Background: This case report delves into the intricate interplay between medical and psychiatric domains through the detailed analysis of a 41-year-old female patient presenting with a myriad of symptoms, including decreased level of consciousness, urinary tract infection (UTI), and subsequent catatonia secondary to depression with psychotic features. Case presentation: The collaborative involvement of Internal Medicine, Neurology, Infectious Disease, and Adult Mental Health specialists underscores the necessity of a multidisciplinary approach. The temporal evolution of the patient’s condition, coupled with the sequential adjustments in treatment strategies, provides insights into the nuanced manifestations of overlapping medical and psychiatric conditions. Conclusion: This report aims to highlight the intricate diagnostic process, treatment challenges, and the collaborative efforts required for the successful management of this rare and multifaceted

Keywords: catatonia . diazepam . depression , psychiatry , multidesplinary