Case Report
Volume: 4 | Issue: 9 | Published: Oct 06, 2020 | Pages: 280 - 284 | DOI: 10.24911/ejmcr/173-1554056047
Case report of intrahepatic cholangiocarcinoma showing thyroid like follicular pattern: a rare morphological variant
Authors: Ashini Shah , Brinda S. Chandibhamar , Amisha Gami , Priti Trivedi
Article Info
Authors
Ashini Shah
Department of Oncopathology, Gujarat Cancer Research Institute, Civil Hospital, Ahmedabad, India
Brinda S. Chandibhamar
Department of Oncopathology, Gujarat Cancer Research Institute, Civil Hospital, Ahmedabad, India
Amisha Gami
Department of Oncopathology, Gujarat Cancer Research Institute, Civil Hospital, Ahmedabad, India
Priti Trivedi
Department of Oncopathology, Gujarat Cancer Research Institute, Civil Hospital, Ahmedabad, India
Publication History
Received: April 07, 2019
Revised: July 13, 2020
Accepted: September 03, 2020
Published: October 06, 2020
Abstract
Background: Intrahepatic cholangiocarcinoma (ICC) is arising from the intrahepatic bile ducts and accounts for 8%-10% of all malignant hepatic tumors. Case Presentation: We report the case of a 42-year-old woman having ICC with thyroid-like follicular pattern. The patient had 9-cm solitary liver mass showing morphological pattern resembling thyroid follicles. Immunohistochemistry was negative for thyroid markers. The patient had no evidence of a previous or concomitant thyroid tumor. This case can be added to the list of extrathyroidal primary tumor that morphologically resembles thyroid neoplasms. Only three such cases have been previously reported in the literature. Such a pattern is known to occur in primary kidney and breast tumor. Thyroid like pattern broadens the morphological spectrum of cholangiocarcinoma. Conclusion: Careful evaluation of this morphological rare variant of ICC is very essential to prevent misdiagnosis of metastatic thyroid follicular neoplasm.
Keywords: Cholangiocarcinoma, thyroid follicle-like pattern, thyroid transcription factor 1 (TTF-1), green
