Case Report
Volume: 5 | Issue: 6 | Published: Jun 17, 2021 | Pages: 177 - 181 | DOI: 10.24911/ejmcr/173-1612900450
Multifocal secondary amyloidosis and Whipple disease: a case report
Authors: Margarida Carrolo , Joao Cruz , Susana Livramento
Article Info
Authors
Margarida Carrolo
Department of Internal Medicine, Hospital CUF Descobertas, Lisboa, Portugal
Joao Cruz
Department of Anatomic Pathology, Hospital CUF Descobertas, Lisboa, Portugal
Susana Livramento
Department of Internal Medicine, Hospital CUF Descobertas, Lisboa, Portugal
Publication History
Received: February 09, 2021
Revised: March 27, 2021
Accepted: May 22, 2021
Published: June 17, 2021
Abstract
Background: Whipple disease (WD) is an exceedingly rare disease. Despite its rarity, there has been a longstanding allure with this disease. The classic form manifests with arthralgia, weight loss, abdominal pain, and diarrhea. However, the infection may involve other organs causing a great diversity of symptoms. Case Presentation: We report a case of a patient presenting to the emergency room with weight loss, abdominal pain and diarrhea. Duodenal biopsies revealed periodic acid Schiff-positive macrophages and Tropheryma whipplei was detected on a cervical lymph node. Diagnosis of WD was established. The patient also had multifocal secondary amyloidosis. We started the patient on a standardized antibiotic regimen for 1 year. Clinical improvement was seen early during the treatment. Conclusion: This case is an example of the protean nature of WD. To the authorsÂ’ knowledge, this is the first case report on WD with multifocal secondary amyloidosis affecting several digestive organs.
Keywords: Whipple disease, Tropheryma whipplei, PAS-positive macrophages, secondary amyloidosis, case report, green
Pubmed Style
Margarida Carrolo, Joao Cruz, Susana Livramento. Multifocal secondary amyloidosis and Whipple disease: a case report. EJMCR. 2021; 17 (June 2021): 177-181. doi:10.24911/ejmcr/173-1612900450
Web Style
Margarida Carrolo, Joao Cruz, Susana Livramento. Multifocal secondary amyloidosis and Whipple disease: a case report. https://ejmcr.com/articles/1311 [Access: November 23, 2024]. doi:10.24911/ejmcr/173-1612900450
AMA (American Medical Association) Style
Margarida Carrolo, Joao Cruz, Susana Livramento. Multifocal secondary amyloidosis and Whipple disease: a case report. EJMCR. 2021; 17 (June 2021): 177-181. doi:10.24911/ejmcr/173-1612900450
Vancouver/ICMJE Style
Margarida Carrolo, Joao Cruz, Susana Livramento. Multifocal secondary amyloidosis and Whipple disease: a case report. EJMCR. (2021), [cited November 23, 2024]; 17 (June 2021): 177-181. doi:10.24911/ejmcr/173-1612900450
Harvard Style
Margarida Carrolo, Joao Cruz, Susana Livramento (2021) Multifocal secondary amyloidosis and Whipple disease: a case report. EJMCR, 17 (June 2021): 177-181. doi:10.24911/ejmcr/173-1612900450
Chicago Style
Margarida Carrolo, Joao Cruz, Susana Livramento. "Multifocal secondary amyloidosis and Whipple disease: a case report." 17 (2021), 177-181. doi:10.24911/ejmcr/173-1612900450
MLA (The Modern Language Association) Style
Margarida Carrolo, Joao Cruz, Susana Livramento. "Multifocal secondary amyloidosis and Whipple disease: a case report." 17.June 2021 (2021), 177-181. Print. doi:10.24911/ejmcr/173-1612900450
APA (American Psychological Association) Style
Margarida Carrolo, Joao Cruz, Susana Livramento (2021) Multifocal secondary amyloidosis and Whipple disease: a case report. , 17 (June 2021), 177-181. doi:10.24911/ejmcr/173-1612900450