Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report
Authors: Ioannis Provatas, Dimitrios Sabaziotis, Chrissa Stamou, Georgia Mitropoulou, Helen Trihia
Background: Extraosseous giant cell tumors involving visceral organs (pancreas, kidneys, bladder, etc.) and soft tissues present similar histological features to those occurring in the bones. Rarely, they may affect pancreas and their origin remains still controversial, with some authors supporting the epithelial and some others the mesenchymal origin. Case Presentation: We report the case of a pancreatic giant cell tumor with osteoclast-like cells, negative for epithelial markers. A 64-year-old man presented with a 2-month history of progressively worsening abdominal pain, radiating to the lumbar region. He reported no other symptoms. The abdominal clinical examination was unremarkable and there was no associated jaundice. Liver function tests remained within normal limits. His past medical history had nil of note. He underwent an outpatient abdominal computed tomography which revealed a large cystic lesion at the body of the pancreas measuring 10 × 7 × 6.5 cm. We proceeded with a limited excision of the pancreatic mass alone, avoiding major dissections that would unnecessarily increase morbidity and mortality and the postoperative course was good. The histological morphological and immunohistochemical assessment revealed two tumor cell types: osteoclast-like multinucleated giant cells and pleomorphic mononuclear cells, with bone formation and without important cellular and nuclear atypia. Conclusion: Pancreatic giant cell tumors with osteoclast-like giant cells are rare tumors of the pancreas with various clinical characteristics and controversial origin. En bloc resection has prevailed as the only beneficial treatment so far.
Keywords: Osteoclastic giant cell tumor of the pancreas, bone, osteoid
Authors
Correspondence to:
Ioannis Provatas, Locum Pathologist, Department of Pathology, Athens General Hospital "O Evangelismos", Athens, Greece iannispro@yahoo.co.uk
Publication history:
Received 22 Mar 2020
Revised 26 Sep 2020
Accepted 21 Oct 2020
Published online 22 Jan 2021
Published in print 30 Jan 2021
Provatas I, Sabaziotis D, Stamou C, Mitropoulou G, Trihia H. Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report. EJMCR. 2021; 5(1): 7-11. doi:
10.24911/ejmcr/173-1584863716
Provatas I, Sabaziotis D, Stamou C, Mitropoulou G, Trihia H. Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report. https://www.ejmcr.com/?mno=94410 [Access: May 13, 2024]. doi:
10.24911/ejmcr/173-1584863716
Provatas I, Sabaziotis D, Stamou C, Mitropoulou G, Trihia H. Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report. EJMCR. 2021; 5(1): 7-11. doi:
10.24911/ejmcr/173-1584863716
Provatas I, Sabaziotis D, Stamou C, Mitropoulou G, Trihia H. Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report. EJMCR. (2021), [cited May 13, 2024]; 5(1): 7-11. doi:
10.24911/ejmcr/173-1584863716
Provatas, I., Sabaziotis, . D., Stamou, . C., Mitropoulou, . G. & Trihia, . H. (2021) Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report. EJMCR, 5 (1), 7-11. doi:
10.24911/ejmcr/173-1584863716
Provatas, Ioannis, Dimitrios Sabaziotis, Chrissa Stamou, Georgia Mitropoulou, and Helen Trihia. 2021. Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report. European Journal of Medical Case Reports, 5 (1), 7-11. doi:
10.24911/ejmcr/173-1584863716
Provatas, Ioannis, Dimitrios Sabaziotis, Chrissa Stamou, Georgia Mitropoulou, and Helen Trihia. "Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report." European Journal of Medical Case Reports 5 (2021), 7-11. doi:
10.24911/ejmcr/173-1584863716
Provatas, Ioannis, Dimitrios Sabaziotis, Chrissa Stamou, Georgia Mitropoulou, and Helen Trihia. "Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report." European Journal of Medical Case Reports 5.1 (2021), 7-11. Print. doi:
10.24911/ejmcr/173-1584863716
Provatas, I., Sabaziotis, . D., Stamou, . C., Mitropoulou, . G. & Trihia, . H. (2021) Osteoclastic giant cell tumor of the pancreas with osteoid and bone formation: a case report. European Journal of Medical Case Reports, 5 (1), 7-11. doi:
10.24911/ejmcr/173-1584863716