Case Report
Volume: 1 | Issue: 3 | Published: Jan 01, 1970 | Pages: 135 - 139 | DOI: 10.24911/ejmcr/1/32
Exceptional response after metronomic chemotherapy and palliative radiotherapy in castration-resistant prostate cancer: A case report
Authors: Alessio Giuseppe Morganti , Gabriella Macchia , Rezarta Frakulli , Andrea Milanoi , Francesco Massari , Maria Ntreta , Giambattista Siepe , Alessandra Arcelli , Silvia Cammelli , Giuseppe Zanirato Rambaldi , Michelangelo Fiorentino , Francesco Deodato
Article Info
Authors
Alessio Giuseppe Morganti
Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy
Gabriella Macchia
Radiotherapy Unit, Fondazione di Ricerca e Cura
Rezarta Frakulli
Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy
Andrea Milanoi
Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy
Francesco Massari
Medical Oncology Unit, Azienda Ospedaliera Universitaria, Policlinico S. Orsola-Malpighi, Bologna, Italy
Maria Ntreta
Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy
Giambattista Siepe
Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy
Alessandra Arcelli
Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy
Silvia Cammelli
Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy
Giuseppe Zanirato Rambaldi
Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy
Michelangelo Fiorentino
Pathology Unit, Addarii Institute, Azienda Ospedaliera Universitaria, Policlinico S. Orsola-Malpighi, Bologna,Italy
Francesco Deodato
Radiotherapy Unit, Fondazione di Ricerca e Cura
Publication History
Received: June 10, 2017
Revised: July 23, 2017
Accepted: July 31, 2017
Published: January 01, 1970
Abstract
Background Castration-resistant prostate cancer (CRPC) has a dismal prognosis. Despite treatment, median survival of these patients is around 12-22 months. Case Presentation In this report, we present the case of a 71-year-old man, with CRPC and painful bone metastases treated with an association of middle-half-body radiotherapy, androgen deprivation therapy (ADT) and cyclophosphamide-based metronomic chemotherapy. Five years after palliative radiotherapy the patient is still receiving metronomic chemotherapy and ADT. He is totally asymptomatic, with undetectable PSA values and negative 18F-Choline-PET/CT. The only side-effect was the development of non-insulin-dependent diabetes. Conclusion This treatment for its tolerability and feasibility, it could be particularly useful in older patients with CRPC. Furthermore, considering the low costs, it could be an important therapeutic option for patients living in low-resourced countries.
Keywords: Metronomic chemotherapy, radiotherapy, prostate neoplasms, CRPC, case report, green
