EJMCR |

Case Report

Volume: 6 | Issue: 6 | Published: Sep 12, 2022 | Pages: 111 - 115 | DOI: 10.24911/ejmcr/173-1653153200

A unique case of Lemierre's Syndrome and cerebral vein thrombosis in a carrier of prothrombin gene G20210A mutation

Authors: Matteo Doneddu , Francesco Marongiu

Article Info

Authors

Matteo Doneddu

Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy

ORCID

Francesco Marongiu

Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

Publication History

Received: May 22, 2022

Revised: August 01, 2022

Accepted: August 01, 2022

Published: September 12, 2022

Abstract

Introduction: We describe here a case of a woman admitted to our Internal Medicine Unit for multifocal pneumonia. During the stay, she presented a few neurological symptoms: headache, nausea, emesis, photophobia, and gait disturbance. Methodology: Chest computed tomography (CT) detected multiple areas interpreted as septic emboli. Moreover, a left internal jugular thrombosis (LIJT) was incidentally reported. A CT-angiography showed the LIJT extension to cerebral sinuses. Ear, nose, and throat consultation revealed a left medium otitis. Anticoagulation with Fondaparinux was associated to antibiotic therapy with improvement in neurological symptoms that totally remitted over the next 2 weeks. Results: These findings confirmed the diagnosis of a Lemierre's Syndrome with thrombosis extension to cerebral sinuses. The genetic thrombophilic panel showed a heterozygosis for prothrombin gene G20210A mutation and the patient was discharged with Rivaroxaban for home continuation of anticoagulant therapy for at least 6 months. Conclusion: The prevalence of inherited thrombophilias in Lemierre's Syndrome is unknown and to our knowledge, this article is the first to identify a prothrombin gene G20210A mutation in a patient with Lemierre's Syndrome with thrombosis extension into the cerebral venous system. Exploring patients with Lemierre's Syndrome for underlying thrombophilia could clarify whether this promotes retrograde jugular vein thrombosis extension.

Keywords: Case report, Lemierre's Syndrome, thrombophilia, cerebral vein thrombosis, DOACs, green

Pubmed Style

Matteo Doneddu, Francesco Marongiu. A unique case of Lemierre's Syndrome and cerebral vein thrombosis in a carrier of prothrombin gene G20210A mutation. EJMCR. 2022; 12 (September 2022): 111-115. doi:10.24911/ejmcr/173-1653153200

Web Style

Matteo Doneddu, Francesco Marongiu. A unique case of Lemierre's Syndrome and cerebral vein thrombosis in a carrier of prothrombin gene G20210A mutation. https://ejmcr.com/articles/1095 [Access: December 04, 2024]. doi:10.24911/ejmcr/173-1653153200

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Matteo Doneddu, Francesco Marongiu. A unique case of Lemierre's Syndrome and cerebral vein thrombosis in a carrier of prothrombin gene G20210A mutation. EJMCR. (2022), [cited December 04, 2024]; 12 (September 2022): 111-115. doi:10.24911/ejmcr/173-1653153200

Harvard Style

Matteo Doneddu, Francesco Marongiu (2022) A unique case of Lemierre's Syndrome and cerebral vein thrombosis in a carrier of prothrombin gene G20210A mutation. EJMCR, 12 (September 2022): 111-115. doi:10.24911/ejmcr/173-1653153200

Chicago Style

Matteo Doneddu, Francesco Marongiu. "A unique case of Lemierre's Syndrome and cerebral vein thrombosis in a carrier of prothrombin gene G20210A mutation." 12 (2022), 111-115. doi:10.24911/ejmcr/173-1653153200

MLA (The Modern Language Association) Style

Matteo Doneddu, Francesco Marongiu. "A unique case of Lemierre's Syndrome and cerebral vein thrombosis in a carrier of prothrombin gene G20210A mutation." 12.September 2022 (2022), 111-115. Print. doi:10.24911/ejmcr/173-1653153200

APA (American Psychological Association) Style

Matteo Doneddu, Francesco Marongiu (2022) A unique case of Lemierre's Syndrome and cerebral vein thrombosis in a carrier of prothrombin gene G20210A mutation. , 12 (September 2022), 111-115. doi:10.24911/ejmcr/173-1653153200