Case Report
Volume: 4 | Issue: 6 | Published: Jan 01, 1970 | Pages: 213 - 217 | DOI: 10.24911/ejmcr/173-1586977338
Metanephric adenoma of the right kidney: a challenging diagnosis in a 49-year-old female
Authors: Nikolina Stavrinou , Aikaterini Roidou , Georgia Mitropoulou , Georgios Liadakis , Ioannis Provatas
Article Info
Authors
Nikolina Stavrinou
Department of Pathology, Athens General Hospital O Evangelismos, Athens, Greece
Aikaterini Roidou
Department of Pathology, Athens General Hospital O Evangelismos, Athens, Greece
Georgia Mitropoulou
Department of Pathology, Athens Childrens Hospital Agia Sofia, Athens, Greece
Georgios Liadakis
Department of Pathology, Athens General Hospital O Evangelismos, Athens, Greece
Ioannis Provatas
Department of Pathology, Athens General Hospital O Evangelismos, Athens, Greece
Publication History
Received: April 24, 2020
Accepted: May 18, 2020
Published: January 01, 1970
Abstract
Background: Metanephric adenoma of the kidney is a rare, usually solitary, and benign tumor of the kidney, predominately affecting female patients in the fifth or sixth decade of life. It is considered by some specialists to be the hyperdifferentiated benign end of the Wilms tumor spectrum. Case Presentation: The case was a 49-year-old woman with abdominal pain, a palpable mass in the right abdomen, and mild hematuria, without any other symptoms or laboratory findings. An ultrasonography and computed tomography revealed a tumor in the upper pole of the right kidney with a diameter of 5.3 cm. There was no infiltration of the neighboring structures and tissues. The differential diagnosis included papillary renal cell carcinoma, adult Wilms tumor, and metanephric adenoma. A partial nephrectomy was followed. The histological examination of the tumor revealed relatively small unvarying basophilic epithelial cells with scant cytoplasm, uniform nuclei, and some areas with nuclear grooves, delicate chromatin, and indistinct nucleoli in a loose non-cellular stroma and developed in a tightly packed alveolar, tubular, and rarely papillary pattern. The mitotic rate was extremely low. Tumor cells were positive for paired box gene 8, cluster differentiation 57, and Wilms tumor 1 and negative for racemase, cytokeratin 7, and EMA. The cell proliferation rate Ki-67 was extremely low, and there was diffuse, strong cytoplasmic positivity for BRAF V600E staining. Based on morphology and immunohistochemistry, the diagnosis of metanephric adenoma was made. Conclusion: Although metanephric adenomas may be difficult to diagnose clinically, the histological examination and the immunohistochemistry assay, including BRAF V600 staining, can make a safe diagnosis, avoiding the administration of incorrect treatment.
Keywords: Kidney, metanephric adenoma, benign, tumor, BRAF, green
Pubmed Style
Nikolina Stavrinou, Aikaterini Roidou, Georgia Mitropoulou, Georgios Liadakis, Ioannis Provatas. Metanephric adenoma of the right kidney: a challenging diagnosis in a 49-year-old female. EJMCR. 1970; 01 (January 1970): 213-217. doi:10.24911/ejmcr/173-1586977338
Web Style
Nikolina Stavrinou, Aikaterini Roidou, Georgia Mitropoulou, Georgios Liadakis, Ioannis Provatas. Metanephric adenoma of the right kidney: a challenging diagnosis in a 49-year-old female. https://ejmcr.com/articles/1421 [Access: December 04, 2024]. doi:10.24911/ejmcr/173-1586977338
AMA (American Medical Association) Style
Nikolina Stavrinou, Aikaterini Roidou, Georgia Mitropoulou, Georgios Liadakis, Ioannis Provatas. Metanephric adenoma of the right kidney: a challenging diagnosis in a 49-year-old female. EJMCR. 1970; 01 (January 1970): 213-217. doi:10.24911/ejmcr/173-1586977338
Vancouver/ICMJE Style
Nikolina Stavrinou, Aikaterini Roidou, Georgia Mitropoulou, Georgios Liadakis, Ioannis Provatas. Metanephric adenoma of the right kidney: a challenging diagnosis in a 49-year-old female. EJMCR. (1970), [cited December 04, 2024]; 01 (January 1970): 213-217. doi:10.24911/ejmcr/173-1586977338
Harvard Style
Nikolina Stavrinou, Aikaterini Roidou, Georgia Mitropoulou, Georgios Liadakis, Ioannis Provatas (1970) Metanephric adenoma of the right kidney: a challenging diagnosis in a 49-year-old female. EJMCR, 01 (January 1970): 213-217. doi:10.24911/ejmcr/173-1586977338
Chicago Style
Nikolina Stavrinou, Aikaterini Roidou, Georgia Mitropoulou, Georgios Liadakis, Ioannis Provatas. "Metanephric adenoma of the right kidney: a challenging diagnosis in a 49-year-old female." 01 (1970), 213-217. doi:10.24911/ejmcr/173-1586977338
MLA (The Modern Language Association) Style
Nikolina Stavrinou, Aikaterini Roidou, Georgia Mitropoulou, Georgios Liadakis, Ioannis Provatas. "Metanephric adenoma of the right kidney: a challenging diagnosis in a 49-year-old female." 01.January 1970 (1970), 213-217. Print. doi:10.24911/ejmcr/173-1586977338
APA (American Psychological Association) Style
Nikolina Stavrinou, Aikaterini Roidou, Georgia Mitropoulou, Georgios Liadakis, Ioannis Provatas (1970) Metanephric adenoma of the right kidney: a challenging diagnosis in a 49-year-old female. , 01 (January 1970), 213-217. doi:10.24911/ejmcr/173-1586977338