EJMCR |

Case Report

Volume: 5 | Issue: 9 | Published: Oct 03, 2021 | Pages: 270 - 273 | DOI: 10.24911/ejmcr/173-1617741385

Anxiety and depression in tyrosine hydroxylase deficiency: a case report

Authors: Belen Garcia Alarcon , Mark Walterfang , Wesley Thevathasan

Article Info

Authors

Belen Garcia Alarcon

Benito Menni Hospital, Adults Mental Health Centre, Sant Boi, Spain

Mark Walterfang

Royal Melbourne Hospital, Department of neuropsychiatry, Melbourne, Australia

Wesley Thevathasan

Melbourne Brain Centre, Department of Medicine, University of Melbourne, Australia.

Publication History

Received: April 06, 2021

Revised: September 07, 2021

Accepted: September 07, 2021

Published: October 03, 2021

Abstract

Background: Tyrosine hydroxylase (TH) deficiency is a very rare genetic disorder of monoamine synthesis which alongside Guanosine triphosphate (GTP) cyclohydrolase deficiency - is one of the metabolic dopa-responsive dystonias. These disorders classically present as a dystonia with onset in adolescence which is non-progressive and responds to standard dopaminergic treatment: however, little is known about the relationship between TH deficiency and psychiatric illness. Case Presentation: We describe a case of a young woman who, in the absence of any heralding psychiatric symptomatology of any nature, developed a severe and limiting panic disorder at around the time of onset of her movement disorder in the setting of TH deficiency, which impacts dopamine synthesis. Conclusion: Neurometabolic disorders that affect neurotransmitter function frequently present with psychiatric symptomatology and can provide models for understanding some frequently presenting psychiatric illnesses such as depression and anxiety. We discuss the interplay between the dopaminergic and serotonergic systems, and how an ostensibly dopaminergic disorder could produce what has long been understood to be a serotonergically-driven anxiety syndrome.

Keywords: Tyrosine hydroxylase, anxiety, panic disorder, depression, case report, green

Pubmed Style

Belen Garcia Alarcon, Mark Walterfang, Wesley Thevathasan. Anxiety and depression in tyrosine hydroxylase deficiency: a case report. EJMCR. 2021; 03 (October 2021): 270-273. doi:10.24911/ejmcr/173-1617741385

Web Style

Belen Garcia Alarcon, Mark Walterfang, Wesley Thevathasan. Anxiety and depression in tyrosine hydroxylase deficiency: a case report. https://ejmcr.com/articles/1123 [Access: December 03, 2024]. doi:10.24911/ejmcr/173-1617741385

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Belen Garcia Alarcon, Mark Walterfang, Wesley Thevathasan. Anxiety and depression in tyrosine hydroxylase deficiency: a case report. EJMCR. (2021), [cited December 03, 2024]; 03 (October 2021): 270-273. doi:10.24911/ejmcr/173-1617741385

Harvard Style

Belen Garcia Alarcon, Mark Walterfang, Wesley Thevathasan (2021) Anxiety and depression in tyrosine hydroxylase deficiency: a case report. EJMCR, 03 (October 2021): 270-273. doi:10.24911/ejmcr/173-1617741385

Chicago Style

Belen Garcia Alarcon, Mark Walterfang, Wesley Thevathasan. "Anxiety and depression in tyrosine hydroxylase deficiency: a case report." 03 (2021), 270-273. doi:10.24911/ejmcr/173-1617741385

MLA (The Modern Language Association) Style

Belen Garcia Alarcon, Mark Walterfang, Wesley Thevathasan. "Anxiety and depression in tyrosine hydroxylase deficiency: a case report." 03.October 2021 (2021), 270-273. Print. doi:10.24911/ejmcr/173-1617741385

APA (American Psychological Association) Style

Belen Garcia Alarcon, Mark Walterfang, Wesley Thevathasan (2021) Anxiety and depression in tyrosine hydroxylase deficiency: a case report. , 03 (October 2021), 270-273. doi:10.24911/ejmcr/173-1617741385