Case Report
Volume: 5 | Issue: 2 | Published: Feb 10, 2021 | Pages: 35 - 38 | DOI: 10.24911/ejmcr/173-1585124565
Rare subtype of hepatoblastoma in a young adult: difficulties in the histopathological differentiation from hepatocellular carcinoma
Authors: Chrysa Stamou , Georgia Mitropoulou , Kalliopi Pavlou , Helen Trihia , Ioannis Provatas
Article Info
Authors
Chrysa Stamou
Department of Pathology, Athens General Hospital O Evangelismos, Athens, Greece
Georgia Mitropoulou
Department of Pathology, Athens Childrens Hospital Agia Sofia, Athens, Greece
Kalliopi Pavlou
Department of Pathology, Athens General Hospital O Evangelismos, Athens, Greece
Helen Trihia
Department of Pathology, Cancer Hospital of Piraeus Metaxa, Piraeus, Greece
Ioannis Provatas
Department of Pathology, Athens General Hospital O Evangelismos, Athens, Greece
Publication History
Received: March 25, 2020
Revised: September 26, 2020
Accepted: October 21, 2020
Published: February 10, 2021
Abstract
Background: Hepatoblastoma is a primary malignant tumor of the liver usually occurring in children, whereas it is very rare in adults, affecting males slightly more. Case Presentation: We report a case of a 20-year old female patient with a palpable liver mass and significantly elevated alphafetoprotein (AFP), Serum Glutamic Oxaloacetic Transaminase, and Serum Glutamic-Pyruvic Transaminase values. The microscopic examination revealed a mixed cell population of small cells with an oval-shaped nucleus and scant relatively basophilic cytoplasm co-existing with larger cells with eosinophilic or clear cytoplasm, round nuclei, arranged in trabeculae of six or more cells separated by thin fibrous septa. The immunohistochemical assessment of the tumor cells revealed positivity for AFP, Glypican-3, Glutamate Synthetase, polyclonal Carcinoembryonic antigen, Cytokeratin (CK8/18), and Epithelial Specific Antigen/Ep-CAM, membranous and focally nuclear positivity for b-catenin, focal positivity for CK19 and vimentin and faintly focal positivity for Sallike protein-4 and Cluster Differentiation 99. The cell proliferation rate Ki-67 was high, at about 85% and concerning the prognostic markers, there was a positive expression of Cyclin D1 at approximately 80% of the tumor cells, whereas c-myc was negative. These findings drove us to the diagnosis of hepatoblastoma, macrotrabecular subtype. Conclusion: Although the age, medical history, clinical findings, and the laboratory investigations of the patient suggested hepatocellular carcinoma, on the histological examination the mixed blastematous morphology of the tumor combined with the results of the immunohistochemical assay, lead to the diagnosis of hepatoblastoma.
Keywords: Age, liver, hepatoblastoma, hepatocellular, green
Pubmed Style
Chrysa Stamou, Georgia Mitropoulou, Kalliopi Pavlou, Helen Trihia, Ioannis Provatas. Rare subtype of hepatoblastoma in a young adult: difficulties in the histopathological differentiation from hepatocellular carcinoma. EJMCR. 2021; 10 (February 2021): 35-38. doi:10.24911/ejmcr/173-1585124565
Web Style
Chrysa Stamou, Georgia Mitropoulou, Kalliopi Pavlou, Helen Trihia, Ioannis Provatas. Rare subtype of hepatoblastoma in a young adult: difficulties in the histopathological differentiation from hepatocellular carcinoma. https://ejmcr.com/articles/1329 [Access: December 26, 2024]. doi:10.24911/ejmcr/173-1585124565
AMA (American Medical Association) Style
Chrysa Stamou, Georgia Mitropoulou, Kalliopi Pavlou, Helen Trihia, Ioannis Provatas. Rare subtype of hepatoblastoma in a young adult: difficulties in the histopathological differentiation from hepatocellular carcinoma. EJMCR. 2021; 10 (February 2021): 35-38. doi:10.24911/ejmcr/173-1585124565
Vancouver/ICMJE Style
Chrysa Stamou, Georgia Mitropoulou, Kalliopi Pavlou, Helen Trihia, Ioannis Provatas. Rare subtype of hepatoblastoma in a young adult: difficulties in the histopathological differentiation from hepatocellular carcinoma. EJMCR. (2021), [cited December 26, 2024]; 10 (February 2021): 35-38. doi:10.24911/ejmcr/173-1585124565
Harvard Style
Chrysa Stamou, Georgia Mitropoulou, Kalliopi Pavlou, Helen Trihia, Ioannis Provatas (2021) Rare subtype of hepatoblastoma in a young adult: difficulties in the histopathological differentiation from hepatocellular carcinoma. EJMCR, 10 (February 2021): 35-38. doi:10.24911/ejmcr/173-1585124565
Chicago Style
Chrysa Stamou, Georgia Mitropoulou, Kalliopi Pavlou, Helen Trihia, Ioannis Provatas. "Rare subtype of hepatoblastoma in a young adult: difficulties in the histopathological differentiation from hepatocellular carcinoma." 10 (2021), 35-38. doi:10.24911/ejmcr/173-1585124565
MLA (The Modern Language Association) Style
Chrysa Stamou, Georgia Mitropoulou, Kalliopi Pavlou, Helen Trihia, Ioannis Provatas. "Rare subtype of hepatoblastoma in a young adult: difficulties in the histopathological differentiation from hepatocellular carcinoma." 10.February 2021 (2021), 35-38. Print. doi:10.24911/ejmcr/173-1585124565
APA (American Psychological Association) Style
Chrysa Stamou, Georgia Mitropoulou, Kalliopi Pavlou, Helen Trihia, Ioannis Provatas (2021) Rare subtype of hepatoblastoma in a young adult: difficulties in the histopathological differentiation from hepatocellular carcinoma. , 10 (February 2021), 35-38. doi:10.24911/ejmcr/173-1585124565