Corona pandemic has unfurled its wings to disrupt the healthcare system of developing as well as developed countries and created havoc among healthcare professionals. Today, there is an atmosphere of trepidation at the possibility of getting new cure against this dreadful virus. People are looking with anxious eyes toward scientists to develop a vaccine against this virus. Already killed thousands of lives, this virus is spreading at a pace of fire. Some healthcare professionals and researchers are working out of the way to develop a new vaccine, and some are targeting the existing drug approach. Several successful trials were performed on Coronavirus disease-2019 (COVID-19) patients involving existing drugs in combination till date. This case series underlined those successful case studies of COVID-19. Different combinational approaches have been adopted by researchers such as the use of tissue plasminogen activators, extracorporeal membrane oxygenation and convalescent plasma therapy, intravenous immunoglobulins, antivirals drugs, antimalarials, antibiotics, interleukin antagonists, and corticosteroids to combat COVID-19. These therapies have corroborated to be constructive at some levels among individuals having a severe medical history as well as individuals without any profound medical history.

Keywords: Antiviral, COVID-19, corona, case studies, plasma therapy, virus, ultraviolet, ultrasonication