Case Report
Published: Nov 10, 2024 | DOI: 10.24911/ejmcr.173-1713245325
Severe Adenovirus Infections in Young Adults
Authors:
Ghadi Zebian
, Aurelie Guigon
, Christos Gkizas
, Sebastien Preau
, Arthur Durand
Article Info
Authors
Ghadi Zebian
CHU Lille, Service de Médecine Intensive - Réanimation, Lille, France.
Aurelie Guigon
CHU de Lille, Laboratoire de Virologie, Centre de Biologie Pathologie, Lille, France.
Christos Gkizas
CHU de Lille, Service de Radiologie, Lille, France.
Arthur Durand
CHU Lille, Service de Médecine Intensive - Réanimation, Lille, France.
Publication History
Received: April 16, 2024
Accepted: September 02, 2024
Published: November 10, 2024
Abstract
Background: Despite traditionally affecting individuals with compromised immune systems, severe human adenoviruses (HAdV) infections have been observed in young adults without immunodeficiency over recent decades.
Case Presentation: This case study documents two young patients infected with HAdV who experienced multi-organ failure, manifesting as respiratory distress, vasoplegia, myocardial injury, and kidney impairment. The resolution of organ failure correlated with the clearance of viral load, suggesting a potential prognostic indicator for infection outcomes. While the first case demonstrated a positive outcome with the resolution of viremia, regrettably, the second case succumbed to myocardial infarction followed by cardiac arrest. The use of cardiac monitoring may aid in the identification of significant myocardial complications associated with HAdV. Although various treatments, including the antiviral CIDOFOVIR, have been reported for immunocompromised individuals, it was not administered to our patients due to the favorable trajectory of the first case.
Tragically, the second case passed away before any potential antiviral intervention could be initiated.
Conclusion: HAdV infections can cause severe acute respiratory distress syndrome with multi-organ failure including severe cardiac complications in young non-immunocompromised adults.
Keywords: Case report, adenovirus, acute respiratory distress syndrome, intensive care unit, extracorporeal membrane oxygenation, pneumonia, viral pneumonia.
Pubmed Style
Ghadi Zebian, Aurelie Guigon, Christos Gkizas, Sebastien Preau, Arthur Durand. Severe Adenovirus Infections in Young Adults. EJMCR. 2024; 10 (November 2024): -. doi:10.24911/ejmcr.173-1713245325
Web Style
Ghadi Zebian, Aurelie Guigon, Christos Gkizas, Sebastien Preau, Arthur Durand. Severe Adenovirus Infections in Young Adults. https://ejmcr.com/articles/1557 [Access: December 22, 2024]. doi:10.24911/ejmcr.173-1713245325
AMA (American Medical Association) Style
Ghadi Zebian, Aurelie Guigon, Christos Gkizas, Sebastien Preau, Arthur Durand. Severe Adenovirus Infections in Young Adults. EJMCR. 2024; 10 (November 2024): -. doi:10.24911/ejmcr.173-1713245325
Vancouver/ICMJE Style
Ghadi Zebian, Aurelie Guigon, Christos Gkizas, Sebastien Preau, Arthur Durand. Severe Adenovirus Infections in Young Adults. EJMCR. (2024), [cited December 22, 2024]; 10 (November 2024): -. doi:10.24911/ejmcr.173-1713245325
Harvard Style
Ghadi Zebian, Aurelie Guigon, Christos Gkizas, Sebastien Preau, Arthur Durand (2024) Severe Adenovirus Infections in Young Adults. EJMCR, 10 (November 2024): -. doi:10.24911/ejmcr.173-1713245325
Chicago Style
Ghadi Zebian, Aurelie Guigon, Christos Gkizas, Sebastien Preau, Arthur Durand. "Severe Adenovirus Infections in Young Adults." 10 (2024), -. doi:10.24911/ejmcr.173-1713245325
MLA (The Modern Language Association) Style
Ghadi Zebian, Aurelie Guigon, Christos Gkizas, Sebastien Preau, Arthur Durand. "Severe Adenovirus Infections in Young Adults." 10.November 2024 (2024), -. Print. doi:10.24911/ejmcr.173-1713245325
APA (American Psychological Association) Style
Ghadi Zebian, Aurelie Guigon, Christos Gkizas, Sebastien Preau, Arthur Durand (2024) Severe Adenovirus Infections in Young Adults. , 10 (November 2024), -. doi:10.24911/ejmcr.173-1713245325