Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?
Authors: Luis Francisco Pineda Galindo, Zully Esmeralda Contreras Cortes, Andrea Avila Martinez, Maria del Rosario Mora Campos, Elsa Acosta Jimenez, Armando Perez Torres
BACKGROUND: Amyloidosis is a multisystemic disease that may be hereditary, characterized by the deposit of amyloid in the extracellular space [1,4]. Transthyretin-mediated (ATTRm) amyloidosis is the most common subtype of heredofamilial amyloidosis [5]. The diagnosis is based on clinical suspicion and demonstration. of amyloid in tissues [7]. Hepatic transplantation (HT) is the only treatment that prevents the synthesis of the amyloidogenic variants of TTR [16]. CASE PRESENTATION: A 34-year-old male who presented with weight loss, gastrointestinal symptomatology and polyneuropathy associated with histopathologic deposits of amyloid in gastrointestinal and fat tissue as well as peripheral nerve. CONCLUSION: Hereditary familial amyloidosis (HFA) is a relatively rare disorder which leads to erroneous and delayed definitive diagnosis. Therefore, the diagnosis should be first based on a suspicion of the disease, and then proceed with the according complete protocol.
Keywords: Amyloidosis, poluneuropathy, Trasnthyretin, Diagnosis, Biopsy.
Authors
Correspondence to:
Zully Esmeralda Contreras Cortés, Department of Internal Medicine, Specialties Hospital National Medical Center La Raza, IMSS, Mexico City zullyecc1009@gmail.com
Publication history:
Received 14 May 2023
Revised 19 Dec 2023
Accepted 10 Feb 2024
Galindo LFP, Cortes ZEC, Martinez AA, Campos MdRM, Jimenez EA, Torres AP. Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?. doi:
10.24911/ejmcr.173-1660235974
Galindo LFP, Cortes ZEC, Martinez AA, Campos MdRM, Jimenez EA, Torres AP. Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?. https://www.ejmcr.com/?mno=102679 [Access: July 03, 2024]. doi:
10.24911/ejmcr.173-1660235974
Galindo LFP, Cortes ZEC, Martinez AA, Campos MdRM, Jimenez EA, Torres AP. Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?. doi:
10.24911/ejmcr.173-1660235974
Galindo LFP, Cortes ZEC, Martinez AA, Campos MdRM, Jimenez EA, Torres AP. Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?. doi:
10.24911/ejmcr.173-1660235974
Galindo, L. F. P., Cortes, . Z. E. C., Martinez, . A. A., Campos, . M. d. R. M., Jimenez, . E. A. & Torres, . A. P. (2024) Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?. doi:
10.24911/ejmcr.173-1660235974
Galindo, Luis Francisco Pineda, Zully Esmeralda Contreras Cortes, Andrea Avila Martinez, Maria del Rosario Mora Campos, Elsa Acosta Jimenez, and Armando Perez Torres. 2024. Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?. doi:
10.24911/ejmcr.173-1660235974
Galindo, Luis Francisco Pineda, Zully Esmeralda Contreras Cortes, Andrea Avila Martinez, Maria del Rosario Mora Campos, Elsa Acosta Jimenez, and Armando Perez Torres. "Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?." doi:
10.24911/ejmcr.173-1660235974
Galindo, Luis Francisco Pineda, Zully Esmeralda Contreras Cortes, Andrea Avila Martinez, Maria del Rosario Mora Campos, Elsa Acosta Jimenez, and Armando Perez Torres. "Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?." doi:
10.24911/ejmcr.173-1660235974
Galindo, L. F. P., Cortes, . Z. E. C., Martinez, . A. A., Campos, . M. d. R. M., Jimenez, . E. A. & Torres, . A. P. (2024) Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?. doi:
10.24911/ejmcr.173-1660235974