Background: Cemento-ossifying fibroma (COF) is a relatively rare benign nonodontogenic fibro-osseous lesion, which arises from the mesenchymal blast cells of the periodontal ligament and involves immature bone trabeculae and cementoid formations. Case Presentation: A 45-year-old female patient presented with a unilocular lesion placed in the posterior region of the mandible. Uniform, rounded swelling was present in the buccal vestibule of the mandible. Clinical, radiologic, and histologic features of COF are discussed in this article. Conclusion: Although the COF etiology is not exact as yet, clinicians may keep in mind that tooth extraction history may accompany COF, as seen in this case.

Keywords: Cementoma, mandible, fibro-osseous, pathology, tumor, case report