Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?
Authors: Luis Francisco Pineda Galindo, Zully Esmeralda Contreras Cortes, Andrea Avila Martinez, Maria del Rosario Mora Campos, Elsa Acosta Jimenez, Armando Perez Torres
BACKGROUND: Amyloidosis is a multisystemic disease that may be hereditary, characterized by the deposit of amyloid in the extracellular space [1,4]. Transthyretin-mediated (ATTRm) amyloidosis is the most common subtype of heredofamilial amyloidosis [5]. The diagnosis is based on clinical suspicion and demonstration. of amyloid in tissues [7]. Hepatic transplantation (HT) is the only treatment that prevents the synthesis of the amyloidogenic variants of TTR [16]. CASE PRESENTATION: A 34-year-old male who presented with weight loss, gastrointestinal symptomatology and polyneuropathy associated with histopathologic deposits of amyloid in gastrointestinal and fat tissue as well as peripheral nerve. CONCLUSION: Hereditary familial amyloidosis (HFA) is a relatively rare disorder which leads to erroneous and delayed definitive diagnosis. Therefore, the diagnosis should be first based on a suspicion of the disease, and then proceed with the according complete protocol.
Keywords: Amyloidosis, poluneuropathy, Trasnthyretin, Diagnosis, Biopsy.
Authors
Correspondence to:
Zully Esmeralda Contreras Cortés, Department of Internal Medicine, Specialties Hospital National Medical Center La Raza, IMSS, Mexico City zullyecc1009@gmail.com
Publication history:
Received 14 May 2023
Revised 19 Dec 2023
Accepted 10 Feb 2024
Published online 26 Jul 2024
Galindo LFP, Cortes ZEC, Martinez AA, Campos MdRM, Jimenez EA, Torres AP. Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?. EJMCR. Online First: 26 Jul, 2024. doi:
10.24911/ejmcr.173-1660235974
Galindo LFP, Cortes ZEC, Martinez AA, Campos MdRM, Jimenez EA, Torres AP. Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?. https://www.ejmcr.com/?mno=102679 [Access: July 27, 2024]. doi:
10.24911/ejmcr.173-1660235974
Galindo LFP, Cortes ZEC, Martinez AA, Campos MdRM, Jimenez EA, Torres AP. Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?. EJMCR. Online First: 26 Jul, 2024. doi:
10.24911/ejmcr.173-1660235974
Galindo LFP, Cortes ZEC, Martinez AA, Campos MdRM, Jimenez EA, Torres AP. Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?. EJMCR, [cited July 27, 2024]; Online First: 26 Jul, 2024. doi:
10.24911/ejmcr.173-1660235974
Galindo, L. F. P., Cortes, . Z. E. C., Martinez, . A. A., Campos, . M. d. R. M., Jimenez, . E. A. & Torres, . A. P. (2024) Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?. EJMCR, Online First: 26 Jul, 2024. doi:
10.24911/ejmcr.173-1660235974
Galindo, Luis Francisco Pineda, Zully Esmeralda Contreras Cortes, Andrea Avila Martinez, Maria del Rosario Mora Campos, Elsa Acosta Jimenez, and Armando Perez Torres. 2024. Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?. European Journal of Medical Case Reports, Online First: 26 Jul, 2024. doi:
10.24911/ejmcr.173-1660235974
Galindo, Luis Francisco Pineda, Zully Esmeralda Contreras Cortes, Andrea Avila Martinez, Maria del Rosario Mora Campos, Elsa Acosta Jimenez, and Armando Perez Torres. "Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?." European Journal of Medical Case Reports Online First: 26 Jul, 2024. doi:
10.24911/ejmcr.173-1660235974
Galindo, Luis Francisco Pineda, Zully Esmeralda Contreras Cortes, Andrea Avila Martinez, Maria del Rosario Mora Campos, Elsa Acosta Jimenez, and Armando Perez Torres. "Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?." European Journal of Medical Case Reports Online First: 26 Jul, 2024. Web. 27 Jul 2024 doi:
10.24911/ejmcr.173-1660235974
Galindo, L. F. P., Cortes, . Z. E. C., Martinez, . A. A., Campos, . M. d. R. M., Jimenez, . E. A. & Torres, . A. P. (2024) Weight loss, diarrhea and polyneuropathy: Could it be amyloidosis?. European Journal of Medical Case Reports, Online First: 26 Jul, 2024. doi:
10.24911/ejmcr.173-1660235974