Case report of an unusual manifestation of anti-GBM disease
Authors: John Swayne, Ritienne Debono, Maria Bonello
Background: Anti-GBM disease is a small vessel vasculitis that occurs when circulating antibodies against the glomerular basement membrane develop. It is a relatively rare disease, occurring in less than two cases per million population. The usual presentation is with renal or lung manifestations or with a combination of both. Case Presentation: Our case reports a patient who presented with end-stage renal disease secondary to anti-GBM disease, with no pulmonary manifestations, who later presented with a syndrome suggesting cerebral vasculitis, that responded to immunosuppressive treatment. Conclusion: Cerebral involvement in anti-GBM disease is very rare and to our knowledge, only a few cases have been so far reported.
Keywords: Anti-GBM disease, cerebral vasculitis, immunosuppression, small vessel vasculitis.
Authors
Correspondence to:
John Swayne, Department of Medicine, Division of Nephrology, Mater Dei Hospital, San Gwann, Malta john.b.swayne@gov.mt
Publication history:
Received 27 Aug 2022
Revised 28 Nov 2022
Accepted 30 Nov 2022
Published online 22 Dec 2022
Published in print 29 Dec 2022
Swayne J, Debono R, Bonello M. Case report of an unusual manifestation of anti-GBM disease. EJMCR. 2022; 6(9): 169-172. doi:
10.24911/ejmcr/173-1660205558
Swayne J, Debono R, Bonello M. Case report of an unusual manifestation of anti-GBM disease. https://www.ejmcr.com/?mno=102394 [Access: May 09, 2024]. doi:
10.24911/ejmcr/173-1660205558
Swayne J, Debono R, Bonello M. Case report of an unusual manifestation of anti-GBM disease. EJMCR. 2022; 6(9): 169-172. doi:
10.24911/ejmcr/173-1660205558
Swayne J, Debono R, Bonello M. Case report of an unusual manifestation of anti-GBM disease. EJMCR. (2022), [cited May 09, 2024]; 6(9): 169-172. doi:
10.24911/ejmcr/173-1660205558
Swayne, J., Debono, . R. & Bonello, . M. (2022) Case report of an unusual manifestation of anti-GBM disease. EJMCR, 6 (9), 169-172. doi:
10.24911/ejmcr/173-1660205558
Swayne, John, Ritienne Debono, and Maria Bonello. 2022. Case report of an unusual manifestation of anti-GBM disease. European Journal of Medical Case Reports, 6 (9), 169-172. doi:
10.24911/ejmcr/173-1660205558
Swayne, John, Ritienne Debono, and Maria Bonello. "Case report of an unusual manifestation of anti-GBM disease." European Journal of Medical Case Reports 6 (2022), 169-172. doi:
10.24911/ejmcr/173-1660205558
Swayne, John, Ritienne Debono, and Maria Bonello. "Case report of an unusual manifestation of anti-GBM disease." European Journal of Medical Case Reports 6.9 (2022), 169-172. Print. doi:
10.24911/ejmcr/173-1660205558
Swayne, J., Debono, . R. & Bonello, . M. (2022) Case report of an unusual manifestation of anti-GBM disease. European Journal of Medical Case Reports, 6 (9), 169-172. doi:
10.24911/ejmcr/173-1660205558