Case Report
Volume: 5 | Issue: 7 | Published: Jul 13, 2021 | Pages: 218 - 221 | DOI: 10.24911/ejmcr/173-1613255228
Adult-onset Still's disease possibly consequent to asymptomatic COVID-19
Authors: Paula Ibanez , Angel Manuel Iniesta , Angel Robles , Mariana Gutierrez , Francisco Bermudez , Juan Carlos Martin
Article Info
Authors
Paula Ibanez
Servicio de medicina interna, Hospital universitario La Paz, Paseo de la Castellana, n&#8304
Angel Manuel Iniesta
261, 28046 Madrid, Spain
Angel Robles
Servicio de cardiología, Hospital universitario La Paz, Paseo de la Castellana, n&#8304
Mariana Gutierrez
261, 28046 Madrid, Spain
Francisco Bermudez
Unidad de enfermedades autoinmunes, servicio de medicina interna, Hospital universitario La Paz, Paseo de la Castellana, n&#8304
Juan Carlos Martin
261, 28046 Madrid, Spain
Publication History
Received: February 14, 2021
Accepted: June 26, 2021
Published: July 13, 2021
Abstract
Background: In some patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019 [COVID-19]), an uncontrolled release of inflammatory cytokines is characteristic. COVID-19 and adult-onset Stills disease (AOSD) have been included by some authors in the hyperferritinemic syndromes. Another hyperinflammatory syndrome (with variable features of Kawasaki disease) called multisystem inflammatory syndrome (MIS) has been described in patients who have had SARS-CoV-2 infection. Case Presentation: We present a previously healthy patient who developed hyperinflammatory reaction compatible with MIS; the clinical presentation is additionally compatible with AOSD, complicated with a mild myocarditis. The patient had a positive SARS-CoV-2 serology (immunoglobulins G and immunoglobulins M ), but multiple reverse transcription-polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 on nasopharyngeal swab were negative or indeterminate, so we considered that it is possible that an asymptomatic SARS-CoV-2 infection could have been the trigger for Stills disease. 24 hours after starting methylprednisolone treatment, the fever was resolved and symptoms improved over the next few days, with persistent arthralgias. Conclusion: Asymptomatic SARS-CoV-2 infection could trigger MIS with AOSD-like features.
Keywords: SARS-CoV-2, COVID-19, adult-onset Stills disease (AOSD), myocarditis, hyperferritinemic syndromes, multisystem inflammatory syndrome (MIS), multisystem inflammatory syndrome of children (MIS-C), case report, green
Pubmed Style
Paula Ibanez, Angel Manuel Iniesta, Angel Robles, Mariana Gutierrez, Francisco Bermudez, Juan Carlos Martin. Adult-onset Still's disease possibly consequent to asymptomatic COVID-19. EJMCR. 2021; 13 (July 2021): 218-221. doi:10.24911/ejmcr/173-1613255228
Web Style
Paula Ibanez, Angel Manuel Iniesta, Angel Robles, Mariana Gutierrez, Francisco Bermudez, Juan Carlos Martin. Adult-onset Still's disease possibly consequent to asymptomatic COVID-19. https://ejmcr.com/articles/1306 [Access: December 25, 2024]. doi:10.24911/ejmcr/173-1613255228
AMA (American Medical Association) Style
Paula Ibanez, Angel Manuel Iniesta, Angel Robles, Mariana Gutierrez, Francisco Bermudez, Juan Carlos Martin. Adult-onset Still's disease possibly consequent to asymptomatic COVID-19. EJMCR. 2021; 13 (July 2021): 218-221. doi:10.24911/ejmcr/173-1613255228
Vancouver/ICMJE Style
Paula Ibanez, Angel Manuel Iniesta, Angel Robles, Mariana Gutierrez, Francisco Bermudez, Juan Carlos Martin. Adult-onset Still's disease possibly consequent to asymptomatic COVID-19. EJMCR. (2021), [cited December 25, 2024]; 13 (July 2021): 218-221. doi:10.24911/ejmcr/173-1613255228
Harvard Style
Paula Ibanez, Angel Manuel Iniesta, Angel Robles, Mariana Gutierrez, Francisco Bermudez, Juan Carlos Martin (2021) Adult-onset Still's disease possibly consequent to asymptomatic COVID-19. EJMCR, 13 (July 2021): 218-221. doi:10.24911/ejmcr/173-1613255228
Chicago Style
Paula Ibanez, Angel Manuel Iniesta, Angel Robles, Mariana Gutierrez, Francisco Bermudez, Juan Carlos Martin. "Adult-onset Still's disease possibly consequent to asymptomatic COVID-19." 13 (2021), 218-221. doi:10.24911/ejmcr/173-1613255228
MLA (The Modern Language Association) Style
Paula Ibanez, Angel Manuel Iniesta, Angel Robles, Mariana Gutierrez, Francisco Bermudez, Juan Carlos Martin. "Adult-onset Still's disease possibly consequent to asymptomatic COVID-19." 13.July 2021 (2021), 218-221. Print. doi:10.24911/ejmcr/173-1613255228
APA (American Psychological Association) Style
Paula Ibanez, Angel Manuel Iniesta, Angel Robles, Mariana Gutierrez, Francisco Bermudez, Juan Carlos Martin (2021) Adult-onset Still's disease possibly consequent to asymptomatic COVID-19. , 13 (July 2021), 218-221. doi:10.24911/ejmcr/173-1613255228