EJMCR |

Case Report

Volume: 4 | Issue: 5 | Published: May 26, 2020 | Pages: 157 - 160 | DOI: 10.24911/ejmcr/173-1570436579

A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?

Authors: Andreas Eleftheriou , Martin Nilsson , Fredrik Lundin

Authors

Andreas Eleftheriou

Department of Neurology and Department of Biomedical and Clinical Sciences, Division of Neurobiology, Linkoping University, Linkoping, Sweden

Martin Nilsson

Department of Neurosurgery in Linkoping, and Department of Biomedical and Clinical Sciences, Linkoping University, Linkoping, Sweden

Fredrik Lundin

Department of Neurology and Department of Biomedical and Clinical Sciences, Division of Neurobiology, Linkoping University, Linkoping, Sweden

Publication History

Received: October 07, 2019

Revised: April 19, 2020

Accepted: May 02, 2020

Published: May 26, 2020

Abstract

Background: Idiopathic normal pressure hydrocephalus (iNPH) is usually regarded as a disease characterized by gait and balance disturbance, cognitive dysfunction, and urinary symptoms. The pathophysiology of iNPH is still unknown, but the increased number of familial cases raises the suspicion of a genetic component. The C9ORF72 expansion is known to cause frontotemporal lobar degeneration and ALS, and its prevalence is found among Finnish iNPH patients. Case Presentation: We report an interesting case of a patient with possible iNPH who also developed ALS. Conclusion: Our case raises the theory of coexistence of gene-induced etiology. Key Message: Our case also raises the question of a genetic link between iNPH and ALS.

Keywords: Idiopathic normal pressure hydrocephalus, familial, C9ORF72 expansion, ALS, green

Pubmed Style

Andreas Eleftheriou, Martin Nilsson, Fredrik Lundin. A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?. EJMCR. 2020; 26 (May 2020): 157-160. doi:10.24911/ejmcr/173-1570436579

Web Style

Andreas Eleftheriou, Martin Nilsson, Fredrik Lundin. A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?. https://ejmcr.com/articles/1426 [Access: December 04, 2024]. doi:10.24911/ejmcr/173-1570436579

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Andreas Eleftheriou, Martin Nilsson, Fredrik Lundin. A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?. EJMCR. (2020), [cited December 04, 2024]; 26 (May 2020): 157-160. doi:10.24911/ejmcr/173-1570436579

Harvard Style

Andreas Eleftheriou, Martin Nilsson, Fredrik Lundin (2020) A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?. EJMCR, 26 (May 2020): 157-160. doi:10.24911/ejmcr/173-1570436579

Chicago Style

Andreas Eleftheriou, Martin Nilsson, Fredrik Lundin. "A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?." 26 (2020), 157-160. doi:10.24911/ejmcr/173-1570436579

MLA (The Modern Language Association) Style

Andreas Eleftheriou, Martin Nilsson, Fredrik Lundin. "A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?." 26.May 2020 (2020), 157-160. Print. doi:10.24911/ejmcr/173-1570436579

APA (American Psychological Association) Style

Andreas Eleftheriou, Martin Nilsson, Fredrik Lundin (2020) A patient with idiopathic normal pressure hydrocephalus and amyotrophic lateral sclerosis. Coincidence or a genetic link between the diseases?. , 26 (May 2020), 157-160. doi:10.24911/ejmcr/173-1570436579