Case Report

Volume: 1 | Issue: 3 | Published: Jan 01, 1970 | Pages: 135 - 139 | DOI: 10.24911/ejmcr/1/32

Exceptional response after metronomic chemotherapy and palliative radiotherapy in castration-resistant prostate cancer: A case report


Authors: Alessio Giuseppe Morganti , Gabriella Macchia , Rezarta Frakulli , Andrea Milanoi , Francesco Massari , Maria Ntreta , Giambattista Siepe , Alessandra Arcelli , Silvia Cammelli , Giuseppe Zanirato Rambaldi , Michelangelo Fiorentino , Francesco Deodato


Article Info

Authors

Alessio Giuseppe Morganti

Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

Gabriella Macchia

Radiotherapy Unit, Fondazione di Ricerca e Cura

Rezarta Frakulli

Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

Andrea Milanoi

Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

Francesco Massari

Medical Oncology Unit, Azienda Ospedaliera Universitaria, Policlinico S. Orsola-Malpighi, Bologna, Italy

Maria Ntreta

Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

Giambattista Siepe

Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

Alessandra Arcelli

Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

Silvia Cammelli

Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

Giuseppe Zanirato Rambaldi

Radiotherapy Center, Departments of Experimental, Diagnostic and Specialty Medicine - DIMES Radiation Oncology Center, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

Michelangelo Fiorentino

Pathology Unit, Addarii Institute, Azienda Ospedaliera Universitaria, Policlinico S. Orsola-Malpighi, Bologna,Italy

Francesco Deodato

Radiotherapy Unit, Fondazione di Ricerca e Cura

Publication History

Received: June 10, 2017

Revised: July 23, 2017

Accepted: July 31, 2017

Published: January 01, 1970


Abstract


Background Castration-resistant prostate cancer (CRPC) has a dismal prognosis. Despite treatment, median survival of these patients is around 12-22 months. Case Presentation In this report, we present the case of a 71-year-old man, with CRPC and painful bone metastases treated with an association of middle-half-body radiotherapy, androgen deprivation therapy (ADT) and cyclophosphamide-based metronomic chemotherapy. Five years after palliative radiotherapy the patient is still receiving metronomic chemotherapy and ADT. He is totally asymptomatic, with undetectable PSA values and negative 18F-Choline-PET/CT. The only side-effect was the development of non-insulin-dependent diabetes. Conclusion This treatment for its tolerability and feasibility, it could be particularly useful in older patients with CRPC. Furthermore, considering the low costs, it could be an important therapeutic option for patients living in low-resourced countries.

Keywords: Metronomic chemotherapy, radiotherapy, prostate neoplasms, CRPC, case report, green


Pubmed Style

Alessio Giuseppe Morganti, Gabriella Macchia, Rezarta Frakulli, Andrea Milanoi, Francesco Massari, Maria Ntreta, Giambattista Siepe, Alessandra Arcelli, Silvia Cammelli, Giuseppe Zanirato Rambaldi, Michelangelo Fiorentino, Francesco Deodato. Exceptional response after metronomic chemotherapy and palliative radiotherapy in castration-resistant prostate cancer: A case report. EJMCR. 1970; 01 (January 1970): 135-139. doi:10.24911/ejmcr/1/32

Web Style

Alessio Giuseppe Morganti, Gabriella Macchia, Rezarta Frakulli, Andrea Milanoi, Francesco Massari, Maria Ntreta, Giambattista Siepe, Alessandra Arcelli, Silvia Cammelli, Giuseppe Zanirato Rambaldi, Michelangelo Fiorentino, Francesco Deodato. Exceptional response after metronomic chemotherapy and palliative radiotherapy in castration-resistant prostate cancer: A case report. https://ejmcr.com/articles/1524 [Access: December 25, 2024]. doi:10.24911/ejmcr/1/32

AMA (American Medical Association) Style

Alessio Giuseppe Morganti, Gabriella Macchia, Rezarta Frakulli, Andrea Milanoi, Francesco Massari, Maria Ntreta, Giambattista Siepe, Alessandra Arcelli, Silvia Cammelli, Giuseppe Zanirato Rambaldi, Michelangelo Fiorentino, Francesco Deodato. Exceptional response after metronomic chemotherapy and palliative radiotherapy in castration-resistant prostate cancer: A case report. EJMCR. 1970; 01 (January 1970): 135-139. doi:10.24911/ejmcr/1/32

Vancouver/ICMJE Style

Alessio Giuseppe Morganti, Gabriella Macchia, Rezarta Frakulli, Andrea Milanoi, Francesco Massari, Maria Ntreta, Giambattista Siepe, Alessandra Arcelli, Silvia Cammelli, Giuseppe Zanirato Rambaldi, Michelangelo Fiorentino, Francesco Deodato. Exceptional response after metronomic chemotherapy and palliative radiotherapy in castration-resistant prostate cancer: A case report. EJMCR. (1970), [cited December 25, 2024]; 01 (January 1970): 135-139. doi:10.24911/ejmcr/1/32

Harvard Style

Alessio Giuseppe Morganti, Gabriella Macchia, Rezarta Frakulli, Andrea Milanoi, Francesco Massari, Maria Ntreta, Giambattista Siepe, Alessandra Arcelli, Silvia Cammelli, Giuseppe Zanirato Rambaldi, Michelangelo Fiorentino, Francesco Deodato (1970) Exceptional response after metronomic chemotherapy and palliative radiotherapy in castration-resistant prostate cancer: A case report. EJMCR, 01 (January 1970): 135-139. doi:10.24911/ejmcr/1/32

Chicago Style

Alessio Giuseppe Morganti, Gabriella Macchia, Rezarta Frakulli, Andrea Milanoi, Francesco Massari, Maria Ntreta, Giambattista Siepe, Alessandra Arcelli, Silvia Cammelli, Giuseppe Zanirato Rambaldi, Michelangelo Fiorentino, Francesco Deodato. "Exceptional response after metronomic chemotherapy and palliative radiotherapy in castration-resistant prostate cancer: A case report." 01 (1970), 135-139. doi:10.24911/ejmcr/1/32

MLA (The Modern Language Association) Style

Alessio Giuseppe Morganti, Gabriella Macchia, Rezarta Frakulli, Andrea Milanoi, Francesco Massari, Maria Ntreta, Giambattista Siepe, Alessandra Arcelli, Silvia Cammelli, Giuseppe Zanirato Rambaldi, Michelangelo Fiorentino, Francesco Deodato. "Exceptional response after metronomic chemotherapy and palliative radiotherapy in castration-resistant prostate cancer: A case report." 01.January 1970 (1970), 135-139. Print. doi:10.24911/ejmcr/1/32

APA (American Psychological Association) Style

Alessio Giuseppe Morganti, Gabriella Macchia, Rezarta Frakulli, Andrea Milanoi, Francesco Massari, Maria Ntreta, Giambattista Siepe, Alessandra Arcelli, Silvia Cammelli, Giuseppe Zanirato Rambaldi, Michelangelo Fiorentino, Francesco Deodato (1970) Exceptional response after metronomic chemotherapy and palliative radiotherapy in castration-resistant prostate cancer: A case report. , 01 (January 1970), 135-139. doi:10.24911/ejmcr/1/32