A malignancy phantom: a rare clinical case report of metastatic renal cell carcinoma with no evidence of a primary lesion presenting as cerebellar ataxia
Authors: Husam Farraj, Kamelah Abushalha, Husam Bader, Mitchel F Peabody, Claudia Kroker-Bode
Background: Anti-Ma2 antibody associated paraneoplastic syndrome (PNS) usually presents as limbic encephalitis in the context of testicular tumors. We report a rare case of anti-Ma2 positive PNS with deviation from the classic scenario, thus expanding the phenotype of anti-ma2 associated PNS. Case presentation: This is a 53-year-old male who presented with what was later diagnosed as anti-Ma2 antibody positive cerebellar ataxia. Further workup revealed retroperitoneal lymphadenopathy which, using biopsy, was identified as metastatic clear cell renal cell carcinoma (RCC). However, imaging did not reveal a primary renal lesion. Conclusion: Physicians should be aware of non-classic presentations of paraneoplastic syndromes, especially given that they commonly precede and point towards an underlying, many times undiagnosed, malignancy.
Keywords: Para-neoplastic Syndrome, Renal-cell Carcinoma, Cerebellar Ataxia, Tumor Regression, Case Report.
Authors
Mitchel F Peabody
Department of Hemato-Oncology, Tallahassee Memorial Healthcare, Florida State University School of Medicine, Tallahassee, Florida, USA
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Claudia Kroker-Bode
Department of Internal Medicine, Tallahassee Memorial Healthcare, Florida State University School of Medicine, Tallahassee, Florida, USA.
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Correspondence to:
Husam Farraj, Department of Internal Medicine, Tallahassee Memorial Healthcare, Florida State University School of Medicine, Tallahassee, Florida, USA Husam_farraj@hotmail.com
Publication history:
Received 17 Jul 2023
Accepted 28 Nov 2023
Published in print 13 May 2024
Farraj H, Abushalha K, Bader H, Peabody MF, Kroker-Bode C. A malignancy phantom: a rare clinical case report of metastatic renal cell carcinoma with no evidence of a primary lesion presenting as cerebellar ataxia. EJMCR. 2024; 8(3): 44-46. doi:
10.24911/ejmcr.173-1685921237
Farraj H, Abushalha K, Bader H, Peabody MF, Kroker-Bode C. A malignancy phantom: a rare clinical case report of metastatic renal cell carcinoma with no evidence of a primary lesion presenting as cerebellar ataxia. https://www.ejmcr.com/?mno=155972 [Access: July 03, 2024]. doi:
10.24911/ejmcr.173-1685921237
Farraj H, Abushalha K, Bader H, Peabody MF, Kroker-Bode C. A malignancy phantom: a rare clinical case report of metastatic renal cell carcinoma with no evidence of a primary lesion presenting as cerebellar ataxia. EJMCR. 2024; 8(3): 44-46. doi:
10.24911/ejmcr.173-1685921237
Farraj H, Abushalha K, Bader H, Peabody MF, Kroker-Bode C. A malignancy phantom: a rare clinical case report of metastatic renal cell carcinoma with no evidence of a primary lesion presenting as cerebellar ataxia. EJMCR. (2024), [cited July 03, 2024]; 8(3): 44-46. doi:
10.24911/ejmcr.173-1685921237
Farraj, H., Abushalha, . K., Bader, . H., Peabody, . M. F. & Kroker-Bode, . C. (2024) A malignancy phantom: a rare clinical case report of metastatic renal cell carcinoma with no evidence of a primary lesion presenting as cerebellar ataxia. EJMCR, 8 (3), 44-46. doi:
10.24911/ejmcr.173-1685921237
Farraj, Husam, Kamelah Abushalha, Husam Bader, Mitchel F. Peabody, and Claudia Kroker-Bode. 2024. A malignancy phantom: a rare clinical case report of metastatic renal cell carcinoma with no evidence of a primary lesion presenting as cerebellar ataxia. European Journal of Medical Case Reports, 8 (3), 44-46. doi:
10.24911/ejmcr.173-1685921237
Farraj, Husam, Kamelah Abushalha, Husam Bader, Mitchel F. Peabody, and Claudia Kroker-Bode. "A malignancy phantom: a rare clinical case report of metastatic renal cell carcinoma with no evidence of a primary lesion presenting as cerebellar ataxia." European Journal of Medical Case Reports 8 (2024), 44-46. doi:
10.24911/ejmcr.173-1685921237
Farraj, Husam, Kamelah Abushalha, Husam Bader, Mitchel F. Peabody, and Claudia Kroker-Bode. "A malignancy phantom: a rare clinical case report of metastatic renal cell carcinoma with no evidence of a primary lesion presenting as cerebellar ataxia." European Journal of Medical Case Reports 8.3 (2024), 44-46. Print. doi:
10.24911/ejmcr.173-1685921237
Farraj, H., Abushalha, . K., Bader, . H., Peabody, . M. F. & Kroker-Bode, . C. (2024) A malignancy phantom: a rare clinical case report of metastatic renal cell carcinoma with no evidence of a primary lesion presenting as cerebellar ataxia. European Journal of Medical Case Reports, 8 (3), 44-46. doi:
10.24911/ejmcr.173-1685921237