Background: Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis, is a rare dermatological disorder characterized by fever and the sudden onset of a rash, which consists of multiple tender, red or bluish-red bumps or lesions. These lesions usually occur on the arms, legs, trunk, face, or neck. In some cases, additional systems of the body can become involved. Case Presentation: A 20-year-old male presented with chief complaints of fever, cough, and skin lesions. Laboratory investigations revealed an elevated erythrocyte sedimentation rate, C- reactive protein, neutrophils, and total leukocyte count. A skin biopsy was performed, and the patient was diagnosed with SS. Conclusion: The patient was treated with oral corticosteroids and other medications to alleviate his symptoms. He was discharged on a tapering dose of prednisolone, and follow-up after a month showed that he remained afebrile with no relapse of skin lesions.

Keywords: Sweet syndrome, inflammatory disorder, neutrophilic dermatosis, erythrocyte sedimentation rate, corticosteroids