Case Report

Volume: 5 | Issue: 6 | Published: Jun 17, 2021 | Pages: 177 - 181 | DOI: 10.24911/ejmcr/173-1612900450

Multifocal secondary amyloidosis and Whipple disease: a case report


Authors: Margarida Carrolo , Joao Cruz , Susana Livramento


Article Info

Authors

Margarida Carrolo

Department of Internal Medicine, Hospital CUF Descobertas, Lisboa, Portugal

Joao Cruz

Department of Anatomic Pathology, Hospital CUF Descobertas, Lisboa, Portugal

Susana Livramento

Department of Internal Medicine, Hospital CUF Descobertas, Lisboa, Portugal

Publication History

Received: February 09, 2021

Revised: March 27, 2021

Accepted: May 22, 2021

Published: June 17, 2021


Abstract


Background: Whipple disease (WD) is an exceedingly rare disease. Despite its rarity, there has been a longstanding allure with this disease. The classic form manifests with arthralgia, weight loss, abdominal pain, and diarrhea. However, the infection may involve other organs causing a great diversity of symptoms. Case Presentation: We report a case of a patient presenting to the emergency room with weight loss, abdominal pain and diarrhea. Duodenal biopsies revealed periodic acid Schiff-positive macrophages and Tropheryma whipplei was detected on a cervical lymph node. Diagnosis of WD was established. The patient also had multifocal secondary amyloidosis. We started the patient on a standardized antibiotic regimen for 1 year. Clinical improvement was seen early during the treatment. Conclusion: This case is an example of the protean nature of WD. To the authorsÂ’ knowledge, this is the first case report on WD with multifocal secondary amyloidosis affecting several digestive organs.

Keywords: Whipple disease, Tropheryma whipplei, PAS-positive macrophages, secondary amyloidosis, case report, green


Pubmed Style

Margarida Carrolo, Joao Cruz, Susana Livramento. Multifocal secondary amyloidosis and Whipple disease: a case report. EJMCR. 2021; 17 (June 2021): 177-181. doi:10.24911/ejmcr/173-1612900450

Web Style

Margarida Carrolo, Joao Cruz, Susana Livramento. Multifocal secondary amyloidosis and Whipple disease: a case report. https://ejmcr.com/articles/1311 [Access: December 25, 2024]. doi:10.24911/ejmcr/173-1612900450

AMA (American Medical Association) Style

Margarida Carrolo, Joao Cruz, Susana Livramento. Multifocal secondary amyloidosis and Whipple disease: a case report. EJMCR. 2021; 17 (June 2021): 177-181. doi:10.24911/ejmcr/173-1612900450

Vancouver/ICMJE Style

Margarida Carrolo, Joao Cruz, Susana Livramento. Multifocal secondary amyloidosis and Whipple disease: a case report. EJMCR. (2021), [cited December 25, 2024]; 17 (June 2021): 177-181. doi:10.24911/ejmcr/173-1612900450

Harvard Style

Margarida Carrolo, Joao Cruz, Susana Livramento (2021) Multifocal secondary amyloidosis and Whipple disease: a case report. EJMCR, 17 (June 2021): 177-181. doi:10.24911/ejmcr/173-1612900450

Chicago Style

Margarida Carrolo, Joao Cruz, Susana Livramento. "Multifocal secondary amyloidosis and Whipple disease: a case report." 17 (2021), 177-181. doi:10.24911/ejmcr/173-1612900450

MLA (The Modern Language Association) Style

Margarida Carrolo, Joao Cruz, Susana Livramento. "Multifocal secondary amyloidosis and Whipple disease: a case report." 17.June 2021 (2021), 177-181. Print. doi:10.24911/ejmcr/173-1612900450

APA (American Psychological Association) Style

Margarida Carrolo, Joao Cruz, Susana Livramento (2021) Multifocal secondary amyloidosis and Whipple disease: a case report. , 17 (June 2021), 177-181. doi:10.24911/ejmcr/173-1612900450