EJMCR |

Case Report

Volume: 8 | Issue: 1 | Published: Feb 20, 2024 | Pages: 18 - 21 | DOI: 10.24911/ejmcr.173-1696705928

Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon

Authors: Mussawair Hussain , Fayyaz Hussain , Unaiza Qamar , Safia Khan , Syed Asif Ali , Parvez Ahmed

Article Info

Authors

Mussawair Hussain

Hematology and BMT, Pakistan Kidney and Liver Institute and Research Center, Lahore, Pakistan

ORCID

Fayyaz Hussain

Hematology and BMT, Pakistan Kidney and Liver Institute and Research Center, Lahore, Pakistan

ORCID

Unaiza Qamar

Hematology and BMT, Pakistan Kidney and Liver Institute and Research Center, Lahore, Pakistan

Safia Khan

Hematology and BMT, Pakistan Kidney and Liver Institute and Research Center, Lahore, Pakistan

Syed Asif Ali

Saidu Teaching Hospital, Saidu Sharif Swat, Pakistan

Parvez Ahmed

Hematology and BMT, Pakistan Kidney and Liver Institute and Research Center, Lahore, Pakistan.

Publication History

Received: October 16, 2023

Revised: December 10, 2023

Accepted: February 01, 2024

Published: February 20, 2024

Abstract

ABSTRACT Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder characterized by a deficiency of GPI-anchored proteins on blood cells. It is associated with hemolysis, thromboembolic events, and bone marrow failure. Management includes complement inhibitors, anticoagulation, and stem cell transplantation. Spontaneous remission of PNH is rarely reported. Case Presentation: A 28-year-old male initially diagnosed with aplastic anemia developed PVT and was subsequently diagnosed with PNH. Due to the unavailability of complement inhibitors, anticoagulation therapy and supportive care were employed. Splenectomy with splenorenal shunt was performed for chronic thrombosis and associated complications. The patient achieved spontaneous remission with normalized blood counts and diminished PNH clone. Conclusion: Managing PNH in resource-limited settings presents challenges due to the unavailability of complement inhibitors. Spontaneous remission of PNH is rarely reported and needs further research. Multidisciplinary approach, accessibility to diagnostic tests and advanced treatments will enhance PNH management in resource limited settings.

Keywords: Aplastic anemia, Paroxysmal nocturnal hemoglobinuria, Portal vein thrombosis, splenectomy, Resource limited countries, green

Pubmed Style

Mussawair Hussain, Fayyaz Hussain, Unaiza Qamar, Safia Khan, Syed Asif Ali, Parvez Ahmed. Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon. EJMCR. 2024; 20 (February 2024): 18-21. doi:10.24911/ejmcr.173-1696705928

Web Style

Mussawair Hussain, Fayyaz Hussain, Unaiza Qamar, Safia Khan, Syed Asif Ali, Parvez Ahmed. Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon. https://ejmcr.com/articles/1266 [Access: December 25, 2024]. doi:10.24911/ejmcr.173-1696705928

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Mussawair Hussain, Fayyaz Hussain, Unaiza Qamar, Safia Khan, Syed Asif Ali, Parvez Ahmed. Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon. EJMCR. (2024), [cited December 25, 2024]; 20 (February 2024): 18-21. doi:10.24911/ejmcr.173-1696705928

Harvard Style

Mussawair Hussain, Fayyaz Hussain, Unaiza Qamar, Safia Khan, Syed Asif Ali, Parvez Ahmed (2024) Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon. EJMCR, 20 (February 2024): 18-21. doi:10.24911/ejmcr.173-1696705928

Chicago Style

Mussawair Hussain, Fayyaz Hussain, Unaiza Qamar, Safia Khan, Syed Asif Ali, Parvez Ahmed. "Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon." 20 (2024), 18-21. doi:10.24911/ejmcr.173-1696705928

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Mussawair Hussain, Fayyaz Hussain, Unaiza Qamar, Safia Khan, Syed Asif Ali, Parvez Ahmed (2024) Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon. , 20 (February 2024), 18-21. doi:10.24911/ejmcr.173-1696705928