Case Report

Volume: 5 | Issue: 6 | Published: Jun 23, 2021 | Pages: 187 - 190 | DOI: 10.24911/ejmcr/173-1614468533

A case of chronic asymptomatic hypercalcemia in an individual with insulin resistance syndrome

Authors: Neil Roy , Sylvia Rosas

Article Info

Authors

Neil Roy

Kidney and Hypertension Unit, Joslin Diabetes Center, Harvard Medical School, Boston, MA

Sylvia Rosas

Kidney and Hypertension Unit, Joslin Diabetes Center, Harvard Medical School, Boston, MA

Publication History

Received: March 01, 2021

Revised: May 10, 2021

Accepted: May 25, 2021

Published: June 23, 2021

Abstract

Background: Calcium, the major inorganic component in bone, plays an important role in insulin secretion and insulin resistance. Insulin resistance is essential in the pathophysiology of non-alcoholic steatohepatitis (NASH), polycystic ovarian syndrome (PCOS), and Type 2 diabetes mellitus (DM). Case Presentation: We present a case of chronic asymptomatic hypercalcemia in an individual with NASH, PCOS, and DM. She was noted to have a serum calcium of 12.8 mg/dl and a homeostatic model assessment of insulin resistance (HOMA-IR) of 4.7 in the last 2 years. Almost all other causes of hypercalcemia were ruled out. The patient was treated conservatively and advised to avoid factors that can aggravate hypercalcemia. Conclusion: The insulin effect on calcium homeostasis is impaired in conditions of insulin resistance. There is increasing evidence of the association between hypercalcemia and insulin resistance. However, it remains a diagnosis of exclusion.

Keywords: Liver disease, hypercalcemia, non-alcoholic steatohepatitis, insulin resistance, diabetes mellitus, green

Open access Creative Commons License

Pubmed Style

Neil Roy, Sylvia Rosas. A case of chronic asymptomatic hypercalcemia in an individual with insulin resistance syndrome. EJMCR. 2021; 23 (June 2021): 187-190. doi:10.24911/ejmcr/173-1614468533

Web Style

Neil Roy, Sylvia Rosas. A case of chronic asymptomatic hypercalcemia in an individual with insulin resistance syndrome. https://ejmcr.com/articles/1313 [Access: December 25, 2024]. doi:10.24911/ejmcr/173-1614468533

AMA (American Medical Association) Style

Neil Roy, Sylvia Rosas. A case of chronic asymptomatic hypercalcemia in an individual with insulin resistance syndrome. EJMCR. 2021; 23 (June 2021): 187-190. doi:10.24911/ejmcr/173-1614468533

Vancouver/ICMJE Style

Neil Roy, Sylvia Rosas. A case of chronic asymptomatic hypercalcemia in an individual with insulin resistance syndrome. EJMCR. (2021), [cited December 25, 2024]; 23 (June 2021): 187-190. doi:10.24911/ejmcr/173-1614468533

Harvard Style

Neil Roy, Sylvia Rosas (2021) A case of chronic asymptomatic hypercalcemia in an individual with insulin resistance syndrome. EJMCR, 23 (June 2021): 187-190. doi:10.24911/ejmcr/173-1614468533

Chicago Style

Neil Roy, Sylvia Rosas. "A case of chronic asymptomatic hypercalcemia in an individual with insulin resistance syndrome." 23 (2021), 187-190. doi:10.24911/ejmcr/173-1614468533

MLA (The Modern Language Association) Style

Neil Roy, Sylvia Rosas. "A case of chronic asymptomatic hypercalcemia in an individual with insulin resistance syndrome." 23.June 2021 (2021), 187-190. Print. doi:10.24911/ejmcr/173-1614468533

APA (American Psychological Association) Style

Neil Roy, Sylvia Rosas (2021) A case of chronic asymptomatic hypercalcemia in an individual with insulin resistance syndrome. , 23 (June 2021), 187-190. doi:10.24911/ejmcr/173-1614468533