Case Report
Volume: 6 | Issue: 6 | Published: Sep 12, 2022 | Pages: 91 - 94 | DOI: 10.24911/ejmcr/173-1638536657
Plasma cell myeloma - a unique case presenting as thyroid plasmacytoma and mimicking of medullary carcinoma: how to avoid pitfall in aspiration cytology
Authors:
Sinem Kantarcioglu Coskun
, Asli Naldemir
, Mehmet Gamsizkan
, Binnur Onal
Article Info
Authors
Sinem Kantarcioglu Coskun
Department of Pathology & Cytology, School of Medicine, Duzce University, Konuralp Campus, Turkey
Asli Naldemir
Department of Pathology & Cytology, School of Medicine, Duzce University, Konuralp Campus, Turkey
Mehmet Gamsizkan
Department of Pathology & Cytology, School of Medicine, Duzce University, Konuralp Campus, Turkey
Binnur Onal
Department of Pathology & Cytology, School of Medicine, Duzce University, Konuralp Campus, Turkey.
Publication History
Received: April 12, 2022
Revised: August 09, 2022
Accepted: August 09, 2022
Published: September 12, 2022
Abstract
Background: Extramedullary plasmacytoma (EMP) of the thyroid is a rare neoplasm that may present either as a solitary plasmacell tumor or involvement of plasma cell myeloma (PCM). In this report, we present a unique case of PCM presented as a thyroid mass without previous history, and initially misinterpreted as medullary carcinoma on fine-needle aspiration cytology (FNAC). Case Presentation: A 77-year-old female presented with shortness of breath and palpitation. Ultrasonography-guided FNAC from the large thyroid mass revealed hypercellular smears composed of monomorphic plasmacytoid cells, focally binucleated, scattered diffusely. Subsequent histopathological examination and immunohistochemistry of thyroidectomy specimen showed infiltration of sheets of plasma cells and diagnosed as EMP. Histology of the bone marrow displayed Lambda positive neoplastic plasma cells. A combination of singly distributed cells and aggregates with plasmacytoid morphology on a proteinous background without clinical suspicion and previous history leads to misinterpretation of FNAC. Conclusion: Clinical correlation, immunocytochemistry, and complementary cytological approach including various preparation techniques of staining are crucial for avoiding diagnostic pitfalls and the patients' proper treatment.
Keywords: Plasma cell myeloma, case report, thyroid, cytology, medullary carcinoma, FNAC, green
Pubmed Style
Sinem Kantarcioglu Coskun, Asli Naldemir, Mehmet Gamsizkan, Binnur Onal. Plasma cell myeloma - a unique case presenting as thyroid plasmacytoma and mimicking of medullary carcinoma: how to avoid pitfall in aspiration cytology. EJMCR. 2022; 12 (September 2022): 91-94. doi:10.24911/ejmcr/173-1638536657
Web Style
Sinem Kantarcioglu Coskun, Asli Naldemir, Mehmet Gamsizkan, Binnur Onal. Plasma cell myeloma - a unique case presenting as thyroid plasmacytoma and mimicking of medullary carcinoma: how to avoid pitfall in aspiration cytology. https://ejmcr.com/articles/1091 [Access: December 04, 2024]. doi:10.24911/ejmcr/173-1638536657
AMA (American Medical Association) Style
Sinem Kantarcioglu Coskun, Asli Naldemir, Mehmet Gamsizkan, Binnur Onal. Plasma cell myeloma - a unique case presenting as thyroid plasmacytoma and mimicking of medullary carcinoma: how to avoid pitfall in aspiration cytology. EJMCR. 2022; 12 (September 2022): 91-94. doi:10.24911/ejmcr/173-1638536657
Vancouver/ICMJE Style
Sinem Kantarcioglu Coskun, Asli Naldemir, Mehmet Gamsizkan, Binnur Onal. Plasma cell myeloma - a unique case presenting as thyroid plasmacytoma and mimicking of medullary carcinoma: how to avoid pitfall in aspiration cytology. EJMCR. (2022), [cited December 04, 2024]; 12 (September 2022): 91-94. doi:10.24911/ejmcr/173-1638536657
Harvard Style
Sinem Kantarcioglu Coskun, Asli Naldemir, Mehmet Gamsizkan, Binnur Onal (2022) Plasma cell myeloma - a unique case presenting as thyroid plasmacytoma and mimicking of medullary carcinoma: how to avoid pitfall in aspiration cytology. EJMCR, 12 (September 2022): 91-94. doi:10.24911/ejmcr/173-1638536657
Chicago Style
Sinem Kantarcioglu Coskun, Asli Naldemir, Mehmet Gamsizkan, Binnur Onal. "Plasma cell myeloma - a unique case presenting as thyroid plasmacytoma and mimicking of medullary carcinoma: how to avoid pitfall in aspiration cytology." 12 (2022), 91-94. doi:10.24911/ejmcr/173-1638536657
MLA (The Modern Language Association) Style
Sinem Kantarcioglu Coskun, Asli Naldemir, Mehmet Gamsizkan, Binnur Onal. "Plasma cell myeloma - a unique case presenting as thyroid plasmacytoma and mimicking of medullary carcinoma: how to avoid pitfall in aspiration cytology." 12.September 2022 (2022), 91-94. Print. doi:10.24911/ejmcr/173-1638536657
APA (American Psychological Association) Style
Sinem Kantarcioglu Coskun, Asli Naldemir, Mehmet Gamsizkan, Binnur Onal (2022) Plasma cell myeloma - a unique case presenting as thyroid plasmacytoma and mimicking of medullary carcinoma: how to avoid pitfall in aspiration cytology. , 12 (September 2022), 91-94. doi:10.24911/ejmcr/173-1638536657