Case Report
Published: Oct 13, 2025 | DOI: 10.24911/ejmcr.9-2324
Osteochondral fragment repositioning associated with bone marrow aspiration in a patient with knee osteonecrosis following Leukemia treatment: a case report
Authors:
Ivan Alejandro Perez Kalejman
, Mariano Garcia Bistolfi
, Juan Pablo Zícaro
, Carlos Yacuzzi
, Matías Costa-Paz
Article Info
Authors
Ivan Alejandro Perez Kalejman
Department of Trauma and Orthopaedics, Institute Hospital Italiano de Buenos Aires Juan D. Perón 4190 (C1181ACH), Buenos Aires, Argentina
Mariano Garcia Bistolfi
Department of Trauma and Orthopaedics, Institute Hospital Italiano de Buenos Aires Juan D. Perón 4190 (C1181ACH), Buenos Aires, Argentina
Juan Pablo Zícaro
Department of Trauma and Orthopaedics, Institute Hospital Italiano de Buenos Aires Juan D. Perón 4190 (C1181ACH), Buenos Aires, Argentina
Carlos Yacuzzi
Department of Trauma and Orthopaedics, Institute Hospital Italiano de Buenos Aires Juan D. Perón 4190 (C1181ACH), Buenos Aires, Argentina
Matías Costa-Paz
Department of Trauma and Orthopaedics, Institute Hospital Italiano de Buenos Aires Juan D. Perón 4190 (C1181ACH), Buenos Aires, Argentina
Publication History
Received: August 08, 2025
Accepted: September 09, 2025
Published: October 13, 2025
Abstract
Background: Avascular osteonecrosis (AVN) is an idiopathic condition characterised by subchondral ischemia leading to subsequent articular collapse. It can manifest as primary, secondary, or post-surgical. Bone marrow aspirate and concentrate (BMAC) represents a composite of mesenchymal stem cells with robust self-renewal and differentiation capabilities, employed as a surgical adjunct to enhance the healing process.
Case Presentation: Presented herein is a case of a 16-year-old male with a history of acute lymphocytic leukemia and extended corticosteroid therapy, developing AVN in the lateral femoral condyle and concurrent articular cartilage delamination. Arthroscopic repositioning of the chondral fragment was undertaken, complemented by the application of BMAC. Rehabilitation efforts focused on reinstating joint mobility and fostering knee proprioception. At the 1-year postoperative follow-up, the patient reported a pain level of 2/10 on the visual analog scale, an International Knee Documentation Committee score of 88 points, and radiographic evidence indicating consolidation.
Conclusion: The integration of BMAC in knee AVN, coupled with subchondral decompression and chondral fragment repositioning, emerges as a viable treatment option, yielding promising short-term clinical outcomes.
Keywords: BMAC, case report, avascular necrosis, leukemia, osteochondral fragment reposition, bone marrow aspiration
Pubmed Style
Ivan Alejandro Perez Kalejman, Mariano Garcia Bistolfi, Juan Pablo Zícaro, Carlos Yacuzzi, Matías Costa-Paz. Osteochondral fragment repositioning associated with bone marrow aspiration in a patient with knee osteonecrosis following Leukemia treatment: a case report. EJMCR. 2025; 13 (October 2025): -. doi:10.24911/ejmcr.9-2324
Web Style
Ivan Alejandro Perez Kalejman, Mariano Garcia Bistolfi, Juan Pablo Zícaro, Carlos Yacuzzi, Matías Costa-Paz. Osteochondral fragment repositioning associated with bone marrow aspiration in a patient with knee osteonecrosis following Leukemia treatment: a case report. https://ejmcr.com/articles/2324 [Access: October 14, 2025]. doi:10.24911/ejmcr.9-2324
AMA (American Medical Association) Style
Ivan Alejandro Perez Kalejman, Mariano Garcia Bistolfi, Juan Pablo Zícaro, Carlos Yacuzzi, Matías Costa-Paz. Osteochondral fragment repositioning associated with bone marrow aspiration in a patient with knee osteonecrosis following Leukemia treatment: a case report. EJMCR. 2025; 13 (October 2025): -. doi:10.24911/ejmcr.9-2324
Vancouver/ICMJE Style
Ivan Alejandro Perez Kalejman, Mariano Garcia Bistolfi, Juan Pablo Zícaro, Carlos Yacuzzi, Matías Costa-Paz. Osteochondral fragment repositioning associated with bone marrow aspiration in a patient with knee osteonecrosis following Leukemia treatment: a case report. EJMCR. (2025), [cited October 14, 2025]; 13 (October 2025): -. doi:10.24911/ejmcr.9-2324
Harvard Style
Ivan Alejandro Perez Kalejman, Mariano Garcia Bistolfi, Juan Pablo Zícaro, Carlos Yacuzzi, Matías Costa-Paz (2025) Osteochondral fragment repositioning associated with bone marrow aspiration in a patient with knee osteonecrosis following Leukemia treatment: a case report. EJMCR, 13 (October 2025): -. doi:10.24911/ejmcr.9-2324
Chicago Style
Ivan Alejandro Perez Kalejman, Mariano Garcia Bistolfi, Juan Pablo Zícaro, Carlos Yacuzzi, Matías Costa-Paz. "Osteochondral fragment repositioning associated with bone marrow aspiration in a patient with knee osteonecrosis following Leukemia treatment: a case report." 13 (2025), -. doi:10.24911/ejmcr.9-2324
MLA (The Modern Language Association) Style
Ivan Alejandro Perez Kalejman, Mariano Garcia Bistolfi, Juan Pablo Zícaro, Carlos Yacuzzi, Matías Costa-Paz. "Osteochondral fragment repositioning associated with bone marrow aspiration in a patient with knee osteonecrosis following Leukemia treatment: a case report." 13.October 2025 (2025), -. Print. doi:10.24911/ejmcr.9-2324
APA (American Psychological Association) Style
Ivan Alejandro Perez Kalejman, Mariano Garcia Bistolfi, Juan Pablo Zícaro, Carlos Yacuzzi, Matías Costa-Paz (2025) Osteochondral fragment repositioning associated with bone marrow aspiration in a patient with knee osteonecrosis following Leukemia treatment: a case report. , 13 (October 2025), -. doi:10.24911/ejmcr.9-2324