Case Report
Volume: 5 | Issue: 1 | Published: Jan 22, 2021 | Pages: 7 - 11 | DOI: 10.24911/ejmcr/173-1584863716
Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report
Authors: Ioannis Provatas , Dimitrios Sabaziotis , Chrissa Stamou , Georgia Mitropoulou , Helen Trihia
Article Info
Authors
Ioannis Provatas
Department of Pathology, Athens General Hospital "O Evangelismos", Athens, Greece
Dimitrios Sabaziotis
Department of Pathology, Athens General Hospital "O Evangelismos", Athens, Greece
Chrissa Stamou
Department of Pathology, Athens General Hospital "O Evangelismos", Athens, Greece
Georgia Mitropoulou
Department of Pathology, Athens Children s Hospital Agia Sofia, Athens, Greece
Helen Trihia
Department of Pathology, Cancer Hospital of Pireaus Metaxa, Piraeus, Greece
Publication History
Received: March 22, 2020
Revised: September 26, 2020
Accepted: September 26, 2020
Published: January 22, 2021
Abstract
Background: Extraosseous giant cell tumors involving visceral organs (pancreas, kidneys, bladder, etc.) and soft tissues present similar histological features to those occurring in the bones. Rarely, they may affect pancreas and their origin remains still controversial, with some authors supporting the epithelial and some others the mesenchymal origin. Case Presentation: We report the case of a pancreatic giant cell tumor with osteoclast-like cells, negative for epithelial markers. A 64-year-old man presented with a 2-month history of progressively worsening abdominal pain, radiating to the lumbar region. He reported no other symptoms. The abdominal clinical examination was unremarkable and there was no associated jaundice. Liver function tests remained within normal limits. His past medical history had nil of note. He underwent an outpatient abdominal computed tomography which revealed a large cystic lesion at the body of the pancreas measuring 10 × 7 × 6.5 cm. We proceeded with a limited excision of the pancreatic mass alone, avoiding major dissections that would unnecessarily increase morbidity and mortality and the postoperative course was good. The histological morphological and immunohistochemical assessment revealed two tumor cell types: osteoclast-like multinucleated giant cells and pleomorphic mononuclear cells, with bone formation and without important cellular and nuclear atypia. Conclusion: Pancreatic giant cell tumors with osteoclast-like giant cells are rare tumors of the pancreas with various clinical characteristics and controversial origin. En bloc resection has prevailed as the only beneficial treatment so far.
Keywords: Osteoclastic giant cell tumor of the pancreas, bone, osteoid, green
Pubmed Style
Ioannis Provatas, Dimitrios Sabaziotis, Chrissa Stamou, Georgia Mitropoulou, Helen Trihia. Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report. EJMCR. 2021; 22 (January 2021): 7-11. doi:10.24911/ejmcr/173-1584863716
Web Style
Ioannis Provatas, Dimitrios Sabaziotis, Chrissa Stamou, Georgia Mitropoulou, Helen Trihia. Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report. https://ejmcr.com/articles/1114 [Access: December 25, 2024]. doi:10.24911/ejmcr/173-1584863716
AMA (American Medical Association) Style
Ioannis Provatas, Dimitrios Sabaziotis, Chrissa Stamou, Georgia Mitropoulou, Helen Trihia. Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report. EJMCR. 2021; 22 (January 2021): 7-11. doi:10.24911/ejmcr/173-1584863716
Vancouver/ICMJE Style
Ioannis Provatas, Dimitrios Sabaziotis, Chrissa Stamou, Georgia Mitropoulou, Helen Trihia. Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report. EJMCR. (2021), [cited December 25, 2024]; 22 (January 2021): 7-11. doi:10.24911/ejmcr/173-1584863716
Harvard Style
Ioannis Provatas, Dimitrios Sabaziotis, Chrissa Stamou, Georgia Mitropoulou, Helen Trihia (2021) Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report. EJMCR, 22 (January 2021): 7-11. doi:10.24911/ejmcr/173-1584863716
Chicago Style
Ioannis Provatas, Dimitrios Sabaziotis, Chrissa Stamou, Georgia Mitropoulou, Helen Trihia. "Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report." 22 (2021), 7-11. doi:10.24911/ejmcr/173-1584863716
MLA (The Modern Language Association) Style
Ioannis Provatas, Dimitrios Sabaziotis, Chrissa Stamou, Georgia Mitropoulou, Helen Trihia. "Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report." 22.January 2021 (2021), 7-11. Print. doi:10.24911/ejmcr/173-1584863716
APA (American Psychological Association) Style
Ioannis Provatas, Dimitrios Sabaziotis, Chrissa Stamou, Georgia Mitropoulou, Helen Trihia (2021) Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report. , 22 (January 2021), 7-11. doi:10.24911/ejmcr/173-1584863716