Background: Hematidrosis is an extremely rare condition in which the patient spontaneously starts sweating blood. Even though, this disease has existed for many centuries, due to its rarity and perceived religious connection made little progress in correctly evaluating its pathogenesis. Therefore, rather than getting the medical and emotional help these cases need, such cases often end up at the doorsteps of shamans, especially in developing countries. Case Presentation: Here, we describe a case of hematidrosis and its clinical presentation and treatment outcome. A 10-yearold female patient presented with complaints of episodic bleeding from the skin, predominantly from the trunk, oral cavity, and forehead. Blood investigations, including coagulation profile, platelet antigen study, etc. were completely normal. The patient was treated with propranolol and atropine transdermal patches, which showed improvement in her condition, and the bleeding eventually stopped. Conclusion: Standardized diagnostic and management criteria is needed to be developed for treating such patients better. Reporting such cases of hematidrosis and discussing them will eventually make disease management more uniform and bring more patient awareness to this frightening disease.

Keywords: Hematidrosis, hematohidrosis, blood in sweat.