up visits over a period of 4 months demonstrated a sustained treatment effect without any adverse events. Conclusion: From this single case report it is suggested that THC is effective and safe in the treatment of tics, depression and ADHD in children with severe and otherwise treatment resistant TS.

Keywords:
case report, THC, Tourette syndrome, tics, cannabis, children


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Delta-9-tetrahydrocannabinol for the treatment of a child with Tourette syndrome - case report


Authors
Natalia Szejko
1. Clinic of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Germany 2. Department of Neurology, Medical University of Warsaw, Poland 3. Department of Bioethics, Medical University of Warsaw, Poland
PubMed articlesGoogle scholar articles

Ewgeni Jakubovski
Clinic of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Germany
PubMed articlesGoogle scholar articles

Carolin Fremer
Clinic of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Germany
PubMed articlesGoogle scholar articles

Katja Kunert
Clinic of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Germany
PubMed articlesGoogle scholar articles

Kirsten Mueller-Vahl
Clinic of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Germany
PubMed articlesGoogle scholar articles


Correspondence to:
Natalia Szejko. Natalia Szejko, 1. Clinic of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Germany 2. Department of Neurology, Medical University of Warsaw, Poland 3. Department of Bioethics, Medical University of Warsaw, Poland; natalia.szejko@gmail.com

Publication history
Published online 01 Jan 1970
Received 14 Feb 2018
Revised 08 Mar 2018
Accepted 11 Mar 2018

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Pubmed Style

Szejko N, Jakubovski E, Fremer C, Kunert K, Mueller-Vahl K. Delta-9-tetrahydrocannabinol for the treatment of a child with Tourette syndrome - case report. doi:10.24911/ejmcr/2/11


Web Style

Szejko N, Jakubovski E, Fremer C, Kunert K, Mueller-Vahl K. Delta-9-tetrahydrocannabinol for the treatment of a child with Tourette syndrome - case report. http://www.ejmcr.com/?mno=290920 [Access: May 25, 2018]. doi:10.24911/ejmcr/2/11


AMA (American Medical Association) Style

Szejko N, Jakubovski E, Fremer C, Kunert K, Mueller-Vahl K. Delta-9-tetrahydrocannabinol for the treatment of a child with Tourette syndrome - case report. doi:10.24911/ejmcr/2/11


Vancouver/ICMJE Style

Szejko N, Jakubovski E, Fremer C, Kunert K, Mueller-Vahl K. Delta-9-tetrahydrocannabinol for the treatment of a child with Tourette syndrome - case report. doi:10.24911/ejmcr/2/11


Harvard Style

Szejko, N., Jakubovski, E., Fremer, C., Kunert, K. & Mueller-Vahl, K. (2018) Delta-9-tetrahydrocannabinol for the treatment of a child with Tourette syndrome - case report. doi:10.24911/ejmcr/2/11


Turabian Style

Szejko, Natalia, Ewgeni Jakubovski, Carolin Fremer, Katja Kunert, and Kirsten Mueller-Vahl. 2018. Delta-9-tetrahydrocannabinol for the treatment of a child with Tourette syndrome - case report. doi:10.24911/ejmcr/2/11


Chicago Style

Szejko, Natalia, Ewgeni Jakubovski, Carolin Fremer, Katja Kunert, and Kirsten Mueller-Vahl. "Delta-9-tetrahydrocannabinol for the treatment of a child with Tourette syndrome - case report." doi:10.24911/ejmcr/2/11


MLA (The Modern Language Association) Style

Szejko, Natalia, Ewgeni Jakubovski, Carolin Fremer, Katja Kunert, and Kirsten Mueller-Vahl. "Delta-9-tetrahydrocannabinol for the treatment of a child with Tourette syndrome - case report." doi:10.24911/ejmcr/2/11


APA (American Psychological Association) Style

Szejko, N., Jakubovski, E., Fremer, C., Kunert, K. & Mueller-Vahl, K. (2018) Delta-9-tetrahydrocannabinol for the treatment of a child with Tourette syndrome - case report. doi:10.24911/ejmcr/2/11


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