Case Report
Volume: 7 | Issue: 4 | Published: Mar 28, 2023 | Pages: 83 - 88 | DOI: 10.24911/ejmcr/173-1656697695
Two case reports of sudden cardiac arrest with unsuccessful resuscitation: is there a role for postmortem investigation and targeted next generation sequencing?
Authors:
Maaike Ramael
, Hilde Van Steelandt
, Marc Ramael
Article Info
Authors
Maaike Ramael
Faculty of medical and health sciences, University of Antwerp, Antwerpen, Belgium
Hilde Van Steelandt
Department of molecular imaging, AZ Herentals, Herentals, Belgium
Marc Ramael
Laboratory of histology and cell biology University of Antwerp, Antwerpen, Belgium.
Publication History
Received: July 04, 2022
Accepted:
Published: March 28, 2023
Abstract
Background: Sudden unexpected cardiac arrest is one of the life-threatening interventions of the pre hospital emergency medicine teams. Globally sudden cardiac death (SCD) accounts for 4-5 million deaths per year and is in most cases linked to coronary artery disease. Other causes include cardiomyopathies and channelopathies, but these are not always clear to the physician. Case Presentation: We present two unconscious patients with life-threatening cardiac arrests who were unsuccessfully resuscitated by the emergency team. As the cause of the sudden cardiac arrest was unclear an autopsy was performed. Conclusion: SCD can be the final stage of several pathologies. In acute myocardial infarction due to coronary artery disease, the underlying cause is clear. The situation is however more complex in drug abuse where the physician should be aware that underlying pathologies can be masked. If the cause of sudden cardiac arrest is unclear, a "molecular" autopsy is recommended to detect genetic susceptibility to dysrhythmias( long QT syndrome, Brugada syndrome), cardiomyopathies, thoracic aortic aneurysm, and dissection. Correlating significant clinical information, postmortem findings and genetic analysis can be used to detect underlying pathologies and to decide whether genetic screening and clinical follow up of relatives should be carried out.
Keywords: Autopsy, Cardiomyopathy, Abuse drug, Genetic susceptibility, Thoracic aortic dissection, Case report, green
Pubmed Style
Maaike Ramael, Hilde Van Steelandt, Marc Ramael. Two case reports of sudden cardiac arrest with unsuccessful resuscitation: is there a role for postmortem investigation and targeted next generation sequencing?. EJMCR. 2023; 28 (March 2023): 83-88. doi:10.24911/ejmcr/173-1656697695
Web Style
Maaike Ramael, Hilde Van Steelandt, Marc Ramael. Two case reports of sudden cardiac arrest with unsuccessful resuscitation: is there a role for postmortem investigation and targeted next generation sequencing?. https://ejmcr.com/articles/1065 [Access: December 25, 2024]. doi:10.24911/ejmcr/173-1656697695
AMA (American Medical Association) Style
Maaike Ramael, Hilde Van Steelandt, Marc Ramael. Two case reports of sudden cardiac arrest with unsuccessful resuscitation: is there a role for postmortem investigation and targeted next generation sequencing?. EJMCR. 2023; 28 (March 2023): 83-88. doi:10.24911/ejmcr/173-1656697695
Vancouver/ICMJE Style
Maaike Ramael, Hilde Van Steelandt, Marc Ramael. Two case reports of sudden cardiac arrest with unsuccessful resuscitation: is there a role for postmortem investigation and targeted next generation sequencing?. EJMCR. (2023), [cited December 25, 2024]; 28 (March 2023): 83-88. doi:10.24911/ejmcr/173-1656697695
Harvard Style
Maaike Ramael, Hilde Van Steelandt, Marc Ramael (2023) Two case reports of sudden cardiac arrest with unsuccessful resuscitation: is there a role for postmortem investigation and targeted next generation sequencing?. EJMCR, 28 (March 2023): 83-88. doi:10.24911/ejmcr/173-1656697695
Chicago Style
Maaike Ramael, Hilde Van Steelandt, Marc Ramael. "Two case reports of sudden cardiac arrest with unsuccessful resuscitation: is there a role for postmortem investigation and targeted next generation sequencing?." 28 (2023), 83-88. doi:10.24911/ejmcr/173-1656697695
MLA (The Modern Language Association) Style
Maaike Ramael, Hilde Van Steelandt, Marc Ramael. "Two case reports of sudden cardiac arrest with unsuccessful resuscitation: is there a role for postmortem investigation and targeted next generation sequencing?." 28.March 2023 (2023), 83-88. Print. doi:10.24911/ejmcr/173-1656697695
APA (American Psychological Association) Style
Maaike Ramael, Hilde Van Steelandt, Marc Ramael (2023) Two case reports of sudden cardiac arrest with unsuccessful resuscitation: is there a role for postmortem investigation and targeted next generation sequencing?. , 28 (March 2023), 83-88. doi:10.24911/ejmcr/173-1656697695