EJMCR |

Case Report

Volume: 8 | Issue: 7 | Published: Jul 26, 2024 | Pages: 139 - 145 | DOI: 10.24911/ejmcr.173-1660235974

Weight loss, diarrhea, and polyneuropathy: could it be amyloidosis?

Authors: Luis Francisco Pineda Galindo , Zully Esmeralda Contreras Cortes , Andrea Avila Martinez , Maria del Rosario Mora Campos , Elsa Acosta Jimenez , Armando Perez Torres

Article Info

Authors

Luis Francisco Pineda Galindo

Department of Internal Medicine, Specialities Hospital National Medical Center La Raza IMSS, Mexico City

ORCID

Zully Esmeralda Contreras Cortes

Department of Internal Medicine, Specialities Hospital National Medical Center La Raza IMSS, Mexico City

Andrea Avila Martinez

Department of Internal Medicine, Specialities Hospital National Medical Center La Raza IMSS, Mexico City

Maria del Rosario Mora Campos

Department of Pathology, Specialties Hospital National Medical Center La Raza, IMSS, Mexico City, Mexico

Elsa Acosta Jimenez

Department of Pathology, Specialties Hospital National Medical Center La Raza, IMSS, Mexico City, Mexico

Armando Perez Torres

Department of Cell and Tissue Biology, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.

Publication History

Received: May 14, 2023

Revised: December 19, 2023

Accepted: December 19, 2023

Published: July 26, 2024

Abstract

Background: Amyloidosis is a multisystemic disease that may be hereditary, characterized by the deposit of amyloid in the extracellular space. Transthyretin-mediated (ATTRm) amyloidosis is the most common subtype of heredofamilial amyloidosis. The diagnosis is based on clinical suspicion and amyloid in tissues. Hepatic transplantation is the only treatment that prevents the synthesis of the amyloidogenic variants of transthyretin protein. Case Presentation: A 34-year-old male presented with weight loss, gastrointestinal symptomatology, and polyneuropathy associated with histopathologic deposits of amyloid in gastrointestinal and fat tissue as well as peripheral nerve. Conclusion: Hereditary familial amyloidosis (HFA) is a relatively rare disorder that leads to erroneous and delayed definitive diagnosis. Therefore, the diagnosis should be first based on a suspicion of the disease, and then proceed according to complete protocol.

Keywords: Amyloidosis, familial amyloidosis, polyneurophaty, diagnosis, biopsy, green

Pubmed Style

Luis Francisco Pineda Galindo, Zully Esmeralda Contreras Cortes, Andrea Avila Martinez, Maria del Rosario Mora Campos, Elsa Acosta Jimenez, Armando Perez Torres. Weight loss, diarrhea, and polyneuropathy: could it be amyloidosis?. EJMCR. 2024; 26 (July 2024): 139-145. doi:10.24911/ejmcr.173-1660235974

Web Style

Luis Francisco Pineda Galindo, Zully Esmeralda Contreras Cortes, Andrea Avila Martinez, Maria del Rosario Mora Campos, Elsa Acosta Jimenez, Armando Perez Torres. Weight loss, diarrhea, and polyneuropathy: could it be amyloidosis?. https://ejmcr.com/articles/1211 [Access: December 25, 2024]. doi:10.24911/ejmcr.173-1660235974

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Luis Francisco Pineda Galindo, Zully Esmeralda Contreras Cortes, Andrea Avila Martinez, Maria del Rosario Mora Campos, Elsa Acosta Jimenez, Armando Perez Torres. Weight loss, diarrhea, and polyneuropathy: could it be amyloidosis?. EJMCR. (2024), [cited December 25, 2024]; 26 (July 2024): 139-145. doi:10.24911/ejmcr.173-1660235974

Harvard Style

Luis Francisco Pineda Galindo, Zully Esmeralda Contreras Cortes, Andrea Avila Martinez, Maria del Rosario Mora Campos, Elsa Acosta Jimenez, Armando Perez Torres (2024) Weight loss, diarrhea, and polyneuropathy: could it be amyloidosis?. EJMCR, 26 (July 2024): 139-145. doi:10.24911/ejmcr.173-1660235974

Chicago Style

Luis Francisco Pineda Galindo, Zully Esmeralda Contreras Cortes, Andrea Avila Martinez, Maria del Rosario Mora Campos, Elsa Acosta Jimenez, Armando Perez Torres. "Weight loss, diarrhea, and polyneuropathy: could it be amyloidosis?." 26 (2024), 139-145. doi:10.24911/ejmcr.173-1660235974

MLA (The Modern Language Association) Style

Luis Francisco Pineda Galindo, Zully Esmeralda Contreras Cortes, Andrea Avila Martinez, Maria del Rosario Mora Campos, Elsa Acosta Jimenez, Armando Perez Torres. "Weight loss, diarrhea, and polyneuropathy: could it be amyloidosis?." 26.July 2024 (2024), 139-145. Print. doi:10.24911/ejmcr.173-1660235974

APA (American Psychological Association) Style

Luis Francisco Pineda Galindo, Zully Esmeralda Contreras Cortes, Andrea Avila Martinez, Maria del Rosario Mora Campos, Elsa Acosta Jimenez, Armando Perez Torres (2024) Weight loss, diarrhea, and polyneuropathy: could it be amyloidosis?. , 26 (July 2024), 139-145. doi:10.24911/ejmcr.173-1660235974