Case Report

Volume: 6 | Issue: 7 | Published: Oct 16, 2022 | Pages: 126 - 130 | DOI: 10.24911/ejmcr/173-1656920865

Non-seroconversion in an HIV-tuberculosis co-infected patient-case report


Authors: Fatima Kanani orcid logo , Nadia Asher , Maliha Zubairy


Article Info

Authors

Fatima Kanani

Department of Chemical Pathology, Indus Hospital and Health Network Karachi, Pakistan

orcid logo ORCID

Nadia Asher

Department of Chemical Pathology, Indus Hospital and Health Network Karachi, Pakistan

Maliha Zubairy

Department of Chemical Pathology, Indus Hospital and Health Network Karachi, Pakistan.

Publication History

Received: July 04, 2022

Revised: September 01, 2022

Accepted: September 01, 2022

Published: October 16, 2022


Abstract


Background: Most cases of negative serology in proven human immunodeficiency virus (HIV) patients occur due to testing during the window period. However, true non-seroconversion is a phenomenon that should always be considered. Case Presentation: A 13-year-old female with a family history of multi-drug resistant tuberculosis (MDR-TB) presented with cough without fever for 1 month. She was vitally stable and the physical examination was unremarkable. Chest X-ray was suggestive of active TB, sputum positive for acid-fast bacilli, and GeneXpert positive for Mycobacterium tuberculosis. Her HIV RNA polymerase chain reaction (PCR) was positive at 28,866 IU/ml. She was registered as presumed MDR-TB and started on anti-tuberculosis treatment. Serum specimen sent inadvertently 6 weeks later was positive for HIV- p24 antigen while negative for anti-HIV ½ on Determine HIV Early Detect fourth generation lateral flow assay. A fresh specimen 2 weeks later showed similar results and was also negative by Alinity HIV Ag/antibody Combo (Abbott Diagnostics) and Bio-Rad Geenius HIV-1/2 Supplemental Assay. HIV antibodies were still negative at 20 weeks (5 months) after positive PCR. Conclusion: This is a case of a seronegative HIV/TB co-infected patient. Non-seroconversion should always be considered in patients with clinical suspicion and discordant results.

Keywords: Seroconversion, tuberculosis, acquired immunodeficiency syndrome, human immunodeficiency virus, case report, green


Pubmed Style

Fatima Kanani, Nadia Asher, Maliha Zubairy. Non-seroconversion in an HIV-tuberculosis co-infected patient-case report. EJMCR. 2022; 16 (October 2022): 126-130. doi:10.24911/ejmcr/173-1656920865

Web Style

Fatima Kanani, Nadia Asher, Maliha Zubairy. Non-seroconversion in an HIV-tuberculosis co-infected patient-case report. https://ejmcr.com/articles/1099 [Access: December 25, 2024]. doi:10.24911/ejmcr/173-1656920865

AMA (American Medical Association) Style

Fatima Kanani, Nadia Asher, Maliha Zubairy. Non-seroconversion in an HIV-tuberculosis co-infected patient-case report. EJMCR. 2022; 16 (October 2022): 126-130. doi:10.24911/ejmcr/173-1656920865

Vancouver/ICMJE Style

Fatima Kanani, Nadia Asher, Maliha Zubairy. Non-seroconversion in an HIV-tuberculosis co-infected patient-case report. EJMCR. (2022), [cited December 25, 2024]; 16 (October 2022): 126-130. doi:10.24911/ejmcr/173-1656920865

Harvard Style

Fatima Kanani, Nadia Asher, Maliha Zubairy (2022) Non-seroconversion in an HIV-tuberculosis co-infected patient-case report. EJMCR, 16 (October 2022): 126-130. doi:10.24911/ejmcr/173-1656920865

Chicago Style

Fatima Kanani, Nadia Asher, Maliha Zubairy. "Non-seroconversion in an HIV-tuberculosis co-infected patient-case report." 16 (2022), 126-130. doi:10.24911/ejmcr/173-1656920865

MLA (The Modern Language Association) Style

Fatima Kanani, Nadia Asher, Maliha Zubairy. "Non-seroconversion in an HIV-tuberculosis co-infected patient-case report." 16.October 2022 (2022), 126-130. Print. doi:10.24911/ejmcr/173-1656920865

APA (American Psychological Association) Style

Fatima Kanani, Nadia Asher, Maliha Zubairy (2022) Non-seroconversion in an HIV-tuberculosis co-infected patient-case report. , 16 (October 2022), 126-130. doi:10.24911/ejmcr/173-1656920865