Case Report
Volume: 4 | Issue: 6 | Published: Jun 25, 2020 | Pages: 186 - 189 | DOI: 10.24911/ejmcr/173-1563277232
An unusual complication of hepatitis A: secondary hemophagocytic lymphohistiocytosis
Authors: Jayant Kumar Muduli , Meenakshi Mitra , Shweta Agarwal , Supriya Rashmi
Article Info
Authors
Jayant Kumar Muduli
Professor, Department of Pediatrics, IQ City Medical College and Narayana Multi-specialty Hospital, West Bengal, India
Meenakshi Mitra
Assistant Professor, Department of Pediatrics, IQ City Medical College and Narayana Multispecialty Hospital, West Bengal, India
Shweta Agarwal
Assistant Professor, Department of Pediatrics, IQ City Medical College and Narayana Multispecialty Hospital, West Bengal, India
Supriya Rashmi
Senior Resident, Department of Pediatrics, IQ City Medical College and Narayana Multi-specialty Hospital, West Bengal, India
Publication History
Received: July 30, 2019
Revised: April 10, 2020
Accepted: May 06, 2020
Published: June 25, 2020
Abstract
Background: Secondary hemophagocytic lymphohistiocytosis (HLH) is characterized by severe cytopenias due to uncontrolled hemophagocytosis. Other laboratory signs and clinical symptoms result from disordered immune regulation, and cytokine storm is well recognized. It is often a fatal complication of infections. It is not as uncommon as thought of previously. Case Presentation: We discuss a 7-year-old boy, born out of non-consanguineous marriage with acute hepatitis A infection, who developed HLH during treatment and was successfully managed with methyl prednisolone pulse therapy followed by oral prednisone therapy. Conclusion: Secondary HLH is a rare complication in a case of hepatitis A. A high index of suspicion at the early stage of HLH may produce a favorable outcome.
Keywords: Hemophagocytic lymphohistiocytosis, hepatitis A, injectable methyprednisolone, oral prednisolone, ferritin, triglycerides, green
