Case Report

Volume: 6 | Issue: 4 | Published: Jul 07, 2022 | Pages: 64 - 67 | DOI: 10.24911/ejmcr/173-1640961455

Fever with pancytopenia in a patient with lamotrigin induced DRESS syndrome: a case-based review


Authors: Dimitris Kounatidis , Christina Vourlakou , Fotis Panagopoulos , Ioanna Papaodyssea , Eugenia Grivakou , Vasilis Stamatopoulos , Alexandros Skourtis , Natalia Vallianou


Article Info

Authors

Dimitris Kounatidis

Department of Internal Medicine, Evangelismos General Hospital, Athens, Greece

Christina Vourlakou

Department of Internal Medicine, Evangelismos General Hospital, Athens, Greece

Fotis Panagopoulos

Department of Internal Medicine, Evangelismos General Hospital, Athens, Greece

Ioanna Papaodyssea

Department of Internal Medicine, Evangelismos General Hospital, Athens, Greece

Eugenia Grivakou

Department of Internal Medicine, Evangelismos General Hospital, Athens, Greece

Vasilis Stamatopoulos

Department of Internal Medicine, Evangelismos General Hospital, Athens, Greece

Alexandros Skourtis

Department of Internal Medicine, Evangelismos General Hospital, Athens, Greece

Natalia Vallianou

Department of Internal Medicine, Evangelismos General Hospital, Athens, Greece.

Publication History

Received: December 31, 2021

Accepted:

Published: July 07, 2022


Abstract


Background: Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a rare idiosyncratic and unpredictable drug reaction most commonly attributed to anticonvulsants, allopurinol, and antibiotics. Fever in combination with cutaneous manifestations and eosinophilia are the cardinal clinical findings, while organ involvement and very rarely pancytopenia can be present. Case presentation: We describe a 26-year-old female patient with pancytopenia in the context of lamotrigine-induced DRESS and we summarize this as a potentially life-threatening hypersensitivity reaction. Conclusion: DRESS should be suspected in patients presenting with fever, eosinophilia, skin involvement, and/or visceral organ involvement, who have started a new drug during the past 2 to 6 weeks, as early recognition of this syndrome with subsequent discontinuation of the offending drug could be lifesaving.

Keywords: DRESS, lamotrigine, hypersensitivity reaction, pancytopenia, green


Pubmed Style

Dimitris Kounatidis, Christina Vourlakou, Fotis Panagopoulos, Ioanna Papaodyssea, Eugenia Grivakou, Vasilis Stamatopoulos, Alexandros Skourtis, Natalia Vallianou. Fever with pancytopenia in a patient with lamotrigin induced DRESS syndrome: a case-based review. EJMCR. 2022; 07 (July 2022): 64-67. doi:10.24911/ejmcr/173-1640961455

Web Style

Dimitris Kounatidis, Christina Vourlakou, Fotis Panagopoulos, Ioanna Papaodyssea, Eugenia Grivakou, Vasilis Stamatopoulos, Alexandros Skourtis, Natalia Vallianou. Fever with pancytopenia in a patient with lamotrigin induced DRESS syndrome: a case-based review. https://ejmcr.com/articles/1088 [Access: December 25, 2024]. doi:10.24911/ejmcr/173-1640961455

AMA (American Medical Association) Style

Dimitris Kounatidis, Christina Vourlakou, Fotis Panagopoulos, Ioanna Papaodyssea, Eugenia Grivakou, Vasilis Stamatopoulos, Alexandros Skourtis, Natalia Vallianou. Fever with pancytopenia in a patient with lamotrigin induced DRESS syndrome: a case-based review. EJMCR. 2022; 07 (July 2022): 64-67. doi:10.24911/ejmcr/173-1640961455

Vancouver/ICMJE Style

Dimitris Kounatidis, Christina Vourlakou, Fotis Panagopoulos, Ioanna Papaodyssea, Eugenia Grivakou, Vasilis Stamatopoulos, Alexandros Skourtis, Natalia Vallianou. Fever with pancytopenia in a patient with lamotrigin induced DRESS syndrome: a case-based review. EJMCR. (2022), [cited December 25, 2024]; 07 (July 2022): 64-67. doi:10.24911/ejmcr/173-1640961455

Harvard Style

Dimitris Kounatidis, Christina Vourlakou, Fotis Panagopoulos, Ioanna Papaodyssea, Eugenia Grivakou, Vasilis Stamatopoulos, Alexandros Skourtis, Natalia Vallianou (2022) Fever with pancytopenia in a patient with lamotrigin induced DRESS syndrome: a case-based review. EJMCR, 07 (July 2022): 64-67. doi:10.24911/ejmcr/173-1640961455

Chicago Style

Dimitris Kounatidis, Christina Vourlakou, Fotis Panagopoulos, Ioanna Papaodyssea, Eugenia Grivakou, Vasilis Stamatopoulos, Alexandros Skourtis, Natalia Vallianou. "Fever with pancytopenia in a patient with lamotrigin induced DRESS syndrome: a case-based review." 07 (2022), 64-67. doi:10.24911/ejmcr/173-1640961455

MLA (The Modern Language Association) Style

Dimitris Kounatidis, Christina Vourlakou, Fotis Panagopoulos, Ioanna Papaodyssea, Eugenia Grivakou, Vasilis Stamatopoulos, Alexandros Skourtis, Natalia Vallianou. "Fever with pancytopenia in a patient with lamotrigin induced DRESS syndrome: a case-based review." 07.July 2022 (2022), 64-67. Print. doi:10.24911/ejmcr/173-1640961455

APA (American Psychological Association) Style

Dimitris Kounatidis, Christina Vourlakou, Fotis Panagopoulos, Ioanna Papaodyssea, Eugenia Grivakou, Vasilis Stamatopoulos, Alexandros Skourtis, Natalia Vallianou (2022) Fever with pancytopenia in a patient with lamotrigin induced DRESS syndrome: a case-based review. , 07 (July 2022), 64-67. doi:10.24911/ejmcr/173-1640961455