Case Report
Volume: 4 | Issue: 11 | Published: Nov 01, 2020 | Pages: 390 - 394 | DOI: 10.24911/ejmcr/173-1591892294
Palliative splenic irradiation for symptomatic splenomegaly in chronic myelomonocytic leukemia - case report
Authors: Andre Pires , Isabel Rodrigues , Andre Laranja , Angelo Oliveira , Joana Goncalves
Article Info
Authors
Andre Pires
Department of Radiation Oncology, Instituto Portugues de Oncologia do Porto Francisco Gentil, Porto, Portugal
Isabel Rodrigues
Department of Radiation Oncology, Instituto Portugues de Oncologia do Porto Francisco Gentil, Porto, Portugal
Andre Laranja
Department of Radiation Oncology, Instituto Portugues de Oncologia do Porto Francisco Gentil, Porto, Portugal
Angelo Oliveira
Department of Radiation Oncology, Instituto Portugues de Oncologia do Porto Francisco Gentil, Porto, Portugal
Joana Goncalves
Department of Radiation Oncology, Instituto Portugues de Oncologia do Porto Francisco Gentil, Porto, Portugal
Publication History
Received: June 11, 2020
Accepted: September 14, 2020
Published: November 01, 2020
Abstract
Background: Chronic myelomonocytic leukemia (CMML) is a rare malignant disorder that presents with splenomegaly in about 30% of cases. Case presentation: A 71-year-old man complained of abdominal pain, left hypochondrium distension, and weight loss. After work-up, a diagnosis of CMML was conducted, and the patient started chemotherapy. After about 2 years, he experienced clinical worsening compatible with symptomatic splenomegaly, and was proposed for radiotherapy. The patient underwent palliative splenic irradiation (SI), initially with 0.25 Gy fractions, delivered every other day, but the treatment was suspended after four fractions due to thrombocytopenia; 4 weeks later, the treatment was resumed, but was suspended again after 4 × 0.25 Gy fractions due to hematological changes. The patient was kept in palliative care and died 6 weeks later. Conclusion: SI has emerged as an alternative, widely used for palliation symptomatic splenomegaly in patients with hematological malignancies. This is the first report of SI for symptomatic splenomegaly on a patient with CMML.
Keywords: Radiotherapy, splenomegaly, splenic irradiation, chronic myelomonocytic leukemia, case report, green
Pubmed Style
Andre Pires, Isabel Rodrigues, Andre Laranja, Angelo Oliveira, Joana Goncalves. Palliative splenic irradiation for symptomatic splenomegaly in chronic myelomonocytic leukemia - case report. EJMCR. 2020; 01 (November 2020): 390-394. doi:10.24911/ejmcr/173-1591892294
Web Style
Andre Pires, Isabel Rodrigues, Andre Laranja, Angelo Oliveira, Joana Goncalves. Palliative splenic irradiation for symptomatic splenomegaly in chronic myelomonocytic leukemia - case report. https://ejmcr.com/articles/1376 [Access: December 26, 2024]. doi:10.24911/ejmcr/173-1591892294
AMA (American Medical Association) Style
Andre Pires, Isabel Rodrigues, Andre Laranja, Angelo Oliveira, Joana Goncalves. Palliative splenic irradiation for symptomatic splenomegaly in chronic myelomonocytic leukemia - case report. EJMCR. 2020; 01 (November 2020): 390-394. doi:10.24911/ejmcr/173-1591892294
Vancouver/ICMJE Style
Andre Pires, Isabel Rodrigues, Andre Laranja, Angelo Oliveira, Joana Goncalves. Palliative splenic irradiation for symptomatic splenomegaly in chronic myelomonocytic leukemia - case report. EJMCR. (2020), [cited December 26, 2024]; 01 (November 2020): 390-394. doi:10.24911/ejmcr/173-1591892294
Harvard Style
Andre Pires, Isabel Rodrigues, Andre Laranja, Angelo Oliveira, Joana Goncalves (2020) Palliative splenic irradiation for symptomatic splenomegaly in chronic myelomonocytic leukemia - case report. EJMCR, 01 (November 2020): 390-394. doi:10.24911/ejmcr/173-1591892294
Chicago Style
Andre Pires, Isabel Rodrigues, Andre Laranja, Angelo Oliveira, Joana Goncalves. "Palliative splenic irradiation for symptomatic splenomegaly in chronic myelomonocytic leukemia - case report." 01 (2020), 390-394. doi:10.24911/ejmcr/173-1591892294
MLA (The Modern Language Association) Style
Andre Pires, Isabel Rodrigues, Andre Laranja, Angelo Oliveira, Joana Goncalves. "Palliative splenic irradiation for symptomatic splenomegaly in chronic myelomonocytic leukemia - case report." 01.November 2020 (2020), 390-394. Print. doi:10.24911/ejmcr/173-1591892294
APA (American Psychological Association) Style
Andre Pires, Isabel Rodrigues, Andre Laranja, Angelo Oliveira, Joana Goncalves (2020) Palliative splenic irradiation for symptomatic splenomegaly in chronic myelomonocytic leukemia - case report. , 01 (November 2020), 390-394. doi:10.24911/ejmcr/173-1591892294