Authors: Dr Daiki Yokokawa , Dr Takanori Uehara , Dr Yoshiyuki Ohira , Dr Kazutaka Noda , Dr Masatomi Ikusaka

Abstract

Background: Drug fever can complicate the diagnosis of recurrent fever, especially when multiple physicians are involved in treatment.

Case Presentation: We report the case of a 56-year-old man with recurrent fever responsive to antibiotics, initially suggesting a persistent bacterial infection. Detailed history-taking revealed that he discontinued minocycline, prescribed for rosacea dermatitis, when starting new antibiotics, and resumed it after the fever subsided. Eosinophilia and a clear improvement in the general condition between fevers led to the suspicion of drug fever. A rechallenge confirmed minocycline-induced fever.

Conclusion: This case emphasizes the importance of thoroughly reviewing medication history and patients’ medication-taking behavior when drug fever is suspected. 

Keywords: Minocycline, Drug fever, Medication-taking behavior