Background: Multicystic peritoneal mesothelioma (MCPM) is an uncommon mesothelium-related neoplasm, representing 3%-5% of peritoneal mesotheliomas. The annual incidence rate is 2 per 1,000,000. Typically, it is discovered unintentionally and accompanied by subacute abdominal pain. Surgery is the initial treatment option and involves the removal of cysts entirely from the body. In our case we describe an uncommon clinical and radiological presentation of this rare clinical entity. Case Presentation: We present the case of a 48-year-old male who presented with severe abdominal pain. The computed tomography scan of the abdomen revealed a septate pluriconcameral oval formation, hyperdense, suprahydric density content. The patient underwent exploratory laparoscopy. Numerous cystic structures were discovered. A histopathological examination revealed the MCPM. The patient was discharged and pursued follow-up at a specialized center. Conclusion: MPCM is a neoplasm whose pathophysiology is yet unknown, due to the lack of longitudinal studies and its rarity. Further studies are necessary to improve the treatment and management of the patients.

Keywords: Case report; Multicystic Peritoneal Mesothelioma; Mesothelium Neoplasm; Intermediate Malignant Mesothelioma;