EJMCR. 2020; 4(1): 25-28

Nipah virus infection with cerebellar dysfunction

Authors: Bhargavan Pallivalappil, Ummer Karadan, Jayakrishnan Chellenton, Robin George Manappallil.

ABSTRACT

Background: The Nipah virus (NiV), known to exist in various fruit bats, is associated with one of the deadliest infections affecting human beings. The virus has caused outbreaks in Malaysia, Singapore, Philippines, Bangladesh, and the West Bengal state of India. Pigs were the intermediate hosts during the Malaysian and Singaporean outbreaks and horses in Philippines; while the Indian and Bangladesh outbreaks saw a bat to human followed by human-to-human transmission. The infection is characterized by rapidly progressive encephalitis and acute respiratory distress syndrome, carrying a very high mortality rate. Case Presentation: We present the case of a middle-aged male who presented with fever, vomiting and loose stools, and throat pain. His initial blood investigations were normal. He later developed diplopia, cerebellar symptoms, and segmental sweating. His blood, urine, and throat swab tested positive for NiV. He was started on antivirals but succumbed to death. Conclusion: NiV infection, in humans, presents with a wide spectrum of clinical manifestations, ranging from asymptomatic infection to acute respiratory infection and fatal encephalitis. It is transmitted to humans from animals, such as bats or pigs, or contaminated foods. This was our first experience with NiV; and probably one of the first reported cases from our region. Our experience showed the occurrence of cerebellar symptoms in NiV infection.

Keywords:
Nipah virus, Paramyxoviridae, encephalitis, cerebellar dysfunction, acute respiratory distress syndrome, ribavirin


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Nipah virus infection with cerebellar dysfunction


Authors
Bhargavan Pallivalappil
Senior Consultant, Department of Internal Medicine, Baby Memorial Hospital, Calicut, Kerala, India
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Ummer Karadan
Senior Consultant, Department of Neurology, Baby Memorial Hospital, Calicut, Kerala, India
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Jayakrishnan Chellenton
Consultant, Department of Neurology, Baby Memorial Hospital, Calicut, Kerala, India
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Robin George Manappallil
Consultant, Department of Internal Medicine, Baby Memorial Hospital, Calicut, Kerala, India
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Correspondence to:
. Robin George Manappallil, Consultant, Department of Internal Medicine, Baby Memorial Hospital, Calicut, Kerala, India.; drrobingeorgempl@gmail.com

Publication history
Received 17 Jun 2019
Revised 13 Dec 2019
Accepted 01 Feb 2020
Published online 06 Feb 2020
Published in print 12 Feb 2020

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Pubmed Style

Pallivalappil B, Karadan U, Chellenton J, Manappallil RG. Nipah virus infection with cerebellar dysfunction. EJMCR. 2020; 4(1): 25-28. doi:10.24911/ejmcr/173-1560779512


Web Style

Pallivalappil B, Karadan U, Chellenton J, Manappallil RG. Nipah virus infection with cerebellar dysfunction. https://www.ejmcr.com/?mno=53125 [Access: February 22, 2020]. doi:10.24911/ejmcr/173-1560779512


AMA (American Medical Association) Style

Pallivalappil B, Karadan U, Chellenton J, Manappallil RG. Nipah virus infection with cerebellar dysfunction. EJMCR. 2020; 4(1): 25-28. doi:10.24911/ejmcr/173-1560779512


Vancouver/ICMJE Style

Pallivalappil B, Karadan U, Chellenton J, Manappallil RG. Nipah virus infection with cerebellar dysfunction. EJMCR. (2020), [cited February 22, 2020]; 4(1): 25-28. doi:10.24911/ejmcr/173-1560779512


Harvard Style

Pallivalappil, B., Karadan, . U., Chellenton, . J. & Manappallil, . R. G. (2020) Nipah virus infection with cerebellar dysfunction. EJMCR, 4 (1), 25-28. doi:10.24911/ejmcr/173-1560779512


Turabian Style

Pallivalappil, Bhargavan, Ummer Karadan, Jayakrishnan Chellenton, and Robin George Manappallil. 2020. Nipah virus infection with cerebellar dysfunction. European Journal of Medical Case Reports, 4 (1), 25-28. doi:10.24911/ejmcr/173-1560779512


Chicago Style

Pallivalappil, Bhargavan, Ummer Karadan, Jayakrishnan Chellenton, and Robin George Manappallil. "Nipah virus infection with cerebellar dysfunction." European Journal of Medical Case Reports 4 (2020), 25-28. doi:10.24911/ejmcr/173-1560779512


MLA (The Modern Language Association) Style

Pallivalappil, Bhargavan, Ummer Karadan, Jayakrishnan Chellenton, and Robin George Manappallil. "Nipah virus infection with cerebellar dysfunction." European Journal of Medical Case Reports 4.1 (2020), 25-28. Print. doi:10.24911/ejmcr/173-1560779512


APA (American Psychological Association) Style

Pallivalappil, B., Karadan, . U., Chellenton, . J. & Manappallil, . R. G. (2020) Nipah virus infection with cerebellar dysfunction. European Journal of Medical Case Reports, 4 (1), 25-28. doi:10.24911/ejmcr/173-1560779512


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