EJMCR. 2017; 1(May 2017): 86-91

Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report

Authors: Amybel Belladonna Taylor, May Lynn Yeap, Peta Sharples, Mohamed Osman Eltahir Babiker.

ABSTRACT

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome manifests as a significant, medication-induced, adverse reaction with cutaneous, hematological and multi-organ involvement. Sero-negative autoimmune encephalitis is inflammation of the brain secondary to autoimmune processes in the absence of an identifiable autoantibody. Case presentation: We present a pediatric case of sero-negative autoimmune encephalitis who subsequently developed DRESS syndrome as a result of exposure to ceftriaxone, omeprazole or acyclovir. She did not respond to either high-dose steroids or intravenous immunoglobulins (IVIG). Plasmapheresis was successful in treating symptoms relevant to both DRESS and sero-negative autoimmune encephalitis. No side effects were encountered. Conclusion: To our knowledge, plasmapheresis has only been reported once to treat DRESS syndrome in a pediatric patient. Early recognition and treatment of this syndrome is paramount. We suggest that plasmapheresis is a relatively safe alternative treatment option for resistant cases especially within the context of other autoimmune conditions.

Keywords:
Plasmapharesis, DRESS syndrome, ceftriaxone, omeprazole, aciclovir, sero--negative autoimmune encephalitis, case report


View PDF
Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report


Authors
Amybel Belladonna Taylor
Department of Paediatric Neurology, Bristol Royal Hospital for Children, Bristol, UK
PubMed articlesGoogle scholar articles

May Lynn Yeap
Department of Paediatric Neurology, Bristol Royal Hospital for Children, Bristol, UK
PubMed articlesGoogle scholar articles

Peta Sharples
Department of Paediatric Neurology, Bristol Royal Hospital for Children, Bristol, UK
PubMed articlesGoogle scholar articles

Mohamed Osman Eltahir Babiker
Faculty of Medicine, University of Bristol, Bristol, UK.
PubMed articlesGoogle scholar articles


Correspondence to:
Amybel Belladonna Taylor. Amybel Belladonna Taylor, Faculty of Medicine, University of Bristol, Bristol, UK.; amybeltaylor@mac.com

Publication history
Received 15 Apr 2017
Accepted 10 May 2017

How to cite this article?

Export to EndNote Export to refMan

Pubmed Style

Taylor AB, Yeap ML, Sharples P, Babiker MOE. Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report. EJMCR. 2017; 1(May 2017): 86-91. doi:10.24911/ejmcr/1/21


Web Style

Taylor AB, Yeap ML, Sharples P, Babiker MOE. Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report. http://www.ejmcr.com/?mno=264181 [Access: September 24, 2018]. doi:10.24911/ejmcr/1/21


AMA (American Medical Association) Style

Taylor AB, Yeap ML, Sharples P, Babiker MOE. Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report. EJMCR. 2017; 1(May 2017): 86-91. doi:10.24911/ejmcr/1/21


Vancouver/ICMJE Style

Taylor AB, Yeap ML, Sharples P, Babiker MOE. Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report. EJMCR. (2017), [cited September 24, 2018]; 1(May 2017): 86-91. doi:10.24911/ejmcr/1/21


Harvard Style

Taylor, A. B., Yeap, M. L., Sharples, P. & Babiker, M. O. E. (2017) Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report. EJMCR, 1 (May 2017), 86-91. doi:10.24911/ejmcr/1/21


Turabian Style

Taylor, Amybel Belladonna, May Lynn Yeap, Peta Sharples, and Mohamed Osman Eltahir Babiker. 2017. Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report. European Journal of Medical Case Reports, 1 (May 2017), 86-91. doi:10.24911/ejmcr/1/21


Chicago Style

Taylor, Amybel Belladonna, May Lynn Yeap, Peta Sharples, and Mohamed Osman Eltahir Babiker. "Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report." European Journal of Medical Case Reports 1 (2017), 86-91. doi:10.24911/ejmcr/1/21


MLA (The Modern Language Association) Style

Taylor, Amybel Belladonna, May Lynn Yeap, Peta Sharples, and Mohamed Osman Eltahir Babiker. "Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report." European Journal of Medical Case Reports 1.May 2017 (2017), 86-91. Print. doi:10.24911/ejmcr/1/21


APA (American Psychological Association) Style

Taylor, A. B., Yeap, M. L., Sharples, P. & Babiker, M. O. E. (2017) Successful treatment of DRESS syndrome with plasmapheresis during the course of sero-negative autoimmune encephalitis: a case report. European Journal of Medical Case Reports, 1 (May 2017), 86-91. doi:10.24911/ejmcr/1/21


Share this article

Click the icon of the social media platform on which you would like to share this article.

Article Statistics

Viewed: 3957
Downloaded: 309
Cited: 1

Request permissions

If you wish to reuse any part or all of this article please contact the copyright holder, contact@ejmcr.com.

Copyright © 2018 Discover Publishing Group. All Rights Reserved.