Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon
Authors: Mussawair Hussain, Fayyaz Hussain, Unaiza Qamar, Safia Khan, Syed Asif Ali, Parvez Ahmed
ABSTRACT Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder characterized by a deficiency of GPI-anchored proteins on blood cells. It is associated with hemolysis, thromboembolic events, and bone marrow failure. Management includes complement inhibitors, anticoagulation, and stem cell transplantation. Spontaneous remission of PNH is rarely reported. Case Presentation: A 28-year-old male initially diagnosed with aplastic anemia developed PVT and was subsequently diagnosed with PNH. Due to the unavailability of complement inhibitors, anticoagulation therapy and supportive care were employed. Splenectomy with splenorenal shunt was performed for chronic thrombosis and associated complications. The patient achieved spontaneous remission with normalized blood counts and diminished PNH clone. Conclusion: Managing PNH in resource-limited settings presents challenges due to the unavailability of complement inhibitors. Spontaneous remission of PNH is rarely reported and needs further research. Multidisciplinary approach, accessibility to diagnostic tests and advanced treatments will enhance PNH management in resource limited settings.
Keywords: Aplastic anemia, Paroxysmal nocturnal hemoglobinuria, Portal vein thrombosis, splenectomy, Resource limited countries.
Authors
Correspondence to:
Mussawair Hussain, Hematology and BMT, Pakistan Kidney and Liver Institute and Research Center, Lahore, Pakistan drmussawir143@gmail.com
Publication history:
Received 16 Oct 2023
Revised 10 Dec 2023
Accepted 01 Feb 2024
Published online 20 Feb 2024
Published in print 19 Apr 2024
Hussain M, Hussain F, Qamar U, Khan S, Ali SA, Ahmed P. Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon. EJMCR. 2024; 8(1): 18-21. doi:
10.24911/ejmcr.173-1696705928
Hussain M, Hussain F, Qamar U, Khan S, Ali SA, Ahmed P. Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon. https://www.ejmcr.com/?mno=172358 [Access: May 17, 2024]. doi:
10.24911/ejmcr.173-1696705928
Hussain M, Hussain F, Qamar U, Khan S, Ali SA, Ahmed P. Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon. EJMCR. 2024; 8(1): 18-21. doi:
10.24911/ejmcr.173-1696705928
Hussain M, Hussain F, Qamar U, Khan S, Ali SA, Ahmed P. Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon. EJMCR. (2024), [cited May 17, 2024]; 8(1): 18-21. doi:
10.24911/ejmcr.173-1696705928
Hussain, M., Hussain, . F., Qamar, . U., Khan, . S., Ali, . S. A. & Ahmed, . P. (2024) Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon. EJMCR, 8 (1), 18-21. doi:
10.24911/ejmcr.173-1696705928
Hussain, Mussawair, Fayyaz Hussain, Unaiza Qamar, Safia Khan, Syed Asif Ali, and Parvez Ahmed. 2024. Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon. European Journal of Medical Case Reports, 8 (1), 18-21. doi:
10.24911/ejmcr.173-1696705928
Hussain, Mussawair, Fayyaz Hussain, Unaiza Qamar, Safia Khan, Syed Asif Ali, and Parvez Ahmed. "Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon." European Journal of Medical Case Reports 8 (2024), 18-21. doi:
10.24911/ejmcr.173-1696705928
Hussain, Mussawair, Fayyaz Hussain, Unaiza Qamar, Safia Khan, Syed Asif Ali, and Parvez Ahmed. "Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon." European Journal of Medical Case Reports 8.1 (2024), 18-21. Print. doi:
10.24911/ejmcr.173-1696705928
Hussain, M., Hussain, . F., Qamar, . U., Khan, . S., Ali, . S. A. & Ahmed, . P. (2024) Case report on "Spontaneous Remission in Paroxysmal Nocturnal Hemoglobinuria: A Rare Phenomenon. European Journal of Medical Case Reports, 8 (1), 18-21. doi:
10.24911/ejmcr.173-1696705928