Case Report

Volume: 4 | Issue: 11 | Published: Nov 10, 2020 | Pages: 404 - 407 | DOI: 10.24911/ejmcr/173-1600517952

A rare endocrine manifestation of Down syndrome: central precocious puberty: three cases report

Authors: Ayla Guven , Ayse Nurcan Cebeci

Article Info

Authors

Ayla Guven

University of Health Science Medical Faculty, Zeynep Kamil Women and Children Hospital, Pediatric Endocrinology, Istanbul, Turkey

Ayse Nurcan Cebeci

Demiroglu Bilim University, Medical Faculty, Department of Pediatric Endocrinology, Istanbul, Turkey

Publication History

Received: September 19, 2020

Revised: October 21, 2020

Accepted: October 24, 2020

Published: November 10, 2020

Abstract

Background: Although peripheral precocious puberty has been reported due to untreated long-standing hypothyroidism in children with Down syndrome (DS), central precocious puberty (CPP) has been scarcely reported. The aim of this study is to describe our experience with this rare condition. Case presentation: Three patients (two males and one female) who were receiving treatment for hypothyroidism and admitted with signs of precocious puberty were recruited in the study. Clinical and laboratory findings were compatible with CPP in all three patients with DS. They were euthyroid during investigations for CPP. A male patient had periventricular millimetric focuses in the supratentorial region in cranial magnetic resonance imaging. The other male patient developed central adrenal insufficiency during fallow-up and hence hydrocortisone was added to the treatment. All patients were successfully treated with gonadotropinreleasing hormone analogs; no adverse effects have been observed. Conclusion: Our findings emphasize that CPP might be seen in rare cases with DS and hypothyroidism.

Keywords: Down syndrome, central precocious puberty, hypothyroidism, leuprolide acetate, case reports, green

Open access Creative Commons License

Pubmed Style

Ayla Guven, Ayse Nurcan Cebeci. A rare endocrine manifestation of Down syndrome: central precocious puberty: three cases report. EJMCR. 2020; 10 (November 2020): 404-407. doi:10.24911/ejmcr/173-1600517952

Web Style

Ayla Guven, Ayse Nurcan Cebeci. A rare endocrine manifestation of Down syndrome: central precocious puberty: three cases report. https://ejmcr.com/articles/1379 [Access: December 26, 2024]. doi:10.24911/ejmcr/173-1600517952

AMA (American Medical Association) Style

Ayla Guven, Ayse Nurcan Cebeci. A rare endocrine manifestation of Down syndrome: central precocious puberty: three cases report. EJMCR. 2020; 10 (November 2020): 404-407. doi:10.24911/ejmcr/173-1600517952

Vancouver/ICMJE Style

Ayla Guven, Ayse Nurcan Cebeci. A rare endocrine manifestation of Down syndrome: central precocious puberty: three cases report. EJMCR. (2020), [cited December 26, 2024]; 10 (November 2020): 404-407. doi:10.24911/ejmcr/173-1600517952

Harvard Style

Ayla Guven, Ayse Nurcan Cebeci (2020) A rare endocrine manifestation of Down syndrome: central precocious puberty: three cases report. EJMCR, 10 (November 2020): 404-407. doi:10.24911/ejmcr/173-1600517952

Chicago Style

Ayla Guven, Ayse Nurcan Cebeci. "A rare endocrine manifestation of Down syndrome: central precocious puberty: three cases report." 10 (2020), 404-407. doi:10.24911/ejmcr/173-1600517952

MLA (The Modern Language Association) Style

Ayla Guven, Ayse Nurcan Cebeci. "A rare endocrine manifestation of Down syndrome: central precocious puberty: three cases report." 10.November 2020 (2020), 404-407. Print. doi:10.24911/ejmcr/173-1600517952

APA (American Psychological Association) Style

Ayla Guven, Ayse Nurcan Cebeci (2020) A rare endocrine manifestation of Down syndrome: central precocious puberty: three cases report. , 10 (November 2020), 404-407. doi:10.24911/ejmcr/173-1600517952